PMID- 28485899
OWN - NLM
STAT- MEDLINE
DCOM- 20180515
LR  - 20180816
IS  - 1530-0277 (Electronic)
IS  - 0145-6008 (Linking)
VI  - 41
IP  - 7
DP  - 2017 Jul
TI  - Determinants of Blood Brain-Derived Neurotrophic Factor Blood Levels in Patients 
      with Alcohol Use Disorder.
PG  - 1280-1287
LID - 10.1111/acer.13414 [doi]
AB  - BACKGROUND: Blood brain-derived neurotrophic factor (BDNF) levels are influenced 
      by both addiction and mood disorders, as well as somatic conditions, gender, and 
      genetic polymorphisms, leading to widely varying results. Depressive symptoms and 
      episodes are frequently observed in patients with alcohol use disorder, and vary 
      widely over time, making it a challenge to determine which aspects are 
      specifically involved in variations of serum BDNF levels in this population. 
      METHODS: We assessed 227 patients with alcohol dependence involved in a 
      detoxification program, at baseline and after a follow-up of 6 months, for the 
      Alcohol Use Disorders Identification Test score, the length of alcohol 
      dependence, and the number of past detoxification programs. The Beck Depression 
      Inventory and information on current tobacco and alcohol use, suicidal ideation, 
      body mass index, age, gender, and psychotropic treatments were also collected. 
      Serum BDNF (ELISA) and 2 genetic polymorphisms of the BDNF gene (Val33Met and 
      rs962369) were analyzed. RESULTS: The presence of the Met allele, 2 markers of 
      the history of alcohol dependence (gamma glutamyl transferase and the number of 
      past treatments in detoxification programs), and the presence of a depressive 
      episode (but not depressive score) were significantly associated with the 2 blood 
      levels of BDNF at baseline and after 6 months. After controlling for baseline 
      BDNF levels, the presence of the Met allele and an ongoing depressive episode 
      were the only variables associated with changes in BNDF levels after 6 months. 
      CONCLUSIONS: Low serum BDNF levels are associated with characteristics related to 
      alcohol consumption and mood disorders, and variants of the BDNF gene in alcohol 
      use disorder patients. The factors that most strongly influenced changes in serum 
      BDNF levels following treatment in an alcohol detoxification program were 
      variants of the BDNF gene and ongoing depression.
CI  - Copyright (c) 2017 by the Research Society on Alcoholism.
FAU - Nubukpo, Philippe
AU  - Nubukpo P
AD  - Pole d'Addictologie, Centre Hospitalier Esquirol, Limoges, France.
AD  - Unite de Recherche et de Neurostimulation, Centre Hospitalier Esquirol, Limoges, 
      France.
FAU - Ramoz, Nicolas
AU  - Ramoz N
AD  - Inserm UMR894, Centre de Psychiatrie et Neurosciences, Paris, France.
FAU - Girard, Murielle
AU  - Girard M
AUID- ORCID: 0000-0003-1222-0329
AD  - Unite de Recherche et de Neurostimulation, Centre Hospitalier Esquirol, Limoges, 
      France.
FAU - Malauzat, Dominique
AU  - Malauzat D
AD  - Unite de Recherche et de Neurostimulation, Centre Hospitalier Esquirol, Limoges, 
      France.
FAU - Gorwood, Philip
AU  - Gorwood P
AD  - Inserm UMR894, Centre de Psychiatrie et Neurosciences, Paris, France.
AD  - Clinique des Maladies Mentales et de l'Encephale (CMME), Hopital Sainte-Anne, 
      Universite Paris Descartes, Paris Cedex, France.
LA  - eng
PT  - Journal Article
DEP - 20170530
PL  - England
TA  - Alcohol Clin Exp Res
JT  - Alcoholism, clinical and experimental research
JID - 7707242
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Alcoholism/*blood/genetics/psychology/therapy
MH  - Brain-Derived Neurotrophic Factor/*blood/genetics
MH  - Cohort Studies
MH  - Depressive Disorder/*complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Alcohol
OT  - Brain-Derived Neurotrophic Factor
OT  - Depression
OT  - Withdrawal
EDAT- 2017/05/10 06:00
MHDA- 2018/05/16 06:00
CRDT- 2017/05/10 06:00
PHST- 2017/01/17 00:00 [received]
PHST- 2017/05/02 00:00 [accepted]
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2018/05/16 06:00 [medline]
PHST- 2017/05/10 06:00 [entrez]
AID - 10.1111/acer.13414 [doi]
PST - ppublish
SO  - Alcohol Clin Exp Res. 2017 Jul;41(7):1280-1287. doi: 10.1111/acer.13414. Epub 
      2017 May 30.