PMID- 28490401
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20180309
IS  - 1945-8932 (Electronic)
IS  - 1945-8932 (Linking)
VI  - 31
IP  - 3
DP  - 2017 May 1
TI  - Immunopathologic characteristics of nasal polyps in adult Koreans: A 
      single-center study.
PG  - 168-173
LID - 10.2500/ajra.2017.31.4423 [doi]
AB  - BACKGROUND: Chronic rhinosinusitis with nasal polyps (NP) (CRSwNP) is classified 
      into eosinophilic and noneosinophilic types based on the level of tissue 
      eosinophilia. The immunopathologic features of Western and Asian CRSwNP differ. 
      OBJECTIVES: The aim of this study was to investigate the immunopathologic 
      characteristics of Korean patients with eosinophilic NP versus noneosinophilic NP 
      and those with atopic NP versus nonatopic NP. METHODS: Tissue samples were 
      collected from 81 patients with NP and 24 controls. The clinical characteristics 
      of all the patients were analyzed. Tissues were investigated for expression of 
      chemical mediators, including interleukin (IL) 5, IL-10, IL-17, interferon-gamma, and 
      tumor growth factor-beta1; transcription factors, including GATA binding protein 3 
      (GATA-3), forkhead box P3 (Foxp3), retinoic acid-related orphan receptor C 
      (RORC), and T-box transcription factor (T-bet), and extracellular matrix, 
      including collagen type I, fibronectin, tissue inhibitor of metalloproteinase 1, 
      and matrix metalloproteinase (MMP) 9. RESULTS: Although the clinical 
      characteristics differed between eosinophilic and noneosinophilic NPs, atopic 
      status did not affect the clinical findings of CRSwNP. Both T-helper 1 and 2 
      cytokines increased significantly in patients with eosinophilic NP, but atopic 
      status did not affect the expression of any of the chemical mediators. GATA-3 
      messenger RNA (mRNA) expression increased significantly in patients with 
      eosinophilic NP, and RORC mRNA expression increased significantly in patients 
      with noneosinophilic NP. T-bet, RORC, and Foxp3 mRNA expression increased 
      significantly in patients with nonatopic NP. Fibronectin and MMP-9 mRNA 
      expression increased significantly in patients with noneosinophilic NP, whereas 
      only MMP-9 mRNA increased significantly in patients with eosinophilic and those 
      with noneosinophilic NP. CONCLUSION: The immunopathologic characteristics 
      differed between eosinophilic NP and noneosinophilic NP and between atopic NP and 
      nonatopic NP. The different underlying pathogenic processes may influence the 
      development of Korean NP.
FAU - Shin, Seung-Heon
AU  - Shin SH
FAU - Kim, Yee-Hyuk
AU  - Kim YH
FAU - Ye, Mi-Kyung
AU  - Ye MK
FAU - Choi, Sung-Yong
AU  - Choi SY
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Rhinol Allergy
JT  - American journal of rhinology & allergy
JID - 101490775
RN  - 0 (Cytokines)
RN  - 0 (FOXP3 protein, human)
RN  - 0 (Fibronectins)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (GATA3 protein, human)
RN  - 0 (Nuclear Receptor Subfamily 1, Group F, Member 3)
RN  - 0 (RORC protein, human)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (T-box transcription factor TBX21)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adult
MH  - Cytokines/genetics/metabolism
MH  - Eosinophils/*immunology
MH  - Fibronectins/metabolism
MH  - Forkhead Transcription Factors/genetics/metabolism
MH  - GATA3 Transcription Factor/genetics/metabolism
MH  - Humans
MH  - Hypersensitivity, Immediate/complications/*immunology
MH  - Korea
MH  - Matrix Metalloproteinase 9/genetics/metabolism
MH  - Nasal Polyps/complications/*immunology
MH  - Nuclear Receptor Subfamily 1, Group F, Member 3/genetics/metabolism
MH  - T-Box Domain Proteins/genetics/metabolism
MH  - Th1 Cells/*immunology
MH  - Th2 Cells/*immunology
EDAT- 2017/05/12 06:00
MHDA- 2018/03/10 06:00
CRDT- 2017/05/12 06:00
PHST- 2017/05/12 06:00 [entrez]
PHST- 2017/05/12 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
AID - 10.2500/ajra.2017.31.4423 [doi]
PST - ppublish
SO  - Am J Rhinol Allergy. 2017 May 1;31(3):168-173. doi: 10.2500/ajra.2017.31.4423.