PMID- 28485270
OWN - NLM
STAT- MEDLINE
DCOM- 20180430
LR  - 20181113
IS  - 1052-2166 (Print)
IS  - 1555-3884 (Electronic)
IS  - 1052-2166 (Linking)
VI  - 17
IP  - 3
DP  - 2017 Jul 7
TI  - A Review of the Scaffold Protein Menin and its Role in Hepatobiliary Pathology.
PG  - 251-263
LID - 10.3727/105221617X695744 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN1) is a familial cancer syndrome with 
      neuroendocrine tumorigenesis of the parathyroid glands, pituitary gland, and 
      pancreatic islet cells. The MEN1 gene codes for the canonical tumor suppressor 
      protein, menin. Its protein structure has recently been crystallized, and it has 
      been investigated in a multitude of other tissues. In this review, we summarize 
      recent advancements in understanding the structure of the menin protein and its 
      function as a scaffold protein in histone modification and epigenetic gene 
      regulation. Furthermore, we explore its role in hepatobiliary autoimmune 
      diseases, cancers, and metabolic diseases. In particular, we discuss how menin 
      expression and function are regulated by extracellular signaling factors and 
      nuclear receptor activation in various hepatic cell types. How the many signaling 
      pathways and tissue types affect menin's diverse functions is not fully 
      understood. We show that small-molecule inhibitors affecting menin function can 
      shed light on menin's broad role in pathophysiology and elucidate distinct 
      menin-dependent processes. This review reveals menin's often dichotomous function 
      through analysis of its role in multiple disease processes and could potentially 
      lead to novel small-molecule therapies in the treatment of cholangiocarcinoma or 
      biliary autoimmune diseases.
FAU - Ehrlich, Laurent
AU  - Ehrlich L
FAU - Hall, Chad
AU  - Hall C
FAU - Meng, Fanyin
AU  - Meng F
FAU - Lairmore, Terry
AU  - Lairmore T
FAU - Alpini, Gianfranco
AU  - Alpini G
FAU - Glaser, Shannon
AU  - Glaser S
LA  - eng
GR  - R01 DK062975/DK/NIDDK NIH HHS/United States
GR  - R01 DK058411/DK/NIDDK NIH HHS/United States
GR  - R01 DK110035/DK/NIDDK NIH HHS/United States
GR  - R01 DK054811/DK/NIDDK NIH HHS/United States
GR  - I01 BX002192/BX/BLRD VA/United States
GR  - R01 DK107310/DK/NIDDK NIH HHS/United States
GR  - I01 BX000574/BX/BLRD VA/United States
GR  - I01 BX001724/BX/BLRD VA/United States
GR  - R01 DK076898/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20170428
PL  - United States
TA  - Gene Expr
JT  - Gene expression
JID - 9200651
RN  - 0 (Histones)
RN  - 0 (JunD protein, human)
RN  - 0 (MEN1 protein, human)
RN  - 0 (MIRN24 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 0 (Transcription Factors)
RN  - 0 (Transforming Growth Factor beta)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/metabolism
MH  - Cell Transformation, Neoplastic
MH  - Cholangiocarcinoma/metabolism
MH  - Epigenesis, Genetic
MH  - Fibrosis
MH  - Gene Expression Regulation, Neoplastic
MH  - Histone-Lysine N-Methyltransferase
MH  - Histones
MH  - Humans
MH  - Leukemia, Biphenotypic, Acute/metabolism
MH  - Liver/metabolism
MH  - Metabolic Diseases/metabolism
MH  - MicroRNAs/metabolism
MH  - Multiple Endocrine Neoplasia Type 1/genetics/*metabolism
MH  - Pancreas/metabolism
MH  - Proto-Oncogene Proteins/*metabolism
MH  - Proto-Oncogene Proteins c-jun/metabolism
MH  - Signal Transduction
MH  - Transcription Factors/metabolism
MH  - Transforming Growth Factor beta/metabolism
PMC - PMC5765438
MID - NIHMS931971
EDAT- 2017/05/10 06:00
MHDA- 2018/05/01 06:00
PMCR- 2017/04/28
CRDT- 2017/05/10 06:00
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2018/05/01 06:00 [medline]
PHST- 2017/05/10 06:00 [entrez]
PHST- 2017/04/28 00:00 [pmc-release]
AID - GE366 [pii]
AID - 10.3727/105221617X695744 [doi]
PST - ppublish
SO  - Gene Expr. 2017 Jul 7;17(3):251-263. doi: 10.3727/105221617X695744. Epub 2017 Apr 
      28.