PMID- 28493333
OWN - NLM
STAT- MEDLINE
DCOM- 20180608
LR  - 20181029
IS  - 1097-4547 (Electronic)
IS  - 0360-4012 (Linking)
VI  - 95
IP  - 12
DP  - 2017 Dec
TI  - Treadmill exercise attenuates 3,4-methylenedioxymethamphetamine-induced memory 
      impairment through a decrease apoptosis in male rat hippocampus.
PG  - 2448-2455
LID - 10.1002/jnr.24078 [doi]
AB  - 3,4-methylenedioxymethamphetamine (MDMA) leads to apoptosis in the hippocampus 
      with consequent induction of learning and memory impairment. In this study, we 
      have investigated the effects of treadmill exercise on memory in relation to 
      apoptosis and oxidative stress in the hippocampi of MDMA-treated rats. Male 
      Wistar rats received multiple intraperitoneal (IP) injections of MDMA (10 mg/kg) 
      and exercised for one month on a treadmill (simultaneously or asynchronously with 
      MDMA). We assessed memory function with the Morris water maze (MWM) test. Lipid 
      peroxidation (LPO) and expression of caspase 3, Bax, and Bcl-2 were examined by 
      the thiobarbituric acid assay (TBA) and western blot, respectively. Our results 
      showed that asynchronous treadmill exercise could significantly improve 
      MDMA-induced memory impairment in the MWM test. Caspase 3 expression decreased in 
      the exercise group compared to the MDMA group. Although MDMA treatment caused an 
      increase in the Bax/Bcl-2 ratio, the treadmill exercise reduced this ratio. 
      Simultaneous exercise caused a reduction in lipid peroxidation in the 
      hippocampus. This data suggests that treadmill exercise can be a useful strategy 
      for treating memory impairment in persons with neurodegenerative disease and 
      stimulant drug users. (c) 2017 Wiley Periodicals, Inc.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Gharebaghi, Alireza
AU  - Gharebaghi A
AD  - Research Center for Behavioral Disorders and Substance Abuse, Hamadan University 
      of Medical Sciences, Hamadan, Iran.
FAU - Amiri, Iraj
AU  - Amiri I
AD  - Endometrium and Endometriosis Research Center, Hamadan University of Medical 
      Sciences, Hamadan, Iran.
FAU - Salehi, Iraj
AU  - Salehi I
AD  - Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, 
      Iran.
FAU - Shahidi, Siamak
AU  - Shahidi S
AD  - Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, 
      Iran.
FAU - Komaki, Alireza
AU  - Komaki A
AD  - Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, 
      Iran.
FAU - Mehdizadeh, Mehdi
AU  - Mehdizadeh M
AD  - Cellular and Molecular Research Center, Faculty of Advanced Technologies in 
      Medicine, Department of Anatomy, Iran University of Medical Sciences, Tehran, 
      Iran.
FAU - Moravej, Fahimeh Ghasemi
AU  - Moravej FG
AD  - Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, 
      Hamadan, Iran.
FAU - Asl, Sara Soleimani
AU  - Asl SS
AUID- ORCID: 0000-0003-1518-3308
AD  - Research Center for Behavioral Disorders and Substance Abuse, Hamadan University 
      of Medical Sciences, Hamadan, Iran.
AD  - Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, 
      Hamadan, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170511
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Serotonin Agents)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Hippocampus/*pathology
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/etiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Physical Conditioning, Animal/*physiology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin Agents/*toxicity
OTO - NOTNLM
OT  - MDMA
OT  - apoptosis
OT  - exercise
OT  - hippocampus
OT  - memory
EDAT- 2017/05/12 06:00
MHDA- 2018/06/09 06:00
CRDT- 2017/05/12 06:00
PHST- 2016/10/18 00:00 [received]
PHST- 2017/04/12 00:00 [revised]
PHST- 2017/04/12 00:00 [accepted]
PHST- 2017/05/12 06:00 [pubmed]
PHST- 2018/06/09 06:00 [medline]
PHST- 2017/05/12 06:00 [entrez]
AID - 10.1002/jnr.24078 [doi]
PST - ppublish
SO  - J Neurosci Res. 2017 Dec;95(12):2448-2455. doi: 10.1002/jnr.24078. Epub 2017 May 
      11.