PMID- 28495599
OWN - NLM
STAT- MEDLINE
DCOM- 20180417
LR  - 20180417
IS  - 1873-3514 (Electronic)
IS  - 0028-3932 (Linking)
VI  - 102
DP  - 2017 Jul 28
TI  - Effects of the Brain-Derived Neurotrophic Factor Val66Met polymorphism and 
      resting brain functional connectivity on individual differences in tactile 
      cognitive performance in healthy young adults.
PG  - 170-176
LID - S0028-3932(17)30177-X [pii]
LID - 10.1016/j.neuropsychologia.2017.05.011 [doi]
AB  - Cognitive processes involve input from multiple sensory modalities and obvious 
      differences in the level of cognitive function can be observed between 
      individuals. Evidence to date understanding the biological basis of tactile 
      cognitive variability, however, is limited compared with other forms of sensory 
      cognition. Data from auditory and visual cognition research suggest that 
      variations in both genetics and intrinsic brain function might contribute to 
      individual differences in tactile cognitive performance. In the present study, by 
      using the tactual performance test (TPT), a widely used neuropsychological 
      assessment tool, we investigated the effects of the brain-derived neurotrophic 
      factor (BDNF) Val66Met polymorphism and resting-state brain functional 
      connectivity (FC) on interindividual variability in TPT performance in healthy, 
      young Chinese adults. Our results showed that the BDNF genotypes and 
      resting-state FC had significant effects on the variability in TPT performance, 
      together accounting for 32.5% and 19.1% of the variance on TPT total score and 
      Memory subitem score respectively. Having fewer Met alleles, stronger 
      anticorrelations between left posterior superior temporal gyrus and somatosensory 
      areas (right postcentral gyrus and right parietal operculum cortex), and greater 
      positive correlation between left parietal operculum cortex and left central 
      opercular cortex, all correspond with better performance of TPT task. And FC 
      between left parietal operculum cortex and left central opercular cortex might be 
      a mediator of the relationship between BDNF genotypes and Memory subitem score. 
      These data demonstrate a novel contribution of intrinsic brain function to 
      tactile cognitive capacity, and further confirm the genetic basis of tactile 
      cognition. Our findings might also explain the interindividual differences in 
      cognitive ability observed in those who are blind and/or deaf from a new 
      perspective.
CI  - Copyright (c) 2017. Published by Elsevier Ltd.
FAU - Yang, Xuejuan
AU  - Yang X
AD  - Engineering Research Center of Molecular and Neuro Imaging of the Ministry of 
      Education, School of Life Science and Technology, Xidian University, Xi'an, 
      Shaanxi 710071, China.
FAU - Xu, Ziliang
AU  - Xu Z
AD  - Engineering Research Center of Molecular and Neuro Imaging of the Ministry of 
      Education, School of Life Science and Technology, Xidian University, Xi'an, 
      Shaanxi 710071, China.
FAU - Liu, Lin
AU  - Liu L
AD  - Engineering Research Center of Molecular and Neuro Imaging of the Ministry of 
      Education, School of Life Science and Technology, Xidian University, Xi'an, 
      Shaanxi 710071, China.
FAU - Liu, Peng
AU  - Liu P
AD  - Engineering Research Center of Molecular and Neuro Imaging of the Ministry of 
      Education, School of Life Science and Technology, Xidian University, Xi'an, 
      Shaanxi 710071, China; School of Computer and Communication, Lanzhou University 
      of Technology, Lanzhou, Gansu 710050, China.
FAU - Sun, Jinbo
AU  - Sun J
AD  - Engineering Research Center of Molecular and Neuro Imaging of the Ministry of 
      Education, School of Life Science and Technology, Xidian University, Xi'an, 
      Shaanxi 710071, China.
FAU - Jin, Lingmin
AU  - Jin L
AD  - Engineering Research Center of Molecular and Neuro Imaging of the Ministry of 
      Education, School of Life Science and Technology, Xidian University, Xi'an, 
      Shaanxi 710071, China.
FAU - Zhu, Yuanqiang
AU  - Zhu Y
AD  - Engineering Research Center of Molecular and Neuro Imaging of the Ministry of 
      Education, School of Life Science and Technology, Xidian University, Xi'an, 
      Shaanxi 710071, China.
FAU - Fei, Ningbo
AU  - Fei N
AD  - Engineering Research Center of Molecular and Neuro Imaging of the Ministry of 
      Education, School of Life Science and Technology, Xidian University, Xi'an, 
      Shaanxi 710071, China.
FAU - Qin, Wei
AU  - Qin W
AD  - Engineering Research Center of Molecular and Neuro Imaging of the Ministry of 
      Education, School of Life Science and Technology, Xidian University, Xi'an, 
      Shaanxi 710071, China. Electronic address: wqin@xidian.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170508
PL  - England
TA  - Neuropsychologia
JT  - Neuropsychologia
JID - 0020713
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/diagnostic imaging/*physiology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cognition/*physiology
MH  - Female
MH  - Genotype
MH  - Healthy Volunteers
MH  - Humans
MH  - *Individuality
MH  - Linear Models
MH  - Male
MH  - Methionine/genetics
MH  - Neural Pathways/physiology
MH  - Neuropsychological Tests
MH  - Polymorphism, Genetic/*genetics
MH  - Rest
MH  - Touch/*genetics
MH  - Valine/genetics
MH  - Young Adult
OTO - NOTNLM
OT  - BDNF
OT  - Brain functional connectivity
OT  - Polymorphism
OT  - Resting-state
OT  - Tactile cognition
EDAT- 2017/05/13 06:00
MHDA- 2018/04/18 06:00
CRDT- 2017/05/13 06:00
PHST- 2016/12/09 00:00 [received]
PHST- 2017/04/27 00:00 [revised]
PHST- 2017/05/07 00:00 [accepted]
PHST- 2017/05/13 06:00 [pubmed]
PHST- 2018/04/18 06:00 [medline]
PHST- 2017/05/13 06:00 [entrez]
AID - S0028-3932(17)30177-X [pii]
AID - 10.1016/j.neuropsychologia.2017.05.011 [doi]
PST - ppublish
SO  - Neuropsychologia. 2017 Jul 28;102:170-176. doi: 
      10.1016/j.neuropsychologia.2017.05.011. Epub 2017 May 8.