PMID- 28499034
OWN - NLM
STAT- MEDLINE
DCOM- 20180518
LR  - 20180518
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Linking)
VI  - 57
IP  - 3
DP  - 2018 Mar 1
TI  - Functional disability and its predictors in systemic sclerosis: a study from the 
      DeSScipher project within the EUSTAR group.
PG  - 441-450
LID - 10.1093/rheumatology/kex182 [doi]
AB  - OBJECTIVES: The multisystem manifestations of SSc can greatly impact patients' 
      quality of life. The aim of this study was to identify factors associated with 
      disability in SSc. METHODS: SSc patients from the prospective DeSScipher cohort 
      who had completed the scleroderma health assessment questionnaire (SHAQ), a 
      disability score that combines the health assessment questionnaire and five 
      visual analogue scales, were included in this analysis. The effect of factors 
      possibly associated with disability was analysed with multiple linear 
      regressions. RESULTS: The mean SHAQ and HAQ scores of the 944 patients included 
      were 0.87 (s.d. = 0.66) and 0.92 (s.d. = 0.78); 59% of the patients were in the 
      mild to moderate difficulty SHAQ category (0 ⩽ SHAQ < 1), 34% in the moderate to 
      severe disability category (1 ⩽ SHAQ < 2) and 7% in the severe to very severe 
      disability category (2 ⩽ SHAQ ⩽ 3). The means of the visual analogue scales 
      scores were in order of magnitude: overall disease severity (37 mm), RP (31 mm), 
      pulmonary symptoms (24 mm), gastrointestinal symptoms (20 mm) and digital ulcers 
      (19 mm). In multiple regression, the main factors associated with high SHAQ 
      scores were the presence of dyspnoea [modified New York Heart Association (NYHA) 
      class IV (regression coefficient B = 0.62), modified NYHA class III (B = 0.53) 
      and modified NYHA class II (B = 0.21; all vs modified NYHA class I)], FM (B = 
      0.37), muscle weakness (B = 0.27), digital ulcers (B = 0.20) and gastrointestinal 
      symptoms (oesophageal symptoms, B = 0.16; stomach symptoms, B = 0.15; intestinal 
      symptoms, B = 0.15). CONCLUSION: SSc patients perceive dyspnoea, pain, digital 
      ulcers, muscle weakness and gastrointestinal symptoms as the main factors driving 
      their level of disability, unlike physicians who emphasize objective measures of 
      disability.
CI  - (c) The Author 2017. Published by Oxford University Press on behalf of the British 
      Society for Rheumatology. All rights reserved. For Permissions, please email: 
      journals.permissions@oup.com
FAU - Jaeger, Veronika K
AU  - Jaeger VK
AD  - Department of Rheumatology, University Hospital Basel, Basel.
FAU - Distler, Oliver
AU  - Distler O
AD  - Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland.
FAU - Maurer, Britta
AU  - Maurer B
AD  - Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland.
FAU - Czirjak, Laszlo
AU  - Czirjak L
AD  - Department of Rheumatology and Immunology, Medical Center, University of Pecs, 
      Pecs, Hungary.
FAU - Lorand, Veronika
AU  - Lorand V
AD  - Department of Rheumatology and Immunology, Medical Center, University of Pecs, 
      Pecs, Hungary.
FAU - Valentini, Gabriele
AU  - Valentini G
AD  - Department of Rheumatology, Second University of Naples, Naples, Italy.
FAU - Vettori, Serena
AU  - Vettori S
AD  - Department of Rheumatology, Second University of Naples, Naples, Italy.
FAU - Del Galdo, Francesco
AU  - Del Galdo F
AD  - NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS 
      Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University 
      of Leeds, Leeds.
FAU - Abignano, Giuseppina
AU  - Abignano G
AD  - NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS 
      Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University 
      of Leeds, Leeds.
FAU - Denton, Christopher
AU  - Denton C
AD  - Department of Rheumatology, University College London, Royal Free Hospital, 
      London, UK.
FAU - Nihtyanova, Svetlana
AU  - Nihtyanova S
AD  - Department of Rheumatology, University College London, Royal Free Hospital, 
      London, UK.
FAU - Allanore, Yannick
AU  - Allanore Y
AD  - Department of Rheumatology, University of Paris Descartes, Paris, France.
FAU - Avouac, Jerome
AU  - Avouac J
AD  - Department of Rheumatology, University of Paris Descartes, Paris, France.
FAU - Riemekasten, Gabriele
AU  - Riemekasten G
AD  - Department of Rheumatology, University Clinic Schleswig-Holstein, Lubeck.
FAU - Siegert, Elise
AU  - Siegert E
AD  - Department of Rheumatology and Clinical Immunology, University Hospital Charite.
FAU - Huscher, Dorte
AU  - Huscher D
AD  - German Rheumatism Research Centre, Berlin, Germany.
FAU - Matucci-Cerinic, Marco
AU  - Matucci-Cerinic M
AD  - Department of Rheumatology, University of Florence, Florence, Italy.
FAU - Guiducci, Serena
AU  - Guiducci S
AD  - Department of Rheumatology, University of Florence, Florence, Italy.
