PMID- 28496523
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240404
IS  - 1759-9954 (Print)
IS  - 1759-9962 (Electronic)
IS  - 1759-9954 (Linking)
VI  - 8
IP  - 1
DP  - 2017 Jan 1
TI  - Probing the causes of thermal hysteresis using tunable N(agg) micelles with 
      linear and brush-like thermoresponsive coronas.
PG  - 233-244
LID - 10.1039/c6py01191h [doi]
AB  - Self-assembled thermoresponsive polymers in aqueous solution have great potential 
      as smart, switchable materials for use in biomedical applications. In recent 
      years, attention has turned to the reversibility of these polymers' thermal 
      transitions, which has led to debate over what factors influence discrepancies in 
      the transition temperature when heating the system compared to the temperature 
      obtained when cooling the system, known as the thermal hysteresis. Herein, we 
      synthesize micelles with tunable aggregation numbers (N(agg)) whose cores contain 
      poly(n-butyl acrylate-co-N,N-dimethylacrylamide) (p(nBA-co-DMA)) and four 
      different thermoresponsive corona blocks, namely poly(N-isopropylacrylamide) 
      (pNIPAM), poly(N,N-diethylacrylamide) (pDEAm), poly(diethylene glycol monomethyl 
      ether methacrylate) (pDEGMA) and poly(oligo(ethylene glycol) monomethyl ether 
      methacrylate) (pOEGMA). By studying their thermoresponsive behavior, we elucidate 
      the effects of changing numerous important characteristics both in the 
      thermoresponsive chain chemistry and architecture, and in the structure of their 
      self-assemblies. Our findings demonstrate large deviations in the reversibility 
      between the self-assemblies and the corresponding thermoresponsive homopolymers; 
      specifically we find that micelles whose corona consist of polymers with a 
      brush-like architecture (pDEGMA and pOEGMA) exhibit irreversible phase 
      transitions at a critical chain density. These results lead to a deeper 
      understanding of stimuli-responsive self-assemblies and demonstrate the potential 
      of tunable N(agg) micelles for uncovering structure-property relationships in 
      responsive polymer systems.
FAU - Blackman, L D
AU  - Blackman LD
AD  - Dept. of Chemistry , University of Warwick , Gibbet Hill Road , Coventry , CV4 
      7AL , UK . Email: r.k.o-reilly@warwick.ac.uk.
FAU - Gibson, M I
AU  - Gibson MI
AD  - Dept. of Chemistry , University of Warwick , Gibbet Hill Road , Coventry , CV4 
      7AL , UK . Email: r.k.o-reilly@warwick.ac.uk.
AD  - Warwick Medical School , University of Warwick , Gibbet Hill Road , Coventry , 
      CV4 7AL , UK . Email: m.i.gibson@warwick.ac.uk.
FAU - O'Reilly, R K
AU  - O'Reilly RK
AD  - Dept. of Chemistry , University of Warwick , Gibbet Hill Road , Coventry , CV4 
      7AL , UK . Email: r.k.o-reilly@warwick.ac.uk.
LA  - eng
PT  - Journal Article
DEP - 20160809
PL  - England
TA  - Polym Chem
JT  - Polymer chemistry
JID - 101562526
PMC - PMC5361139
EDAT- 2017/05/13 06:00
MHDA- 2017/05/13 06:01
PMCR- 2016/08/09
CRDT- 2017/05/13 06:00
PHST- 2016/07/11 00:00 [received]
PHST- 2016/07/30 00:00 [accepted]
PHST- 2017/05/13 06:00 [entrez]
PHST- 2017/05/13 06:00 [pubmed]
PHST- 2017/05/13 06:01 [medline]
PHST- 2016/08/09 00:00 [pmc-release]
AID - c6py01191h [pii]
AID - 10.1039/c6py01191h [doi]
PST - ppublish
SO  - Polym Chem. 2017 Jan 1;8(1):233-244. doi: 10.1039/c6py01191h. Epub 2016 Aug 9.