PMID- 28495608
OWN - NLM
STAT- MEDLINE
DCOM- 20180403
LR  - 20180502
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 331
DP  - 2017 Jul 28
TI  - Short-term caloric restriction exerts neuroprotective effects following mild 
      traumatic brain injury by promoting autophagy and inhibiting astrocyte 
      activation.
PG  - 135-142
LID - S0166-4328(17)30217-6 [pii]
LID - 10.1016/j.bbr.2017.04.024 [doi]
AB  - Cognitive deficits may occur after mild traumatic brain injury (mTBI), but 
      effective treatment modalities are presently unavailable. Caloric restriction 
      (CR) has beneficial effects on neurodegenerative diseases and brain injury. 
      However, the underlying mechanisms have not yet been clearly defined. Therefore, 
      the aim of the present study was to investigate the short-term effects of CR 
      treatment on cognitive function in mice after mTBI. Forty-five 12-week-old 
      C57/BL6 mice were subjected to closed-head mTBI using a weight drop device. The 
      mice were then randomly divided into three groups according to their diet for 30 
      days: the normal calorie group (mTBI+NC group, n=15), the caloric restriction 
      group (mTBI+CR group, n=15), and the high energy group (mTBI+HE group, n=15). 
      After 30 days, the Morris water maze test was performed to evaluate learning 
      abilities. Nissl staining, immunohistochemistry, and western blotting were used 
      to monitor pathological changes and changes in autophagy-associated proteins in 
      the hippocampus. The average escape latency was significantly shorter in the 
      mTBI+CR group than in the mTBI+NC and mTBI+HE groups, and the number of target 
      platform crossings in the mTBI+CR group was significantly higher than in the 
      other two groups. In the hippocampus, the expression of GFAP and mTOR was 
      increased in the mTBI+HE group and decreased in the mTBI+CR group. Conversely, 
      the expression of LC3B was decreased in the mTBI+HE group and increased in the 
      mTBI+CR group. Our findings suggest that short-term CR after mTBI may ameliorate 
      cognitive dysfunction induced by mTBI by increasing the level of autophagy and 
      suppressing astrocyte activation.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Liu, Yuan
AU  - Liu Y
AD  - Central Laboratory, Xuan Wu Hospital, Capital Medical University, Beijing 
      Institute for Brain Disorders, Center of Alzheimer's Disease, Beijing 100053, 
      China.
FAU - Wang, Rong
AU  - Wang R
AD  - Central Laboratory, Xuan Wu Hospital, Capital Medical University, Beijing 
      Institute for Brain Disorders, Center of Alzheimer's Disease, Beijing 100053, 
      China; Beijing Geriatric Medical Research Center, Key Laboratory for 
      Neurodegenerative Disease of Ministry of Education, Beijing 100053, China. 
      Electronic address: rong_wang72@126.com.
FAU - Zhao, Zhiwei
AU  - Zhao Z
AD  - Central Laboratory, Xuan Wu Hospital, Capital Medical University, Beijing 
      Institute for Brain Disorders, Center of Alzheimer's Disease, Beijing 100053, 
      China.
FAU - Dong, Wen
AU  - Dong W
AD  - Central Laboratory, Xuan Wu Hospital, Capital Medical University, Beijing 
      Institute for Brain Disorders, Center of Alzheimer's Disease, Beijing 100053, 
      China.
FAU - Zhang, Xu
AU  - Zhang X
AD  - Central Laboratory, Xuan Wu Hospital, Capital Medical University, Beijing 
      Institute for Brain Disorders, Center of Alzheimer's Disease, Beijing 100053, 
      China.
FAU - Chen, Xi
AU  - Chen X
AD  - Department of Infectious Diseases, Chifeng City Hospital, Chifeng Clinical 
      Medicine College of Inner Mongolia Medical University, Chifeng, Inner Mongolia 
      Autonomous Region, 024000, China.
FAU - Ma, Lina
AU  - Ma L
AD  - Department of Geriatrics, Xuan Wu Hospital, Capital Medical University, Beijing 
      100053, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170508
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - Animals
MH  - Astrocytes/*metabolism/pathology
MH  - *Autophagy/physiology
MH  - Brain Concussion/*metabolism
MH  - Brain Injuries/pathology/*prevention & control
MH  - *Caloric Restriction
MH  - Disease Models, Animal
MH  - Energy Intake/*physiology
MH  - Male
MH  - Maze Learning/drug effects
MH  - Mice, Inbred C57BL
MH  - Neurogenesis/physiology
MH  - Neuroprotective Agents/pharmacology
MH  - Time Factors
OTO - NOTNLM
OT  - Autophagy
OT  - Caloric restriction
OT  - Learning ability
OT  - Mild traumatic brain injury
EDAT- 2017/05/13 06:00
MHDA- 2018/04/04 06:00
CRDT- 2017/05/13 06:00
PHST- 2017/02/02 00:00 [received]
PHST- 2017/04/08 00:00 [revised]
PHST- 2017/04/11 00:00 [accepted]
PHST- 2017/05/13 06:00 [pubmed]
PHST- 2018/04/04 06:00 [medline]
PHST- 2017/05/13 06:00 [entrez]
AID - S0166-4328(17)30217-6 [pii]
AID - 10.1016/j.bbr.2017.04.024 [doi]
PST - ppublish
SO  - Behav Brain Res. 2017 Jul 28;331:135-142. doi: 10.1016/j.bbr.2017.04.024. Epub 
      2017 May 8.