PMID- 28496116
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20220331
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 May 11
TI  - Antinociceptive effects of caloric restriction on post-incisional pain in 
      nonobese rats.
PG  - 1805
LID - 10.1038/s41598-017-01909-8 [doi]
LID - 1805
AB  - Caloric restriction (CR) increases lifespan, retards physiological signs of 
      aging, and delays a variety of diseases. Reduction of inflammatory response was 
      proposed as one of the molecular mechanisms for how CR exerts beneficial effects. 
      The present study investigated the effects of CR on postoperative pain in rats. 
      Adult nonobese rats were divided into two dietary groups, an ad libitum fed group 
      (AL) and a caloric restriction group (CR) that was provided with 60% of the food 
      intake of AL rats. After 6 weeks, the effects of CR on pain behaviors and 
      inflammation induced by plantar incision were examined. CR rats displayed 
      significantly reduced nonevoked pain, mechanical allodynia and thermal 
      hyperalgesia induced by incision, and showed decreased levels of pro-inflammatory 
      cytokines in serum, peri-incisional skin tissue and ipsilateral spinal cord 
      dorsal horn at 6 h and 24 h after incision. The analgesic efficiency of parecoxib 
      and morphine, two agents widely used for the management of postoperative pain 
      clinically, was reinforced by CR. Together, CR generates antinociceptive effects 
      on postoperative incisional pain in rats, perhaps providing some improvement of 
      QOL in patients with postoperative pain, and the beneficial effects may be 
      attributable to the inhibition of excessive inflammation induced by surgical 
      injury.
FAU - Liu, Yue
AU  - Liu Y
AD  - Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical School of 
      Nanjing University, Nanjing, 210008, Jiangsu province, China.
FAU - Ni, Yuan
AU  - Ni Y
AD  - Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical School of 
      Nanjing University, Nanjing, 210008, Jiangsu province, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical School of 
      Nanjing University, Nanjing, 210008, Jiangsu province, China.
FAU - Sun, Yu-E
AU  - Sun YE
AD  - Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical School of 
      Nanjing University, Nanjing, 210008, Jiangsu province, China.
FAU - Ma, Zhengliang
AU  - Ma Z
AD  - Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical School of 
      Nanjing University, Nanjing, 210008, Jiangsu province, China. 
      mazhengliang1964@nju.edu.cn.
FAU - Gu, Xiaoping
AU  - Gu X
AD  - Department of Anesthesiology, Affiliated Drum Tower Hospital of Medical School of 
      Nanjing University, Nanjing, 210008, Jiangsu province, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170511
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Analgesics)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Analgesics/pharmacology
MH  - Animals
MH  - Behavior, Animal
MH  - Body Weight
MH  - *Caloric Restriction
MH  - Cytokines/metabolism
MH  - Inflammation Mediators/metabolism
MH  - Male
MH  - Motor Activity
MH  - *Nociception
MH  - *Nociceptive Pain/diagnosis/etiology/metabolism
MH  - *Pain, Postoperative/diagnosis/metabolism
MH  - Rats
MH  - Spinal Cord Dorsal Horn/metabolism/physiopathology
PMC - PMC5431843
COIS- The authors declare that they have no competing interests.
EDAT- 2017/05/13 06:00
MHDA- 2018/12/12 06:00
PMCR- 2017/05/11
CRDT- 2017/05/13 06:00
PHST- 2017/01/10 00:00 [received]
PHST- 2017/04/03 00:00 [accepted]
PHST- 2017/05/13 06:00 [entrez]
PHST- 2017/05/13 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2017/05/11 00:00 [pmc-release]
AID - 10.1038/s41598-017-01909-8 [pii]
AID - 1909 [pii]
AID - 10.1038/s41598-017-01909-8 [doi]
PST - epublish
SO  - Sci Rep. 2017 May 11;7(1):1805. doi: 10.1038/s41598-017-01909-8.