PMID- 28495595
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20180326
IS  - 1873-5169 (Electronic)
IS  - 0196-9781 (Linking)
VI  - 93
DP  - 2017 Jul
TI  - Low plasma leptin level at admission predicts delirium in critically ill 
      patients: A prospective cohort study.
PG  - 27-32
LID - S0196-9781(17)30193-6 [pii]
LID - 10.1016/j.peptides.2017.05.002 [doi]
AB  - The pathophysiology of delirium remains poorly understood. Low leptin level has 
      been associated with features leading to delirium such as dysregulated immune 
      functions and loss of neuroprotective effects. The purpose of the present study 
      was to investigate the relationship between plasma leptin level at intensive care 
      unit (ICU) entry and subsequent occurrence of delirium in critically ill 
      patients. This single-center prospective cohort study in China allocated 336 
      critically ill patients admitted to ICU between 05/2015 and 05/2016 into a 
      delirium group (n=102) and non-delirium group (n=234) based on whether delirium 
      occurred during their stay at the ICU. Patients were examined at least twice 
      daily and delirium was diagnosed using the Confusion Assessment Method for the 
      ICU (CAM-ICU). Blood samples were obtained after ICU entry. Plasma leptin 
      concentrations were measured by ELISA. Delirium occurred in 30.4% (102/336) of 
      patients. Patients who developed delirium showed significantly lower leptin level 
      at ICU entry than those who did not (6.1+/-3.2 vs. 9.2+/-5.9ng/mL; P<0.001). Low 
      plasma leptin level at ICU entry was independently associated with subsequent 
      occurrence of delirium (OR, 0.865; 95%CI, 0.802-0.934; P<0.001). Other 
      independent risk factors for delirium included increasing age (OR, 1.050; 95%CI, 
      1.020-1.080; P=0.001) and Acute Physiology and Chronic Health Evaluation-II 
      (APACHE-II) score (OR, 1.148; 95%CI, 1.092-1.208; P<0.001). Patients who 
      developed delirium had a prolonged duration of ICU stay and higher mortality. Low 
      plasma leptin level at ICU entry was associated with the occurrence of delirium 
      in critically ill patients.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Li, Guicheng
AU  - Li G
AD  - Department of Critical Care Medicine, Nanfang Hospital, Southern Medical 
      University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong 510515, China; 
      Department of Critical Care Medicine, The First People's Hospital of Chenzhou, 
      Luo Jia Jin Street 102, Chenzhou, Hunan 423000, China.
FAU - Lei, Xiaobao
AU  - Lei X
AD  - Department of Critical Care Medicine, The First People's Hospital of Chenzhou, 
      Luo Jia Jin Street 102, Chenzhou, Hunan 423000, China.
FAU - Ai, Chenmu
AU  - Ai C
AD  - Department of Critical Care Medicine, The First People's Hospital of Chenzhou, 
      Luo Jia Jin Street 102, Chenzhou, Hunan 423000, China.
FAU - Li, Tao
AU  - Li T
AD  - Institute of Translational Medicine, University of Nanhua, Luo Jia Jin Street 
      102, Chenzhou, Hunan 423000, China.
FAU - Chen, Zhongqing
AU  - Chen Z
AD  - Department of Critical Care Medicine, Nanfang Hospital, Southern Medical 
      University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong 510515, China. 
      Electronic address: zhongqingchen2008@163.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170508
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 0 (Biomarkers)
RN  - 0 (Leptin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - China
MH  - Cohort Studies
MH  - Critical Illness
MH  - Delirium/blood/*diagnosis/mortality
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Intensive Care Units
MH  - Length of Stay
MH  - Leptin/*blood
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Critically ill
OT  - Delirium
OT  - Intensive care
OT  - Leptin
EDAT- 2017/05/13 06:00
MHDA- 2018/03/27 06:00
CRDT- 2017/05/13 06:00
PHST- 2017/02/21 00:00 [received]
PHST- 2017/05/05 00:00 [revised]
PHST- 2017/05/05 00:00 [accepted]
PHST- 2017/05/13 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2017/05/13 06:00 [entrez]
AID - S0196-9781(17)30193-6 [pii]
AID - 10.1016/j.peptides.2017.05.002 [doi]
PST - ppublish
SO  - Peptides. 2017 Jul;93:27-32. doi: 10.1016/j.peptides.2017.05.002. Epub 2017 May 
      8.