PMID- 28489021
OWN - NLM
STAT- MEDLINE
DCOM- 20180222
LR  - 20240326
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 18
IP  - 5
DP  - 2017 May 10
TI  - Calcium Dynamics Mediated by the Endoplasmic/Sarcoplasmic Reticulum and Related 
      Diseases.
LID - 10.3390/ijms18051024 [doi]
LID - 1024
AB  - The flow of intracellular calcium (Ca(2+)) is critical for the activation and 
      regulation of important biological events that are required in living organisms. 
      As the major Ca(2+) repositories inside the cell, the endoplasmic reticulum (ER) 
      and the sarcoplasmic reticulum (SR) of muscle cells are central in maintaining 
      and amplifying the intracellular Ca(2+) signal. The morphology of these 
      organelles, along with the distribution of key calcium-binding proteins (CaBPs), 
      regulatory proteins, pumps, and receptors fundamentally impact the local and 
      global differences in Ca(2+) release kinetics. In this review, we will discuss 
      the structural and morphological differences between the ER and SR and how they 
      influence localized Ca(2+) release, related diseases, and the need for targeted 
      genetically encoded calcium indicators (GECIs) to study these events.
FAU - Reddish, Florence N
AU  - Reddish FN
AD  - Department of Chemistry, Center for Diagnostics and Therapeutics (CDT), Georgia 
      State University, Atlanta, GA 30303, USA. freddish1@student.gsu.edu.
FAU - Miller, Cassandra L
AU  - Miller CL
AD  - Department of Chemistry, Center for Diagnostics and Therapeutics (CDT), Georgia 
      State University, Atlanta, GA 30303, USA. cmiller88@student.gsu.edu.
FAU - Gorkhali, Rakshya
AU  - Gorkhali R
AD  - Department of Chemistry, Center for Diagnostics and Therapeutics (CDT), Georgia 
      State University, Atlanta, GA 30303, USA. rgorkhali1@student.gsu.edu.
FAU - Yang, Jenny J
AU  - Yang JJ
AD  - Department of Chemistry, Center for Diagnostics and Therapeutics (CDT), Georgia 
      State University, Atlanta, GA 30303, USA. jenny@gsu.edu.
LA  - eng
GR  - R01 GM062999/GM/NIGMS NIH HHS/United States
GR  - R21 GM070555/GM/NIGMS NIH HHS/United States
GR  - R01 EB007268/EB/NIBIB NIH HHS/United States
GR  - R42 CA183376/CA/NCI NIH HHS/United States
GR  - R01 HL042220/HL/NHLBI NIH HHS/United States
GR  - R01 AG015820/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20170510
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Calcium Channels)
RN  - 0 (Calcium-Binding Proteins)
RN  - Brody myopathy
SB  - IM
MH  - Animals
MH  - Calcium Channels/genetics/metabolism
MH  - *Calcium Signaling
MH  - Calcium-Binding Proteins/genetics/metabolism
MH  - Humans
MH  - Malignant Hyperthermia/*genetics/metabolism
MH  - Myotonia Congenita/*genetics/metabolism
MH  - Sarcoplasmic Reticulum/genetics/*metabolism
MH  - Tachycardia/*genetics/metabolism
PMC - PMC5454937
OTO - NOTNLM
OT  - GECI
OT  - IP3R
OT  - JP45
OT  - RyR
OT  - SERCA pump
OT  - calcium signaling
OT  - calsequestrin
OT  - endoplasmic reticulum
OT  - sarcoplasmic reticulum
COIS- The authors declare no conflict of interest.
EDAT- 2017/05/11 06:00
MHDA- 2018/02/23 06:00
PMCR- 2017/05/01
CRDT- 2017/05/11 06:00
PHST- 2017/02/11 00:00 [received]
PHST- 2017/04/28 00:00 [revised]
PHST- 2017/05/01 00:00 [accepted]
PHST- 2017/05/11 06:00 [entrez]
PHST- 2017/05/11 06:00 [pubmed]
PHST- 2018/02/23 06:00 [medline]
PHST- 2017/05/01 00:00 [pmc-release]
AID - ijms18051024 [pii]
AID - ijms-18-01024 [pii]
AID - 10.3390/ijms18051024 [doi]
PST - epublish
SO  - Int J Mol Sci. 2017 May 10;18(5):1024. doi: 10.3390/ijms18051024.