PMID- 28496358
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1178-7090 (Print)
IS  - 1178-7090 (Electronic)
IS  - 1178-7090 (Linking)
VI  - 10
DP  - 2017
TI  - Analgesic efficacy, adverse effects, and safety of oxycodone administered as 
      continuous intravenous infusion in patients after total hip arthroplasty.
PG  - 1027-1032
LID - 10.2147/JPR.S125449 [doi]
AB  - BACKGROUND: Total hip arthroplasty (THA) causes extensive tissue damage and 
      severe pain. This study aimed to assess the analgesic efficacy, adverse effects 
      (AEs), and safety of continuous intravenous (iv) oxycodone infusion with 
      ketoprofen (injected into the iv line) in patients after THA, and to assay serum 
      oxycodone levels. PATIENTS AND METHODS: Fourteen patients, aged 59‒82 years with 
      American Society of Anesthesiologists (ASA) classification I or III, underwent 
      THA with intrathecal analgesia and sedation induced by iv propofol. After the 
      surgery, oxycodone (continuous iv infusion) at a dose of 1 mg/h (five patients) 
      or 2 mg/h (nine patients) with 100 mg ketoprofen (injected into the iv line) was 
      administered to each patient every 12 h. Pain was assessed using a numerical 
      rating scale (NRS: 0 - no pain, 10 - the most severe pain) at rest and during 
      movement. AEs, including hemodynamic unsteadiness, nausea, vomiting, pruritus, 
      cognitive impairment, and respiratory depression, were registered during the 
      first 24 h after surgery. RESULTS: Oxycodone (continuous iv infusion) at a dose 
      of 2 mg/h with ketoprofen (100 mg) administered every 12 h provided satisfactory 
      analgesia in all nine patients without the need of rescue analgesics within the 
      first 24 h after THA. In three out of five patients, oxycodone at 1 mg/h was 
      effective. Oxycodone did not induce drowsiness, vomiting, pruritus, respiratory 
      depression, or changes in blood pressure. Bradycardia appeared in two patients, 
      and nausea was observed in one patient. CONCLUSION: Oxycodone infusion with 
      ketoprofen administered by iv is effective in patients after THA. Intravenous 
      infusion of oxycodone is a predictable, stable, and safe method of drug 
      administration.
FAU - Olczak, Bogumil
AU  - Olczak B
AD  - Department of Anesthesiology, Jozef Strus Multiprofile Municipal Hospital.
FAU - Kowalski, Grzegorz
AU  - Kowalski G
AD  - Department of Anesthesiology, Jozef Strus Multiprofile Municipal Hospital.
AD  - Department of Palliative Medicine, Poznan University of Medical Sciences.
FAU - Leppert, Wojciech
AU  - Leppert W
AD  - Department of Palliative Medicine, Poznan University of Medical Sciences.
FAU - Zaporowska-Stachowiak, Iwona
AU  - Zaporowska-Stachowiak I
AD  - Department of Pharmacology, Poznan University of Medical Sciences, Poland.
FAU - Wieczorowska-Tobis, Katarzyna
AU  - Wieczorowska-Tobis K
AD  - Department of Palliative Medicine, Poznan University of Medical Sciences.
LA  - eng
PT  - Journal Article
DEP - 20170504
PL  - New Zealand
TA  - J Pain Res
JT  - Journal of pain research
JID - 101540514
PMC - PMC5422568
OTO - NOTNLM
OT  - adverse effects
OT  - analgesia
OT  - opioid
OT  - oxycodone
OT  - pain
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2017/05/13 06:00
MHDA- 2017/05/13 06:01
PMCR- 2017/05/04
CRDT- 2017/05/13 06:00
PHST- 2017/05/13 06:00 [entrez]
PHST- 2017/05/13 06:00 [pubmed]
PHST- 2017/05/13 06:01 [medline]
PHST- 2017/05/04 00:00 [pmc-release]
AID - jpr-10-1027 [pii]
AID - 10.2147/JPR.S125449 [doi]
PST - epublish
SO  - J Pain Res. 2017 May 4;10:1027-1032. doi: 10.2147/JPR.S125449. eCollection 2017.