PMID- 28499612
OWN - NLM
STAT- MEDLINE
DCOM- 20170626
LR  - 20170626
IS  - 1879-3169 (Electronic)
IS  - 0378-4274 (Linking)
VI  - 275
DP  - 2017 Jun 5
TI  - Environmentally relevant dose of arsenic interferes in functions of human 
      monocytes derived dendritic cells.
PG  - 118-122
LID - S0378-4274(17)30173-X [pii]
LID - 10.1016/j.toxlet.2017.05.005 [doi]
AB  - Arsenic is a major environmental pollutant and highly hazardous toxin to human 
      health, which well established as carcinogen and immune deregulatory properties. 
      Dendritic cells (DCs) have a pivotal role in cell-mediated immunity for T-cell 
      activation and antigen presentation. In this study, T cell activation, some key 
      functional genes expression, cell stability and phagocytosis capacity of human 
      monocytes derived DCs (MDDCs) were analyzed after in vitro exposure to very low 
      dose of arsenic for 12 and 24h. Arsenic decreased continually phagocytosis 
      capacity of MDDCs. Furthermore, down-regulation of the cell-surface expression of 
      the co-stimulatory molecule CD40 after 24h post treatment with arsenic, confirmed 
      arsenic interferers in the phagocytosis process. Pro inflammatory cytokines, IL1beta 
      and TNFalpha were more expressed in arsenic-treated MDDCs while IL6 transiently was 
      down regulated. In general, our novel findings here strongly suggest that low 
      level of arsenic dysregulates four fundamental immune processes of DCs. 
      Mechanistically; this could explain the observed immunodeficiency activity of 
      Arsenic, and give direction for comprehension the pathogenesis of Arsenic-induced 
      diseases.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Bahari, Abbas
AU  - Bahari A
AD  - Biotechnology Group, Research Institute of Modern Biological Techniques, 
      University of Zanjan, Iran. Electronic address: Bahari@znu.ac.ir.
FAU - Salmani, Vahid
AU  - Salmani V
AD  - Biotechnology Group, Research Institute of Modern Biological Techniques, 
      University of Zanjan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170510
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Cytokines)
RN  - 0 (Environmental Pollutants)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Adolescent
MH  - Apoptosis/*drug effects
MH  - Arsenic/*toxicity
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Cytokines/genetics
MH  - Dendritic Cells/*drug effects/immunology/pathology
MH  - Dose-Response Relationship, Drug
MH  - Environmental Pollutants/*toxicity
MH  - Flow Cytometry
MH  - Humans
MH  - Leukocytes, Mononuclear/cytology
MH  - Male
MH  - Phagocytosis/*drug effects
MH  - Transcriptome/drug effects
MH  - Young Adult
OTO - NOTNLM
OT  - Arsenic
OT  - Monocytes derived dendritic cells
OT  - Phagocytosis
OT  - Proinflammatory cytokines
EDAT- 2017/05/14 06:00
MHDA- 2017/06/27 06:00
CRDT- 2017/05/14 06:00
PHST- 2017/02/27 00:00 [received]
PHST- 2017/04/26 00:00 [revised]
PHST- 2017/05/03 00:00 [accepted]
PHST- 2017/05/14 06:00 [pubmed]
PHST- 2017/06/27 06:00 [medline]
PHST- 2017/05/14 06:00 [entrez]
AID - S0378-4274(17)30173-X [pii]
AID - 10.1016/j.toxlet.2017.05.005 [doi]
PST - ppublish
SO  - Toxicol Lett. 2017 Jun 5;275:118-122. doi: 10.1016/j.toxlet.2017.05.005. Epub 
      2017 May 10.