PMID- 28488755
OWN - NLM
STAT- MEDLINE
DCOM- 20180321
LR  - 20220408
IS  - 1526-4610 (Electronic)
IS  - 0017-8748 (Linking)
VI  - 57
IP  - 6
DP  - 2017 Jun
TI  - Frequency-Dependent Habituation Deficit of the Nociceptive Blink Reflex in Aura 
      With Migraine Headache. Can Migraine Aura Modulate Trigeminal Excitability?
PG  - 887-898
LID - 10.1111/head.13111 [doi]
AB  - OBJECTIVE: To study the influence of the migraine aura on the trigeminal 
      nociception, we investigated the habituation of the nociceptive blink reflex 
      (nBR) R2 responses in aura with migraine headache (AwMH) and comparatively in 
      migraine without aura (MWoA) and healthy subjects (HS). BACKGROUND: A clear 
      deficit of habituation in trigeminal nociceptive responses has been documented in 
      MWoA; however, similar data in MWA are lacking. METHODS: Seventeen AwMH, 29 MWoA, 
      and 30 HS were enrolled and a nonrandomized clinical neurophysiological study 
      examining nBR habituation by clinical diagnosis was devised. We delivered a 
      series of 26 electrical stimuli, at different stimulation frequencies (SF) (0.05, 
      0.1, 0.2, 0.3, 0.5, and 1 Hz), subsequently subdivided in five blocks of five 
      responses for each SF. The mean area values of the second to the fifth block 
      expressed as the percentage of the mean area value of the first block were taken 
      as an index of habituation for each SF. RESULTS: A significant lower mean 
      percentage decrease of the R2 area across all blocks was found at 1, 0.5, 0.3, 
      and 0.2 Hz SF in MWoA and at 0.3 and 0.2 Hz SF in AwMH, when compared to HS. In 
      the most representative fifth block of responses, we found in MWoA vs HS at 1 Hz, 
      57.0 +/- 27.8 vs 30.6 +/- 12.0; at 0.5 Hz, 54.8 +/- 26.1 vs 32.51 +/- 17.7; at 0.3 Hz, 
      44.7 +/- 21.6 vs 27.6 +/- 13.2; at 0.2 Hz, 61.3 +/- 29.5 vs 32.6 +/- 18.0, and in AwMH vs 
      HS at 0.3 Hz, 52.7 +/- 24.7 vs 27.6 +/- 13.2; at 0.2 Hz, 69.3 +/- 38.6 vs 32.6 +/- 18.0 
      as mean +/- SD of the R2 area percentage of the first block, respectively. 
      Interestingly, AwMH subjects did not show differences in mean percentage decrease 
      of the R2 area at 1 and 0.5 Hz SF when compared to HS. No differences between 
      groups were found at 0.1 and 0.05 Hz SF. CONCLUSIONS: We demonstrated in AwMH a 
      deficit of habituation of the nBR R2 responses after repeated stimulations, 
      although less pronounced than that observed in MWoA of comparable clinical 
      severity. We hypothesize that AwMH and MWoA share some pathogenetic aspects, and 
      also that migraine aura physiopathology may play a modulating role on the 
      excitability of the nociceptive trigeminal pathways.
CI  - (c) 2017 American Headache Society.
FAU - Perrotta, Armando
AU  - Perrotta A
AD  - IRCCS Neuromed, Pozzilli, IS, Italy.
FAU - Anastasio, Maria Grazia
AU  - Anastasio MG
AD  - IRCCS Neuromed, Pozzilli, IS, Italy.
AD  - Department of Neurology and Psychiatry, "Sapienza" University of Rome, Rome, 
      Italy.
FAU - De Icco, Roberto
AU  - De Icco R
AD  - C. Mondino National Neurological Institute, Department of Brain and Behavioral 
      Sciences, University of Pavia, Italy.
FAU - Coppola, Gianluca
AU  - Coppola G
AD  - Foundation IRCCS, Research Unit of Neurophysiology of Vision and 
      Neurophthalmology, Rome, Italy Unit of Neurorehabilitation, Department of 
      Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, ICOT, 
      Latina, Italy.
FAU - Ambrosini, Anna
AU  - Ambrosini A
AD  - IRCCS Neuromed, Pozzilli, IS, Italy.
FAU - Serrao, Mariano
AU  - Serrao M
AD  - Foundation IRCCS, Research Unit of Neurophysiology of Vision and 
      Neurophthalmology, Rome, Italy Unit of Neurorehabilitation, Department of 
      Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, ICOT, 
      Latina, Italy.
FAU - Sandrini, Giorgio
AU  - Sandrini G
AD  - C. Mondino National Neurological Institute, Department of Brain and Behavioral 
      Sciences, University of Pavia, Italy.
FAU - Pierelli, Francesco
AU  - Pierelli F
AD  - IRCCS Neuromed, Pozzilli, IS, Italy.
AD  - Foundation IRCCS, Research Unit of Neurophysiology of Vision and 
      Neurophthalmology, Rome, Italy Unit of Neurorehabilitation, Department of 
      Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, ICOT, 
      Latina, Italy.
LA  - eng
PT  - Clinical Study
PT  - Comparative Study
PT  - Journal Article
DEP - 20170510
PL  - United States
TA  - Headache
JT  - Headache
JID - 2985091R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Area Under Curve
MH  - *Blinking/physiology
MH  - Electric Stimulation
MH  - Electromyography
MH  - Female
MH  - *Habituation, Psychophysiologic/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Migraine with Aura/*physiopathology
MH  - Migraine without Aura/*physiopathology
MH  - *Nociception/physiology
MH  - Oculomotor Muscles/physiopathology
MH  - *Reflex/physiology
MH  - Trigeminal Nuclei/physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - aura
OT  - habituation
OT  - migraine
OT  - nociceptive blink reflex
OT  - pain
EDAT- 2017/05/11 06:00
MHDA- 2018/03/22 06:00
CRDT- 2017/05/11 06:00
PHST- 2016/11/11 00:00 [received]
PHST- 2017/02/14 00:00 [revised]
PHST- 2017/02/27 00:00 [accepted]
PHST- 2017/05/11 06:00 [pubmed]
PHST- 2018/03/22 06:00 [medline]
PHST- 2017/05/11 06:00 [entrez]
AID - 10.1111/head.13111 [doi]
PST - ppublish
SO  - Headache. 2017 Jun;57(6):887-898. doi: 10.1111/head.13111. Epub 2017 May 10.