PMID- 28487838
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2233-8276 (Print)
IS  - 2233-8268 (Electronic)
IS  - 2233-8276 (Linking)
VI  - 7
IP  - 2
DP  - 2017 Apr
TI  - Impact of high serum Immunoglobulin E levels on the risk of atherosclerosis in 
      humans.
PG  - 74-81
LID - 10.5415/apallergy.2017.7.2.74 [doi]
AB  - BACKGROUND: Epidemiological studies show that immunoglobulin E (IgE) levels were 
      higher in subjects with acute coronary events. However, it is unknown if the 
      increased IgE level is a marker of future coronary incidents and whether it may 
      be regarded as a risk factor of an ischemic heart disease. OBJECTIVE: Our aim was 
      to investigate the relationship between IgE levels and some atherosclerotic 
      markers in patients without known atherosclerotic disease. METHODS: Fifty 
      patients (mean age, 40.96 +/- 10.8 years) with high serum IgE levels due to various 
      conditions who did not display evidence of an atherosclerotic disease and 30 
      healthy control subjects (mean age, 47 +/- 8.27 years) were included in the study. 
      Atherosclerotic disease markers including adhesion molecules like vascular cell 
      adhesion molecule-1, intercellular adhesion molecule-1, proinflammatory cytokines 
      such as interleukin-6, endothelin-1, and systemic inflammatory markers such as 
      high sensitivity C-reactive protein were determined by enzyme-linked 
      immunosorbent assay (ELISA). Endothelial functions of the coronary arteries were 
      determined by coronary flow reserve (CFR) measurements and carotid intima media 
      thickness using transthoracic Doppler echocardiography. RESULTS: CFR was 
      significantly lower in the patient group when compared with the control group 
      (p<0.001; 95% confidence interval, -0.79 to-0.20) while carotid media thicknesses 
      were not different between 2 groups. There were no differences in ELISA test 
      results between the 2 groups. CONCLUSION: Our results showed that CFR as an early 
      marker of endothelial dysfunction was significantly lower in patients with high 
      IgE levels. This finding seems to support the role of IgE in the vascular 
      pathology of atherosclerosis.
FAU - Unal, Derya
AU  - Unal D
AD  - Division of Immunology and Allergic Diseases, Department of Internal Medicine, 
      Istanbul Faculty of Medicine, Istanbul University, Istanbul 34015, Turkey.
FAU - Gelincik, Asli
AU  - Gelincik A
AD  - Division of Immunology and Allergic Diseases, Department of Internal Medicine, 
      Istanbul Faculty of Medicine, Istanbul University, Istanbul 34015, Turkey.
FAU - Elitok, Ali
AU  - Elitok A
AD  - Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul 34015, Turkey.
FAU - Demir, Semra
AU  - Demir S
AD  - Division of Immunology and Allergic Diseases, Department of Internal Medicine, 
      Istanbul Faculty of Medicine, Istanbul University, Istanbul 34015, Turkey.
FAU - Olgac, Muge
AU  - Olgac M
AD  - Division of Immunology and Allergic Diseases, Department of Internal Medicine, 
      Istanbul Faculty of Medicine, Istanbul University, Istanbul 34015, Turkey.
FAU - Coskun, Raif
AU  - Coskun R
AD  - Division of Immunology and Allergic Diseases, Department of Internal Medicine, 
      Istanbul Faculty of Medicine, Istanbul University, Istanbul 34015, Turkey.
FAU - Kocaaga, Mehmet
AU  - Kocaaga M
AD  - Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul 34015, Turkey.
FAU - Colakoglu, Bahattin
AU  - Colakoglu B
AD  - Division of Immunology and Allergic Diseases, Department of Internal Medicine, 
      Istanbul Faculty of Medicine, Istanbul University, Istanbul 34015, Turkey.
FAU - Buyukozturk, Suna
AU  - Buyukozturk S
AD  - Division of Immunology and Allergic Diseases, Department of Internal Medicine, 
      Istanbul Faculty of Medicine, Istanbul University, Istanbul 34015, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20170407
PL  - Netherlands
TA  - Asia Pac Allergy
JT  - Asia Pacific allergy
JID - 101561954
PMC - PMC5410414
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Carotid Intima-media thickness
OT  - Coronary flow reserve
OT  - Immunglobulin E
EDAT- 2017/05/11 06:00
MHDA- 2017/05/11 06:01
PMCR- 2017/04/01
CRDT- 2017/05/11 06:00
PHST- 2016/11/07 00:00 [received]
PHST- 2017/04/06 00:00 [accepted]
PHST- 2017/05/11 06:00 [entrez]
PHST- 2017/05/11 06:00 [pubmed]
PHST- 2017/05/11 06:01 [medline]
PHST- 2017/04/01 00:00 [pmc-release]
AID - 10.5415/apallergy.2017.7.2.74 [doi]
PST - ppublish
SO  - Asia Pac Allergy. 2017 Apr;7(2):74-81. doi: 10.5415/apallergy.2017.7.2.74. Epub 
      2017 Apr 7.