PMID- 28497081
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2345-2781 (Print)
IS  - 2345-2781 (Electronic)
IS  - 2345-2781 (Linking)
VI  - 6
IP  - 2
DP  - 2017
TI  - Relationship between serum irisin, glycemic indices, and renal function in type 2 
      diabetic patients.
PG  - 88-92
LID - 10.15171/jrip.2017.17 [doi]
AB  - Introduction: Irisin is a novel peptide that plays notable role in human and 
      animal biology and physiology. It has been reported that irisin may improve 
      insulin resistance and related disturbances. Objectives: The aim of this 
      investigation was to assess the relationship between serum irisin, glycemic 
      indices, and renal function in diabetic subjects. Patients and Methods: In this 
      cross-sectional study, a total of 102 type 2 diabetes mellitus (T2DM) patients 
      were recruited. Blood biochemical parameters, including fasting plasma sugar 
      (FBS), glycosylated hemoglobin (HbA(1C)), serum uric acid (sUA), creatinine 
      concentration and glomerular filtration rate (GFR) were measured. All statistical 
      analysis was performed with SPSS 16.0. Results: There was a positive correlation 
      between irisin and age (P=0.05, r=0.19) and a negative correlation between irisin 
      and body mass index (BMI) (P=0.01, r=-0.25) was detected. There was a significant 
      difference of serum irisin level between patients with normal and abnormal FBS 
      too. Conclusion: In this study we found, irisin concentration was increased with 
      age, decreased with BMI, and it was higher in subject with abnormal FBS. Thus 
      further research is needed to provide inclusive understanding of irisin 
      associated physiological effects and possible implications in clinical 
      conditions.
FAU - Mahmoodnia, Leila
AU  - Mahmoodnia L
AD  - Department of Internal Medicine, Shahrekord University of Medical Sciences, 
      Shahrekord, Iran.
FAU - Sadoughi, Maryam
AU  - Sadoughi M
AD  - Department of Internal Medicine, Shahrekord University of Medical Sciences, 
      Shahrekord, Iran.
FAU - Ahmadi, Ali
AU  - Ahmadi A
AD  - Department of Epidemiology and Biostatistics, Shahrekord University of Medical 
      Sciences, Shahrekord, Iran.
FAU - Kafeshani, Marzieh
AU  - Kafeshani M
AD  - School of Nutrition & Food Science, Isfahan University of Medical Sciences, 
      Isfahan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20161120
PL  - Iran
TA  - J Renal Inj Prev
JT  - Journal of renal injury prevention
JID - 101642540
PMC - PMC5423290
OTO - NOTNLM
OT  - Body mass index
OT  - Irisin
OT  - Type 2 diabetic patients
EDAT- 2017/05/13 06:00
MHDA- 2017/05/13 06:01
PMCR- 2016/11/20
CRDT- 2017/05/13 06:00
PHST- 2016/08/23 00:00 [received]
PHST- 2016/10/28 00:00 [accepted]
PHST- 2017/05/13 06:00 [entrez]
PHST- 2017/05/13 06:00 [pubmed]
PHST- 2017/05/13 06:01 [medline]
PHST- 2016/11/20 00:00 [pmc-release]
AID - 10.15171/jrip.2017.17 [doi]
PST - epublish
SO  - J Renal Inj Prev. 2016 Nov 20;6(2):88-92. doi: 10.15171/jrip.2017.17. eCollection 
      2017.