PMID- 28485638
OWN - NLM
STAT- MEDLINE
DCOM- 20180426
LR  - 20201209
IS  - 1502-7708 (Electronic)
IS  - 0036-5521 (Linking)
VI  - 52
IP  - 8
DP  - 2017 Aug
TI  - Endoscopic findings of the gastric mucosa during long-term use of proton pump 
      inhibitor - a multicenter study.
PG  - 828-832
LID - 10.1080/00365521.2017.1322137 [doi]
AB  - BACKGROUND AND AIM: It is clinically important to diagnose drug-induced gastric 
      lesions correctly. Recently, the use of proton pump inhibitors (PPI) has 
      increased worldwide. The histological features induced by PPI have been reported; 
      however, few reports have described endoscopic findings induced by PPI. 
      Therefore, we aimed to clarify the characteristic endoscopic features in PPI 
      users and associated pathogenic factors. METHODS: We prospectively registered 
      1007 consecutive participants (70 PPI users and 937 nonusers) who underwent 
      endoscopic examination for cancer screening in three hospitals/clinics. Clinical 
      data and endoscopic findings were recorded in the registration forms. We compared 
      the endoscopic features between the two groups and evaluated contributing factors 
      via univariate and multivariate analyses. RESULTS: Multiple white elevated 
      lesions (MWEL) and cobblestone-like mucosa (CLM) were more commonly observed in 
      PPI users compared with nonusers (p < .01). Foveolar hyperplastic polyps were 
      also frequently observed in PPI users but were not statistically significantly 
      different (p = .06). MWEL and CLM were more frequently observed in older patients 
      than in younger patients. MWEL was more frequently observed in female patients 
      than in male patients; however, CLM was predominantly observed in male patients. 
      CONCLUSION: MWEL and CLM are characteristic endoscopic features in PPI users. A 
      gender-associated difference was noted in terms of the frequency of these 
      lesions.
FAU - Kiso, Mariko
AU  - Kiso M
AD  - a Department of Gastroenterology and Metabolism , Hiroshima University , 
      Hiroshima , Japan.
FAU - Ito, Masanori
AU  - Ito M
AD  - a Department of Gastroenterology and Metabolism , Hiroshima University , 
      Hiroshima , Japan.
FAU - Boda, Tomoyuki
AU  - Boda T
AD  - b Department of Endoscopy , Hiroshima University Hospital , Hiroshima , Japan.
FAU - Kotachi, Takahiro
AU  - Kotachi T
AD  - a Department of Gastroenterology and Metabolism , Hiroshima University , 
      Hiroshima , Japan.
FAU - Masuda, Kazuhiko
AU  - Masuda K
AD  - a Department of Gastroenterology and Metabolism , Hiroshima University , 
      Hiroshima , Japan.
FAU - Hata, Kosaku
AU  - Hata K
AD  - a Department of Gastroenterology and Metabolism , Hiroshima University , 
      Hiroshima , Japan.
FAU - Sasaki, Atsunori
AU  - Sasaki A
AD  - c Medix Hiroshima GI Center , Hiroshima , Japan.
FAU - Kawamura, Toru
AU  - Kawamura T
AD  - d Kawamura Hospital , Hiroshima , Japan.
FAU - Yoshihara, Masaharu
AU  - Yoshihara M
AD  - e Department of Health Service Center , Hiroshima University , Higashi-Hiroshima 
      , Japan.
FAU - Tanaka, Shinji
AU  - Tanaka S
AD  - b Department of Endoscopy , Hiroshima University Hospital , Hiroshima , Japan.
FAU - Chayama, Kazuaki
AU  - Chayama K
AD  - a Department of Gastroenterology and Metabolism , Hiroshima University , 
      Hiroshima , Japan.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20170509
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Early Detection of Cancer
MH  - Endoscopy, Gastrointestinal
MH  - Female
MH  - Gastric Mucosa/*drug effects/microbiology/*pathology
MH  - Gastritis, Atrophic/chemically induced/*epidemiology
MH  - Helicobacter Infections/*epidemiology/microbiology
MH  - Helicobacter pylori
MH  - Humans
MH  - Japan/epidemiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Polyps/pathology
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/*adverse effects/therapeutic use
MH  - Sex Factors
MH  - Stomach Neoplasms/diagnosis
OTO - NOTNLM
OT  - Multiple white elevated lesions
OT  - cobblestone-like mucosa
OT  - proton pump inhibitor
EDAT- 2017/05/10 06:00
MHDA- 2018/04/27 06:00
CRDT- 2017/05/10 06:00
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2018/04/27 06:00 [medline]
PHST- 2017/05/10 06:00 [entrez]
AID - 10.1080/00365521.2017.1322137 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 2017 Aug;52(8):828-832. doi: 
      10.1080/00365521.2017.1322137. Epub 2017 May 9.