PMID- 28485986
OWN - NLM
STAT- MEDLINE
DCOM- 20180813
LR  - 20180813
IS  - 1939-022X (Electronic)
IS  - 1939-0211 (Linking)
VI  - 15
IP  - 1
DP  - 2018 Jan 2
TI  - Lotus Root Extract Stimulates BDNF Gene Expression Through Potential Mechanism 
      Depending on HO-1 Activity in C6 Glioma Cells.
PG  - 11-23
LID - 10.1080/19390211.2017.1310782 [doi]
AB  - Polyphenolic compounds have been suggested to be involved in the preservation of 
      neural function via the production of neurotrophic factors in the brain. The 
      nonedible joint part of lotus root (a rhizome of Nelumbo nucifera) has been 
      reported to contain large amounts of polyphenolic compounds and, therefore, is 
      expected to improve neural function by stimulating the production of 
      brain-derived neurotrophic factor (BDNF) in glial cells. The effect of the 
      aqueous extract prepared from the joint part of lotus root on BDNF gene 
      expression was examined in C6 glioma cells as an in vitro model. This extract was 
      shown to increase BDNF messenger ribonucleic acid (mRNA) levels to the elevation 
      of HO-1 mRNA levels in the glioma cells, but failed to cause the elevation of 
      BDNF mRNA levels in the cells pretreated with a HO-1 antisense 
      oligodeoxynucleotide (ODN) or an HO-1 enzyme inhibitor zinc protoporphyrin 
      (ZnPP). These findings strongly suggest that the aqueous extract prepared from 
      the nonedible joint part of lotus root might be able to stimulate BDNF gene 
      expression by enhancing HO-1 activity in the glioma cells, proposing the 
      possibility that the joint part of lotus root might potentially improve neural 
      function through the stimulation of BDNF production in glial cells.
FAU - Nishibori, Naoyoshi
AU  - Nishibori N
AD  - a Department of Food Science and Nutrition , Shikoku Junior College , Ohjin, 
      Tokushima , Japan.
AD  - b Life Science Research Group , Shikoku University School of Health Sciences , 
      Ohjin , Tokushima , Japan.
FAU - Kishibuchi, Reina
AU  - Kishibuchi R
AD  - b Life Science Research Group , Shikoku University School of Health Sciences , 
      Ohjin , Tokushima , Japan.
FAU - Her, Song
AU  - Her S
AD  - c Division of Bio-Imaging, Chuncheon Center , Korea Basic Science Institute , 
      Chuncheon , Republic of Korea.
FAU - Lee, Mi-Sook
AU  - Lee MS
AD  - c Division of Bio-Imaging, Chuncheon Center , Korea Basic Science Institute , 
      Chuncheon , Republic of Korea.
FAU - Morita, Kyoji
AU  - Morita K
AD  - b Life Science Research Group , Shikoku University School of Health Sciences , 
      Ohjin , Tokushima , Japan.
LA  - eng
PT  - Journal Article
DEP - 20170509
PL  - England
TA  - J Diet Suppl
JT  - Journal of dietary supplements
JID - 101249830
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Plant Extracts)
RN  - 0 (RNA, Messenger)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*drug effects
MH  - Cell Line, Tumor
MH  - Glioma/genetics
MH  - Heme Oxygenase-1/*metabolism
MH  - Nelumbo/*chemistry
MH  - Neuroglia/metabolism
MH  - Plant Extracts/*pharmacology
MH  - RNA, Messenger/drug effects
MH  - Rats
MH  - Rhizome/*chemistry
OTO - NOTNLM
OT  - BDNF gene transcription
OT  - HO-1 activity
OT  - lotus root
OT  - neurotrophic factor
OT  - nonedible joint part
EDAT- 2017/05/10 06:00
MHDA- 2018/08/14 06:00
CRDT- 2017/05/10 06:00
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2018/08/14 06:00 [medline]
PHST- 2017/05/10 06:00 [entrez]
AID - 10.1080/19390211.2017.1310782 [doi]
PST - ppublish
SO  - J Diet Suppl. 2018 Jan 2;15(1):11-23. doi: 10.1080/19390211.2017.1310782. Epub 
      2017 May 9.