PMID- 28493982 OWN - NLM STAT- MEDLINE DCOM- 20170911 LR - 20240327 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 12 IP - 5 DP - 2017 TI - Comparison of spectral-domain optical coherence tomography for intra-retinal layers thickness measurements between healthy and diabetic eyes among Chinese adults. PG - e0177515 LID - 10.1371/journal.pone.0177515 [doi] LID - e0177515 AB - PURPOSE: To compare intra-retinal layer thickness measurements between eyes with no or mild diabetic retinopathy (DR) and age-matched controls using Spectralis spectral-domain optical coherence tomography (SD-OCT). METHODS: Cross-sectional observational analysis study. High-resolution macular volume scans (30 degrees * 25 degrees ) were obtained for 133 type 2 diabetes mellitus (T2DM) patients with no DR, 42 T2DM patients with mild DR and 115 healthy controls. The mean thickness was measured in all 9 Early Treatment Diabetic Retinopathy Study (ETDRS) sectors for 8 separate layers, inner retinal layer (IRL), outer retinal layer (ORL) and total retina (TR), after automated segmentation. The ETDRS grid consisted of three concentric circles of 1-, 3-, and 6-mm diameter. The superior, inferior, temporal, and nasal sectors of the 3- and 6-mm circles were respectively designated as S3, I3, T3, and N3 and S6, I6, T6, and N6. Linear regression analyses were conducted to evaluate the associations between the intra-retinal layer thicknesses, age, diabetes duration, fasting blood glucose and HbA1c. RESULTS: The mean age and duration of T2DM were 61.1 and 13.7 years, respectively. Although no significant differences in the average TR and ORL volumes were observed among the groups, significant differences were found in the volume and sectorial thicknesses of the inner plexiform layer (IPL), outer plexiform layer (OPL) and IRL among the groups. In particular, the thicknesses of the IPL (S3, T3, S6, I6 and T6 sectors) and the IRL (S6 sector) were decreased in the no-DR group compared with the controls (P < 0.05). The thickness of the OPL (S3, N3, S6 and N6 sectors) was thinner in the no-DR group than in mild DR (P < 0.05). The average IPL thickness was significantly negatively correlated with age and the duration of diabetes. CONCLUSION: The assessment of the intra-retinal layer thickness showed a significant decrease in the IPL and IRL thicknesses in Chinese adults with T2DM, even in the absence of visible microvascular signs of DR. FAU - Li, Shu-Ting AU - Li ST AD - Department of Ophthalmology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China. FAU - Wang, Xiang-Ning AU - Wang XN AD - Department of Ophthalmology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China. FAU - Du, Xin-Hua AU - Du XH AD - Department of Ophthalmology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China. FAU - Wu, Qiang AU - Wu Q AD - Department of Ophthalmology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China. AD - Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China. LA - eng PT - Comparative Study PT - Journal Article DEP - 20170511 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - *Asian People MH - Demography MH - Diabetes Mellitus, Type 2/*pathology MH - Female MH - Humans MH - Linear Models MH - Male MH - Middle Aged MH - Retina/*pathology MH - Tomography, Optical Coherence/*methods PMC - PMC5426752 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2017/05/12 06:00 MHDA- 2017/09/12 06:00 PMCR- 2017/05/11 CRDT- 2017/05/12 06:00 PHST- 2017/02/27 00:00 [received] PHST- 2017/04/29 00:00 [accepted] PHST- 2017/05/12 06:00 [entrez] PHST- 2017/05/12 06:00 [pubmed] PHST- 2017/09/12 06:00 [medline] PHST- 2017/05/11 00:00 [pmc-release] AID - PONE-D-17-07487 [pii] AID - 10.1371/journal.pone.0177515 [doi] PST - epublish SO - PLoS One. 2017 May 11;12(5):e0177515. doi: 10.1371/journal.pone.0177515. eCollection 2017.