PMID- 28486936
OWN - NLM
STAT- MEDLINE
DCOM- 20180122
LR  - 20240216
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 17
IP  - 1
DP  - 2017 May 10
TI  - Effects of inaccuracies in arterial path length measurement on differences in MRI 
      and tonometry measured pulse wave velocity.
PG  - 118
LID - 10.1186/s12872-017-0546-x [doi]
LID - 118
AB  - BACKGROUND: Carotid-femoral pulse wave velocity (cf-PWV) and aortic PWV measured 
      using MRI (MRI-PWV) show good correlation, but with a significant and consistent 
      bias across studies. The aim of the current study was to evaluate whether the 
      differences between cf.-PWV and MRI-PWV can be accounted for by inaccuracies of 
      currently used distance measurements. METHODS: One hundred fourteen study 
      participants were recruited into one of 4 groups: Type 2 diabetes melltus (T2DM) 
      with cardiovascular disease (CVD) (n = 23), T2DM without CVD (n = 41), CVD 
      without T2DM (n = 25) and a control group (n = 25). All participants underwent 
      cf.-PWV, cardiac MRI and whole body MR angiography(WB-MRA). 90 study participants 
      also underwent aortic PWV using MRI. cf.-PWV(EXT) was performed using a 
      SphygmoCor device (Atcor Medical, West Ryde, Australia). The true intra-arterial 
      pathlength was measured using the WB-MRA and then used to recalculate the 
      cf.-PWV(EXT) to give a cf.-PWV(MRA). RESULTS: Distance measurements were 
      significantly lower on WB-MRA than on external tape measure (mean 
      diff = -85.4 +/- 54.0 mm,p < 0.001). MRI-PWV was significantly lower than 
      cf.-PWV(EXT) (MRI-PWV = 8.1 +/- 2.9 vs. 
      cf.-PWV(EXT) = 10.9 +/- 2.7 ms(-1),p < 0.001). When cf.-PWV was recalculated using 
      the inter-arterial distance from WB-MRA, this difference was significantly 
      reduced but not lost (MRI-PWV = 8.1 +/- 2.9 ms(-1) vs. cf.-PWV(MRA) 
      9.1 +/- 2.1 ms(-1), mean diff = -0.96 +/- 2.52 ms(-1),p = 0.001). Recalculation of 
      the PWV increased correlation with age and pulse pressure. CONCLUSION: 
      Differences in cf.-PWV and MRI PWV can be predominantly but not entirely 
      explained by inaccuracies introduced by the use of simple surface measurements to 
      represent the convoluted arterial path between the carotid and femoral arteries.
FAU - Weir-McCall, Jonathan R
AU  - Weir-McCall JR
AUID- ORCID: 0000-0001-5842-842X
AD  - Division of Molecular and Clinical Medicine, Medical Research Institute, 
      University of Dundee, Dundee, DD1 9SY, UK.
FAU - Khan, Faisel
AU  - Khan F
AD  - Division of Molecular and Clinical Medicine, Medical Research Institute, 
      University of Dundee, Dundee, DD1 9SY, UK. f.khan@dundee.ac.uk.
FAU - Cassidy, Deirdre B
AU  - Cassidy DB
AD  - Division of Molecular and Clinical Medicine, Medical Research Institute, 
      University of Dundee, Dundee, DD1 9SY, UK.
FAU - Thakur, Arsh
AU  - Thakur A
AD  - Division of Molecular and Clinical Medicine, Medical Research Institute, 
      University of Dundee, Dundee, DD1 9SY, UK.
FAU - Summersgill, Jennifer
AU  - Summersgill J
AD  - Division of Molecular and Clinical Medicine, Medical Research Institute, 
      University of Dundee, Dundee, DD1 9SY, UK.
FAU - Matthew, Shona Z
AU  - Matthew SZ
AD  - Division of Molecular and Clinical Medicine, Medical Research Institute, 
      University of Dundee, Dundee, DD1 9SY, UK.
FAU - Adams, Fiona
AU  - Adams F
AD  - Division of Molecular and Clinical Medicine, Medical Research Institute, 
      University of Dundee, Dundee, DD1 9SY, UK.
FAU - Dove, Fiona
AU  - Dove F
AD  - Division of Molecular and Clinical Medicine, Medical Research Institute, 
      University of Dundee, Dundee, DD1 9SY, UK.
FAU - Gandy, Stephen J
AU  - Gandy SJ
AD  - NHS Tayside Medical Physics, Ninewells Hospital, Dundee, Scotland, UK.
FAU - Colhoun, Helen M
AU  - Colhoun HM
AD  - Centre for Genomic and Experimental Medicine, The University of Edinburgh, 
      Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland, UK.
FAU - Belch, Jill Jf
AU  - Belch JJ
AD  - Division of Molecular and Clinical Medicine, Medical Research Institute, 
      University of Dundee, Dundee, DD1 9SY, UK.
FAU - Houston, J Graeme
AU  - Houston JG
AD  - Division of Molecular and Clinical Medicine, Medical Research Institute, 
      University of Dundee, Dundee, DD1 9SY, UK. j.g.houston@dundee.ac.uk.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - WT 085664/WT_/Wellcome Trust/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20170510
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
SB  - IM
MH  - Aged
MH  - Aorta/*diagnostic imaging/physiopathology
MH  - Cardiovascular Diseases/*diagnostic imaging/physiopathology
MH  - Carotid Arteries/*diagnostic imaging/physiopathology
MH  - Diabetes Mellitus, Type 2/*complications/diagnosis
MH  - Diabetic Angiopathies/*diagnostic imaging/etiology/physiopathology
MH  - Female
MH  - Femoral Artery/*diagnostic imaging/physiopathology
MH  - Humans
MH  - *Magnetic Resonance Angiography
MH  - Male
MH  - *Manometry
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Pulse Wave Analysis/*methods
MH  - Regional Blood Flow
MH  - Reproducibility of Results
MH  - *Vascular Stiffness
MH  - Whole Body Imaging
PMC - PMC5424356
OTO - NOTNLM
OT  - Arteriosclerosis
OT  - Cardiovascular
OT  - Diabetes
OT  - MRI
OT  - PWV
EDAT- 2017/05/11 06:00
MHDA- 2018/01/23 06:00
PMCR- 2017/05/10
CRDT- 2017/05/11 06:00
PHST- 2017/02/14 00:00 [received]
PHST- 2017/04/28 00:00 [accepted]
PHST- 2017/05/11 06:00 [entrez]
PHST- 2017/05/11 06:00 [pubmed]
PHST- 2018/01/23 06:00 [medline]
PHST- 2017/05/10 00:00 [pmc-release]
AID - 10.1186/s12872-017-0546-x [pii]
AID - 546 [pii]
AID - 10.1186/s12872-017-0546-x [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2017 May 10;17(1):118. doi: 10.1186/s12872-017-0546-x.