PMID- 28484874
OWN - NLM
STAT- MEDLINE
DCOM- 20180911
LR  - 20181113
IS  - 1573-2983 (Electronic)
IS  - 0269-4042 (Linking)
VI  - 40
IP  - 3
DP  - 2018 Jun
TI  - Effects of arsenic toxicity beyond epigenetic modifications.
PG  - 955-965
LID - 10.1007/s10653-017-9967-9 [doi]
AB  - Worldwide chronic arsenic (As) poisoning by arsenic-contaminated groundwater is 
      one of the most threatening public health problems. Chronic inorganic As (inAs) 
      exposure has been associated with various forms of cancers and numerous other 
      pathological effects in humans, collectively known as arsenicosis. Over the past 
      decade, evidence indicated that As-induced epigenetic modifications have a role 
      in the adverse effects on human health. The main objective of this article is to 
      review the evidence on epigenetic modifications induced by arsenicals. The 
      epigenetic components play a crucial role in the regulation of gene expression, 
      at both transcriptional and posttranscriptional levels. We synthesized the large 
      body of existing research on arsenic exposure and epigenetic mechanisms of health 
      outcomes with an emphasis on recent publications. Changes in patterns of DNA 
      methylation, histone posttranslational modifications, and microRNAs have been 
      repeatedly observed after inAs exposure in laboratory studies and in studies of 
      human populations. Such alterations have the potential to disturb cellular 
      homeostasis, resulting in the modulation of key pathways in the As-induced 
      carcinogenesis. The present article reviews recent data on As-induced epigenetic 
      effects and concludes that it is time for heightened awareness of pathogenic 
      arsenic exposure, particularly for pregnant women and children, given the 
      potential for a long-lasting disturbed cellular homeostasis.
FAU - Bjorklund, Geir
AU  - Bjorklund G
AUID- ORCID: 0000-0003-2632-3935
AD  - Council for Nutritional and Environmental Medicine, Toften 24, 8610, Mo i Rana, 
      Norway. bjorklund@conem.org.
FAU - Aaseth, Jan
AU  - Aaseth J
AD  - Innlandet Hospital Trust and Inland Norway University of Applied Sciences, 
      Elverum, Norway.
FAU - Chirumbolo, Salvatore
AU  - Chirumbolo S
AD  - Department of Neurological and Movement Sciences, University of Verona, Verona, 
      Italy.
FAU - Urbina, Mauricio A
AU  - Urbina MA
AUID- ORCID: 0000-0001-8040-6147
AD  - Departamento de Zoologia, Facultad de Ciencias Naturales y Oceanograficas, 
      Universidad de Concepcion, Casilla 160-C, Concepcion, Chile.
FAU - Uddin, Riaz
AU  - Uddin R
AUID- ORCID: 0000-0001-8133-9732
AD  - Department of Pharmacy, Stamford University Bangladesh, Dhaka, Bangladesh.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170508
PL  - Netherlands
TA  - Environ Geochem Health
JT  - Environmental geochemistry and health
JID - 8903118
RN  - 0 (Water Pollutants, Chemical)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Arsenic/*toxicity
MH  - Arsenic Poisoning/*complications
MH  - Epigenesis, Genetic/*drug effects
MH  - Groundwater/chemistry
MH  - Humans
MH  - Water Pollutants, Chemical/*toxicity
OTO - NOTNLM
OT  - Arsenic
OT  - Arsenic health effects
OT  - Cancer
OT  - Chronic arsenic exposure
OT  - Drinking water
OT  - Human development
OT  - Skin lesions
EDAT- 2017/05/10 06:00
MHDA- 2018/09/12 06:00
CRDT- 2017/05/10 06:00
PHST- 2016/03/29 00:00 [received]
PHST- 2017/04/21 00:00 [accepted]
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2018/09/12 06:00 [medline]
PHST- 2017/05/10 06:00 [entrez]
AID - 10.1007/s10653-017-9967-9 [pii]
AID - 10.1007/s10653-017-9967-9 [doi]
PST - ppublish
SO  - Environ Geochem Health. 2018 Jun;40(3):955-965. doi: 10.1007/s10653-017-9967-9. 
      Epub 2017 May 8.