PMID- 28488039
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20190603
IS  - 1573-4838 (Electronic)
IS  - 0957-4530 (Linking)
VI  - 28
IP  - 6
DP  - 2017 Jun
TI  - Development of antimicrobial coating by layer-by-layer [corrected] dip coating of 
      chlorhexidine-loaded micelles.
PG  - 90
LID - 10.1007/s10856-017-5899-2 [doi]
AB  - Layer-by-layer (LbL) dip coating, accompanying with the use of micelle structure, 
      allows hydrophobic molecules to be coated on medical devices' surface via 
      hydrogen bonding interaction. In addition, micelle structure also allows control 
      release of encapsulated compound. In this research, we investigated methods to 
      coat and maximize the amount of chlorhexidine (CHX) on silicone surface through 
      LbL dip coating method utilizing hydrogen bonding interaction between PEG on 
      micelle corona and PAA. The number of coated cycles was varied in the process and 
      90 coating cycles provided the maximum amount of CHX loaded onto the surface. In 
      addition, pre-coating the surface with PAA enhanced the amount of coated CHX by 
      20%. Scanning electron microscope (SEM) and Fourier Transform Infrared 
      Spectroscopy (FTIR) were used to validate and characterize the coating. For 
      control release aspect, the coated film tended to disrupt at physiological 
      condition; hence chemical crosslinking was performed to minimize the disruption 
      and maximize the release time. Chemical crosslinking at pH 2.5 and 4.5 were 
      performed in the process. It was found that chemical crosslinking could help 
      extend the release period up to 18 days. This was significantly longer when 
      compared to the non-crosslinking silicone tube that could only prolong the 
      release for 5 days. In addition, chemical crosslinking at pH 2.5 gave higher and 
      better initial burst release, release period and antimicrobial properties than 
      that of pH 4.5 or the normal used pH for chemical crosslinking process.
FAU - Tambunlertchai, Supreeda
AU  - Tambunlertchai S
AD  - Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, 
      Nakorn Pathom, Thailand.
FAU - Srisang, Siriwan
AU  - Srisang S
AD  - Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, 
      Nakorn Pathom, Thailand.
FAU - Nasongkla, Norased
AU  - Nasongkla N
AD  - Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, 
      Nakorn Pathom, Thailand. norased.nas@mahidol.ac.th.
LA  - eng
PT  - Journal Article
DEP - 20170509
PL  - United States
TA  - J Mater Sci Mater Med
JT  - Journal of materials science. Materials in medicine
JID - 9013087
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Drug Carriers)
RN  - 0 (Micelles)
RN  - R4KO0DY52L (Chlorhexidine)
SB  - IM
EIN - J Mater Sci Mater Med. 2017 Aug;28(8):118. PMID: 28685230
MH  - Absorbable Implants
MH  - Anti-Bacterial Agents/*chemistry/pharmacology
MH  - Biocompatible Materials
MH  - Catheters
MH  - Chlorhexidine/*chemistry/pharmacology
MH  - *Drug Carriers
MH  - Materials Testing
MH  - *Micelles
MH  - Microbial Sensitivity Tests
MH  - Staphylococcus aureus/drug effects
EDAT- 2017/05/11 06:00
MHDA- 2018/03/10 06:00
CRDT- 2017/05/11 06:00
PHST- 2017/01/02 00:00 [received]
PHST- 2017/04/26 00:00 [accepted]
PHST- 2017/05/11 06:00 [entrez]
PHST- 2017/05/11 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
AID - 10.1007/s10856-017-5899-2 [pii]
AID - 10.1007/s10856-017-5899-2 [doi]
PST - ppublish
SO  - J Mater Sci Mater Med. 2017 Jun;28(6):90. doi: 10.1007/s10856-017-5899-2. Epub 
      2017 May 9.