PMID- 28486837
OWN - NLM
STAT- MEDLINE
DCOM- 20181127
LR  - 20200701
IS  - 1747-0927 (Electronic)
IS  - 1747-0919 (Print)
IS  - 1747-0919 (Linking)
VI  - 13
IP  - 3
DP  - 2018 Jun
TI  - Distinct effects of reminding mortality and physical pain on the default-mode 
      activity and activity underlying self-reflection.
PG  - 372-383
LID - 10.1080/17470919.2017.1329165 [doi]
AB  - Behavioral research suggests that reminding both mortality and negative affect 
      influences self-related thoughts. Using functional magnetic resonance imaging 
      (MRI), we tested the hypothesis that reminders of mortality and physical pain 
      decrease brain activity underlying self-related thoughts. Three groups of adults 
      underwent priming procedures during which they answered questions pertaining to 
      mortality, physical pain, or leisure time, respectively. Before and after 
      priming, participants performed personality trait judgments on oneself or a 
      celebrity, identified the font of words, or passively viewed a fixation. The 
      default-mode activity and neural activity underlying self-reflection were 
      identified by contrasting viewing a fixation vs. font judgment and trait 
      judgments on oneself vs. a celebrity, respectively. The analyses of the 
      pre-priming functional MRI (fMRI) data identified the default-mode activity in 
      the posterior cingulate cortex (PCC), ventral medial prefrontal cortex (MPFC), 
      and parahippocampal gyrus, and the activity underlying instructed self-reflection 
      in both the ventral and dorsal regions of the MPFC. The analyses of the 
      post-priming fMRI data revealed that, relative to leisure time priming, reminding 
      mortality significantly reduced the default-mode PCC activity, and reminding 
      physical pain significantly decreased the dorsal MPFC activity during instructed 
      self-reflection. Our findings suggest distinct neural underpinnings of the effect 
      of reminding morality and aversive emotion on default-mode and instructed 
      self-reflection.
FAU - Shi, Zhenhao
AU  - Shi Z
AD  - a School of Psychological and Cognitive Sciences, PKU-IDG/McGovern Institute for 
      Brain Research, Beijing Key Laboratory of Behavior and Mental Health , Peking 
      University , Beijing , China.
AD  - b Center for Studies of Addiction, Department of Psychiatry , University of 
      Pennsylvania Perelman School of Medicine , Philadelphia , PA , USA.
FAU - Han, Shihui
AU  - Han S
AD  - a School of Psychological and Cognitive Sciences, PKU-IDG/McGovern Institute for 
      Brain Research, Beijing Key Laboratory of Behavior and Mental Health , Peking 
      University , Beijing , China.
LA  - eng
GR  - F32 DA005589/DA/NIDA NIH HHS/United States
GR  - T32 DA028874/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170515
PL  - England
TA  - Soc Neurosci
JT  - Social neuroscience
JID - 101279009
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Brain/*diagnostic imaging/pathology
MH  - Brain Mapping
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Judgment/*physiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Mortality
MH  - Oxygen/blood
MH  - Pain/*diagnostic imaging
MH  - *Self Concept
MH  - Young Adult
PMC - PMC5685934
MID - NIHMS910966
OTO - NOTNLM
OT  - Self-reflection
OT  - fMRI
OT  - medial prefrontal cortex
OT  - mortality salience
OT  - posterior cingulate cortex
COIS- Disclosure statement The authors declare no competing financial interests.
EDAT- 2017/05/11 06:00
MHDA- 2018/11/28 06:00
PMCR- 2019/06/01
CRDT- 2017/05/11 06:00
PHST- 2017/05/11 06:00 [pubmed]
PHST- 2018/11/28 06:00 [medline]
PHST- 2017/05/11 06:00 [entrez]
PHST- 2019/06/01 00:00 [pmc-release]
AID - 10.1080/17470919.2017.1329165 [doi]
PST - ppublish
SO  - Soc Neurosci. 2018 Jun;13(3):372-383. doi: 10.1080/17470919.2017.1329165. Epub 
      2017 May 15.