PMID- 28495095
OWN - NLM
STAT- MEDLINE
DCOM- 20180614
LR  - 20181202
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 972
DP  - 2017 Jun 15
TI  - On-cartridge derivatisation using matrix solid phase dispersion for the 
      determination of cyclamate in foods.
PG  - 46-53
LID - S0003-2670(17)30504-4 [pii]
LID - 10.1016/j.aca.2017.04.032 [doi]
AB  - A novel method for determination of sodium cyclamate in foods was developed. In 
      this method, a syringe was loaded with the homogeneous mixture of the sample, 
      KMnO(4) powder and silica dispersant and used as a matrix solid phase dispersion 
      (MSPD) reactor. As the reactor was infiltrated with small amounts of concentrated 
      HCl, cyclamate was converted to 2-chlorocyclohexanone quickly and effectively 
      within 5 min and determined by HPLC on a reversed-phase column using UV detection 
      at a wavelength of 310 nm. Comparing with the traditional derivatisation in 
      solution, the better clean-up was provided using on-cartridge derivatisation of 
      MSPD, and much time, labor, and expense were saved. The results showed good 
      linearity (r(2) = 0.9998) over the concentration range of 1-500 mg/L. The limit 
      of detection (LOD) and limits of quantification (LOQ) of the cyclamate were 
      0.3 mg/L and 1 mg/L respectively. The recoveries ranged from 91.6% to 101.3% with 
      the relative standard deviations (RSDs) in the range of 2.5%-4.3%.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Li, Jianjun
AU  - Li J
AD  - Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry 
      of Education, Northwest University, Xi'an 710069, China; National Engineering 
      Research Center for Miniaturized Detection Systems, Xi'an 710069, China. 
      Electronic address: bootan12@126.com.
FAU - Liu, Yun
AU  - Liu Y
AD  - College of Food Engineering and Nutritional Science, Shaanxi Normal University, 
      Xi'an 710062, China.
FAU - Liu, Qianping
AU  - Liu Q
AD  - National Engineering Research Center for Miniaturized Detection Systems, Xi'an 
      710069, China.
FAU - Hui, Junfeng
AU  - Hui J
AD  - Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry 
      of Education, Northwest University, Xi'an 710069, China.
FAU - Liu, Yangzi
AU  - Liu Y
AD  - National Engineering Research Center for Miniaturized Detection Systems, Xi'an 
      710069, China.
LA  - eng
PT  - Journal Article
DEP - 20170426
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
RN  - 0 (Cyclamates)
SB  - IM
MH  - Chromatography, High Pressure Liquid
MH  - Cyclamates/*analysis
MH  - *Food Analysis
MH  - Limit of Detection
MH  - *Solid Phase Extraction
OTO - NOTNLM
OT  - 2-chlorocyclohexanone
OT  - Cyclamate
OT  - Derivatisation
OT  - High performance liquid chromatography
OT  - Matrix solid phase dispersion
EDAT- 2017/05/13 06:00
MHDA- 2018/06/15 06:00
CRDT- 2017/05/13 06:00
PHST- 2017/01/03 00:00 [received]
PHST- 2017/04/09 00:00 [revised]
PHST- 2017/04/17 00:00 [accepted]
PHST- 2017/05/13 06:00 [entrez]
PHST- 2017/05/13 06:00 [pubmed]
PHST- 2018/06/15 06:00 [medline]
AID - S0003-2670(17)30504-4 [pii]
AID - 10.1016/j.aca.2017.04.032 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2017 Jun 15;972:46-53. doi: 10.1016/j.aca.2017.04.032. Epub 2017 
      Apr 26.