FAU - Frerix, Marc
AU  - Frerix M
AD  - Department of Rheumatology and Clinical Immunology, Justus-Liebig University 
      Giessen, Kerckhoff Clinic Bad Nauheim, Bad Nauheim, Germany.
FAU - Tarner, Ingo H
AU  - Tarner IH
AD  - Department of Rheumatology and Clinical Immunology, Justus-Liebig University 
      Giessen, Kerckhoff Clinic Bad Nauheim, Bad Nauheim, Germany.
FAU - Garay Toth, Beata
AU  - Garay Toth B
AD  - Federation of European Scleroderma Associations Aisbl, Budapest, Hungary.
FAU - Fankhauser, Beat
AU  - Fankhauser B
AD  - new-win SW Solutions AG, Suhr, Switzerland.
FAU - Umbricht, Jorg
AU  - Umbricht J
AD  - new-win SW Solutions AG, Suhr, Switzerland.
FAU - Zakharova, Anastasia
AU  - Zakharova A
AD  - VA Nasonova Institute of Rheumatology, Moscow, Russian Federation.
FAU - Mihai, Carina
AU  - Mihai C
AD  - Department of Internal Medicine and Rheumatology, Dr Ion Cantacuzino Clinical 
      Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
FAU - Cozzi, Franco
AU  - Cozzi F
AD  - Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy.
FAU - Yavuz, Sule
AU  - Yavuz S
AD  - Department of Rheumatology, University of Marmara, Altunizade-Istanbul, Turkey.
FAU - Hunzelmann, Nicolas
AU  - Hunzelmann N
AD  - Department of Dermatology, University of Cologne, Cologne, Germany.
FAU - Rednic, Simona
AU  - Rednic S
AD  - Clinica Reumatologie, University of Medicine & Pharmacy, Cluj-Napoca, Romania.
FAU - Vacca, Alessandra
AU  - Vacca A
AD  - II Chair of Rheumatology, University of Cagliari-Policlinico Universitario, 
      Monserrato, Italy.
FAU - Schmeiser, Tim
AU  - Schmeiser T
AD  - Department of Rheumatology and Immunology, Krankenhaus St Josef, Wuppertal, 
      Germany.
FAU - Riccieri, Valeria
AU  - Riccieri V
AD  - Divisione di Reumatologia, Universita di Roma La Sapienza, Roma, Italy.
FAU - Garcia de la Pena Lefebvre, Paloma
AU  - Garcia de la Pena Lefebvre P
AD  - Servicio de Reumatologia, Hospital Universitario Madrid Norte Sanchinarro, 
      Madrid, Spain.
FAU - Gabrielli, Armando
AU  - Gabrielli A
AD  - Istituto di Clinica Medica Generale, Ematologia ed Immunologia Clinica, 
      Universita Politecnica delle Marche, Ancona, Italy.
FAU - Krummel-Lorenz, Brigitte
AU  - Krummel-Lorenz B
AD  - Endokrinologikum Frankfurt, Frankfurt, Germany.
FAU - Martinovic, Duska
AU  - Martinovic D
AD  - Division of Rheumatology, University Hospital of Split, Split, Croatia.
FAU - Ancuta, Codrina
AU  - Ancuta C
AD  - Rheumatology 2 Department, Clinical Rehabilitation Hospital, University of 
      Medicine and Pharmacy 'Grigore T. Popa', Iasi, Romania.
FAU - Smith, Vanessa
AU  - Smith V
AD  - Faculty of Internal Medicine, Ghent University, Ghent, Belgium.
FAU - Muller-Ladner, Ulf
AU  - Muller-Ladner U
AD  - Department of Rheumatology and Clinical Immunology, Justus-Liebig University 
      Giessen, Kerckhoff Clinic Bad Nauheim, Bad Nauheim, Germany.
FAU - Walker, Ulrich A
AU  - Walker UA
AD  - Department of Rheumatology, University Hospital Basel, Basel.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
SB  - IM
CIN - Rheumatology (Oxford). 2018 Mar 1;57(3):410-413. PMID: 29272533
MH  - *Activities of Daily Living
MH  - *Disability Evaluation
MH  - Europe
MH  - Gastrointestinal Diseases/etiology/physiopathology
MH  - Humans
MH  - Hypertension, Pulmonary/etiology/physiopathology
MH  - Longitudinal Studies
MH  - Muscle Weakness/etiology/physiopathology
MH  - Pain Measurement
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Regression Analysis
MH  - Risk Factors
MH  - Scleroderma, Systemic/complications/*physiopathology/psychology
MH  - Severity of Illness Index
MH  - *Sickness Impact Profile
MH  - Skin Ulcer/etiology/physiopathology
EDAT- 2017/05/13 06:00
MHDA- 2018/05/19 06:00
CRDT- 2017/05/13 06:00
PHST- 2016/09/27 00:00 [received]
PHST- 2017/05/13 06:00 [pubmed]
PHST- 2018/05/19 06:00 [medline]
PHST- 2017/05/13 06:00 [entrez]
AID - 3814397 [pii]
AID - 10.1093/rheumatology/kex182 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2018 Mar 1;57(3):441-450. doi: 
      10.1093/rheumatology/kex182.