PMID- 28487136
OWN - NLM
STAT- MEDLINE
DCOM- 20170912
LR  - 20220317
IS  - 1638-6183 (Electronic)
IS  - 0300-9084 (Linking)
VI  - 139
DP  - 2017 Aug
TI  - Role of MicroRNAs in Type 2 Diabetes and Associated Vascular Complications.
PG  - 9-19
LID - S0300-9084(17)30119-0 [pii]
LID - 10.1016/j.biochi.2017.05.007 [doi]
AB  - Type 2 diabetes mellitus (T2DM) has become a major health threat worldwide. 
      MicroRNAs (miRNAs) are a group of non-coding RNAs known to regulate various 
      biological processes including the pathogenesis of T2DM. Recent studies have 
      pointed out that specific miRNAs play a critical role in controlling beta cell 
      activities and the development of diabetic vascular complications. Their 
      association with the disease pathogenesis and omnipresence in body fluids have 
      made them important players for prognosis, diagnosis and management of T2DM. 
      Owing to the limitations of classical biomarkers of diabetes such as fasting 
      plasma glucose, glycosylated haemoglobin (HbA(1c)) lack in predicting the risk of 
      development of diabetes complications in a susceptible population. The miRNAs can 
      act as ideal biomarkers for diabetes associated complications. Identification of 
      specific miRNA signatures to detect diabetes and ideally to find out the risk of 
      development of diabetes-associated complications in susceptible population is the 
      essential requirement of the present clinical strategies for controlling diabetes 
      worldwide. In this article, we summarize the potential miRNAs and miRNA 
      signatures involved in the beta cell activities and diabetes associated 
      macrovascular and microvascular complications.
CI  - Copyright (c) 2017 Elsevier B.V. and Societe Francaise de Biochimie et Biologie 
      Moleculaire (SFBBM). All rights reserved.
FAU - Banerjee, Joyita
AU  - Banerjee J
AD  - Symbiosis School of Biological Sciences, Symbiosis International University, 
      Lavale, Pune, 412115, India.
FAU - Nema, Vijay
AU  - Nema V
AD  - National AIDS Research Institute, Bhosari, Pune, 411026, India.
FAU - Dhas, Yogita
AU  - Dhas Y
AD  - Symbiosis School of Biological Sciences, Symbiosis International University, 
      Lavale, Pune, 412115, India.
FAU - Mishra, Neetu
AU  - Mishra N
AD  - Symbiosis School of Biological Sciences, Symbiosis International University, 
      Lavale, Pune, 412115, India. Electronic address: nitumishra2007@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170506
PL  - France
TA  - Biochimie
JT  - Biochimie
JID - 1264604
RN  - 0 (Biomarkers)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Biomarkers/*blood
MH  - Cardiovascular Diseases/blood/*diagnosis/etiology
MH  - Diabetes Complications/blood/*diagnosis/etiology
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Humans
MH  - MicroRNAs/*blood/*genetics
OTO - NOTNLM
OT  - Macrovascular complications
OT  - Microvascular complications
OT  - Type 2 diabetes mellitus
OT  - microRNAs
OT  - beta cell activities
EDAT- 2017/05/11 06:00
MHDA- 2017/09/13 06:00
CRDT- 2017/05/11 06:00
PHST- 2016/12/14 00:00 [received]
PHST- 2017/05/05 00:00 [accepted]
PHST- 2017/05/11 06:00 [pubmed]
PHST- 2017/09/13 06:00 [medline]
PHST- 2017/05/11 06:00 [entrez]
AID - S0300-9084(17)30119-0 [pii]
AID - 10.1016/j.biochi.2017.05.007 [doi]
PST - ppublish
SO  - Biochimie. 2017 Aug;139:9-19. doi: 10.1016/j.biochi.2017.05.007. Epub 2017 May 6.