PMID- 28488691
OWN - NLM
STAT- MEDLINE
DCOM- 20180801
LR  - 20221207
IS  - 1476-5640 (Electronic)
IS  - 0954-3007 (Linking)
VI  - 71
IP  - 12
DP  - 2017 Dec
TI  - Interaction effect of PGC-1alpha rs10517030 variants and energy intake in the risk of 
      type 2 diabetes in middle-aged adults.
PG  - 1442-1448
LID - 10.1038/ejcn.2017.68 [doi]
AB  - BACKGROUND/OBJECTIVES: PGC-1alpha is an important regulatory factor for energy and 
      glucose metabolism. Therefore, we investigated whether the PGC-1alpha genotype 
      (rs10517030 and rs10212638) affects the incidence of type 2 diabetes mellitus 
      (T2DM) and sought to explain the interactions between their variants and nutrient 
      intake on the development of T2DM. SUBJECTS/METHODS: Subjects aged 40-65 years of 
      both genders were from the Ansung/Ansan cohorts (8842 adults) in Korea. 
      Associations of PGC-1alpha variants rs10517030 and rs10212638 with T2DM were analyzed 
      in a dominant genetic model, and were tested for interactions of genotypes and 
      nutrients with T2DM risk. It was adjusted for covariates related to glucose 
      metabolism. RESULTS: Three variants, rs10517030, rs10517032 and rs10212638, were 
      positively associated with T2DM prevalence. Single-nucleotide polymorphisms, 
      rs10517030 and rs10517032, had strong association (r(2)=0.963). In the glucose 
      tolerance tests, odds ratios (ORs) for serum glucose levels at 120 min were 
      higher for subjects who were in the minor-allele group (minor allele homozygotes 
      and heterozygotes) than for the major-allele group (major allele homozygotes) for 
      rs10517030 variants. Serum insulin levels at 60 min had a lower ORs in the 
      minor-allele group of rs10517030 variants. The interaction between energy intake 
      and PGC-1alpha rs10517030 variants also affected T2DM risk. PGC-1alpha minor alleles were 
      linked to T2DM prevalence and homeostasis model assessment estimate of insulin 
      resistance (HOMA-IR) only in the low-energy groups, and HOMA-B was significantly 
      negatively associated with the minor-allele group of PGC-1alpha rs10517030 variants, 
      only in the low-energy-intake groups. CONCLUSIONS: These data suggest that 
      Koreans with the minor alleles of PGC-1alpha rs10517030, rs10517032 and rs10212638 
      are at greater risk of T2DM, and that a low-energy diet is more protective 
      against the development of T2DM in subjects with the major alleles of rs10517030 
      and rs10517032.
FAU - Park, S
AU  - Park S
AD  - Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo 
      University, Asan, South Korea.
FAU - Kim, B C
AU  - Kim BC
AD  - Department of Nanobiotronics, Hoseo University, Asan, South Korea.
FAU - Kang, S
AU  - Kang S
AD  - Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo 
      University, Asan, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20170510
PL  - England
TA  - Eur J Clin Nutr
JT  - European journal of clinical nutrition
JID - 8804070
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (PPARGC1A protein, human)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asian People/genetics
MH  - Blood Glucose/metabolism
MH  - Body Composition
MH  - Body Mass Index
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology/*genetics
MH  - *Diet
MH  - Electric Impedance
MH  - *Energy Intake
MH  - Female
MH  - Genotyping Techniques
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Middle Aged
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Prevalence
MH  - Republic of Korea/epidemiology
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Triglycerides/blood
EDAT- 2017/05/11 06:00
MHDA- 2018/08/02 06:00
CRDT- 2017/05/11 06:00
PHST- 2016/11/11 00:00 [received]
PHST- 2017/01/29 00:00 [revised]
PHST- 2017/03/19 00:00 [accepted]
PHST- 2017/05/11 06:00 [pubmed]
PHST- 2018/08/02 06:00 [medline]
PHST- 2017/05/11 06:00 [entrez]
AID - ejcn201768 [pii]
AID - 10.1038/ejcn.2017.68 [doi]
PST - ppublish
SO  - Eur J Clin Nutr. 2017 Dec;71(12):1442-1448. doi: 10.1038/ejcn.2017.68. Epub 2017 
      May 10.