PMID- 28495046
OWN - NLM
STAT- MEDLINE
DCOM- 20180316
LR  - 20180316
IS  - 1873-2364 (Electronic)
IS  - 0960-8966 (Linking)
VI  - 27
IP  - 7
DP  - 2017 Jul
TI  - Transient neonatal myasthenia gravis due to a mother with ocular onset of 
      anti-muscle specific kinase myasthenia gravis.
PG  - 655-657
LID - S0960-8966(17)30063-9 [pii]
LID - 10.1016/j.nmd.2017.03.012 [doi]
AB  - We describe a 27-year-old pregnant female with new onset of conjugate gaze 
      deficit during the third trimester of pregnancy. Repetitive nerve stimulation 
      tests, neostigmine tests, and acetylcholine receptor antibody assays were all 
      negative. The patient delivered a normal healthy baby at a local clinic via 
      cesarean section. The baby became hypotonic and had respiratory failure several 
      minutes after birth. The result of acetylcholine receptor antibody was negative 
      in the neonate. The neonate became healthy spontaneously and was extubated after 
      21 days of ventilation care. Two months after delivery, the mother developed 
      ptosis and generalized symptoms and subsequent workup revealed she was muscle 
      specific kinase (MuSK) antibody positive. The neonate was presumed to have an 
      anti-MuSK-mediated transient neonatal myasthenia gravis. Although MuSK antibody 
      testing is rarely indicated in ocular myasthenia gravis, MuSK antibody testing is 
      necessary in pregnant women who are presumed ocular myasthenia gravis to warn 
      occurrence of transient neonatal myasthenia gravis.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Lee, Ju-Yeun
AU  - Lee JY
AD  - Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul, Republic of Korea.
FAU - Min, Ju-Hong
AU  - Min JH
AD  - Department of Neurology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Republic of Korea.
FAU - Han, Sueng-Han
AU  - Han SH
AD  - Institute of Vision Research, Department of Ophthalmology, Gangnam Severance 
      Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
FAU - Han, Jinu
AU  - Han J
AD  - Institute of Vision Research, Department of Ophthalmology, Gangnam Severance 
      Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. 
      Electronic address: jinuhan@yuhs.ac.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170404
PL  - England
TA  - Neuromuscul Disord
JT  - Neuromuscular disorders : NMD
JID - 9111470
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, Cholinergic)
RN  - EC 2.7.10.1 (MUSK protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Adult
MH  - Autoantibodies/blood/immunology
MH  - Blepharoptosis/*etiology
MH  - Female
MH  - Humans
MH  - Myasthenia Gravis/*complications/*immunology
MH  - *Myasthenia Gravis, Neonatal
MH  - Pregnancy
MH  - Pregnancy Complications/immunology
MH  - Receptor Protein-Tyrosine Kinases/*immunology
MH  - Receptors, Cholinergic/*immunology
OTO - NOTNLM
OT  - Anti-muscle-specific kinase
OT  - Ocular myasthenia gravis
OT  - Pregnancy
OT  - Transient neonatal myasthenia gravis
EDAT- 2017/05/13 06:00
MHDA- 2018/03/17 06:00
CRDT- 2017/05/13 06:00
PHST- 2017/02/10 00:00 [received]
PHST- 2017/03/22 00:00 [revised]
PHST- 2017/03/31 00:00 [accepted]
PHST- 2017/05/13 06:00 [pubmed]
PHST- 2018/03/17 06:00 [medline]
PHST- 2017/05/13 06:00 [entrez]
AID - S0960-8966(17)30063-9 [pii]
AID - 10.1016/j.nmd.2017.03.012 [doi]
PST - ppublish
SO  - Neuromuscul Disord. 2017 Jul;27(7):655-657. doi: 10.1016/j.nmd.2017.03.012. Epub 
      2017 Apr 4.