PMID- 28491445
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2055-1169 (Print)
IS  - 2055-1169 (Electronic)
IS  - 2055-1169 (Linking)
VI  - 2
IP  - 2
DP  - 2016 Jul-Dec
TI  - Primary adrenal lymphoma causing hypoaldosteronism in a cat.
PG  - 2055116916684409
LID - 10.1177/2055116916684409 [doi]
LID - 2055116916684409
AB  - CASE SUMMARY: A 10-year-old, 5.1 kg (11.2 lb), male castrated cat was presented 
      with signs of lethargy and decreased appetite at home after being previously 
      healthy. Serum biochemical analysis identified normokalemia (5.1 mmol/l; 
      reference interval [RI] 3.4-5.6 mmol/l) and severe hyponatremia (123 mmol/l; RI 
      145-158 mmol/l), with an Na/K ratio of 24 (RI 32-41). Baseline serum cortisol was 
      low to normal, but serum aldosterone was markedly decreased with a 
      pre-adrenocorticotropic hormone stimulation concentration of 13 pmol/l (RI 
      194-388 pmol/l) and post-adrenocorticotropic hormone stimulation concentration of 
      21 pmol/l (RI 277-721 pmol/l). Hematologic and biochemical analyses were 
      otherwise unremarkable. Abdominal ultrasound revealed bilaterally enlarged 
      adrenal glands with no other abnormalities noted; thoracic radiographs also did 
      not identify any signs of metastasis. Fine-needle aspiration was strongly 
      suggestive of lymphoma of the adrenal glands, and PCR for antigen receptor 
      rearrangement was positive for B-cell clonal expansion; based on these findings, 
      a diagnosis of primary adrenal B-cell lymphoma was made. Stable disease was 
      achieved for a short period of time following vincristine, cyclophosphamide, 
      prednisolone and fludrocortisone therapy, followed by progressive adrenal 
      enlargement and electrolyte derangements that responded to neither doxorubicin 
      nor adjustments in fludrocortisone dosage. Ultrasonographic metastasis was not 
      identified at any time, and other organ derangements were not noted on 
      hematologic or biochemical analyses. The cat was euthanized 55 days after initial 
      presentation. RELEVANCE AND NOVEL INFORMATION: This is the first report of 
      primary adrenal lymphoma in a cat, with presenting signs compatible with 
      hypoaldosteronism. Lymphoma should be a differential for cats presenting with 
      adrenal enlargement or clinical signs and biochemical changes consistent with 
      hypoaldosteronism or hypoadrenocorticism.
FAU - Romine, Jessica F
AU  - Romine JF
AD  - Department of Internal Medicine, BluePearl Veterinary Partners, Southfield, MI, 
      USA.
FAU - Kozicki, Angela R
AU  - Kozicki AR
AD  - Department of Oncology, BluePearl Veterinary Partners, Southfield, MI, USA.
FAU - Elie, Marc S
AU  - Elie MS
AD  - Department of Internal Medicine, BluePearl Veterinary Partners, Southfield, MI, 
      USA.
LA  - eng
PT  - Case Reports
DEP - 20161201
PL  - England
TA  - JFMS Open Rep
JT  - JFMS open reports
JID - 101672978
PMC - PMC5415298
COIS- Conflict of interest: The authors declared no potential conflicts of interest 
      with respect to the research, authorship, and/or publication of this article.
EDAT- 2017/05/12 06:00
MHDA- 2017/05/12 06:01
PMCR- 2016/12/01
CRDT- 2017/05/12 06:00
PHST- 2017/05/12 06:00 [entrez]
PHST- 2017/05/12 06:00 [pubmed]
PHST- 2017/05/12 06:01 [medline]
PHST- 2016/12/01 00:00 [pmc-release]
AID - 10.1177_2055116916684409 [pii]
AID - 10.1177/2055116916684409 [doi]
PST - epublish
SO  - JFMS Open Rep. 2016 Dec 1;2(2):2055116916684409. doi: 10.1177/2055116916684409. 
      eCollection 2016 Jul-Dec.