PMID- 28484225
OWN - NLM
STAT- MEDLINE
DCOM- 20181217
LR  - 20220321
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 May 8
TI  - Multimodality analysis of Hyper-reflective Foci and Hard Exudates in Patients 
      with Diabetic Retinopathy.
PG  - 1568
LID - 10.1038/s41598-017-01733-0 [doi]
LID - 1568
AB  - To investigate the correlations between hyper-reflective foci and hard exudates 
      in patients with non-proliferative diabetic retinopathy (NPDR) and proliferative 
      diabetic retinopathy (PDR) by spectral-domain optical coherence tomography (SD 
      OCT) images. Hyper-reflective foci in retinal SD OCT images were automatically 
      detected by the developed algorithm. Then, the cropped CFP images generated by 
      the semi-automatic registration method were automatically segmented for the hard 
      exudates and corrected by the experienced clinical ophthalmologist. Finally, a 
      set of 5 quantitative imaging features were automatically extracted from SD OCT 
      images, which were used for investigating the correlations of hyper-reflective 
      foci and hard exudates and predicting the severity of diabetic retinopathy. 
      Experimental results demonstrated the positive correlations in area and amount 
      between hard exudates and hyper-reflective foci at different stages of diabetic 
      retinopathy, with statistical significance (all p < 0.05). In addition, the area 
      and amount can be taken as potential discriminant indicators of the severity of 
      diabetic retinopathy.
FAU - Niu, Sijie
AU  - Niu S
AD  - School of Information Science and Engineering, University of Jinan, Jinan, 
      250022, China.
AD  - School of Computer Science and Engineering, Nanjing University of Science and 
      Technology, Nanjing, 210094, China.
FAU - Yu, Chenchen
AU  - Yu C
AD  - School of Computer Science and Engineering, Nanjing University of Science and 
      Technology, Nanjing, 210094, China.
FAU - Chen, Qiang
AU  - Chen Q
AD  - School of Computer Science and Engineering, Nanjing University of Science and 
      Technology, Nanjing, 210094, China. chen2qiang@njust.edu.cn.
FAU - Yuan, Songtao
AU  - Yuan S
AUID- ORCID: 0000-0001-9212-0664
AD  - Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical 
      University, Nanjing, 210094, China. yuansongtao@vip.sina.com.
FAU - Lin, Jiang
AU  - Lin J
AD  - Department of Endocrinology, Nanjing Medical University, Nanjing, 210094, China.
FAU - Fan, Wen
AU  - Fan W
AUID- ORCID: 0000-0001-5224-6895
AD  - Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical 
      University, Nanjing, 210094, China.
FAU - Liu, Qinghuai
AU  - Liu Q
AD  - Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical 
      University, Nanjing, 210094, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170508
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Diabetic Retinopathy/*pathology
MH  - Exudates and Transudates/*metabolism
MH  - Fundus Oculi
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - *Multimodal Imaging
MH  - Severity of Illness Index
MH  - Tomography, Optical Coherence
PMC - PMC5431476
COIS- The authors declare that they have no competing interests.
EDAT- 2017/05/10 06:00
MHDA- 2018/12/18 06:00
PMCR- 2017/05/08
CRDT- 2017/05/10 06:00
PHST- 2016/10/14 00:00 [received]
PHST- 2017/04/03 00:00 [accepted]
PHST- 2017/05/10 06:00 [entrez]
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2018/12/18 06:00 [medline]
PHST- 2017/05/08 00:00 [pmc-release]
AID - 10.1038/s41598-017-01733-0 [pii]
AID - 1733 [pii]
AID - 10.1038/s41598-017-01733-0 [doi]
PST - epublish
SO  - Sci Rep. 2017 May 8;7(1):1568. doi: 10.1038/s41598-017-01733-0.