PMID- 28500368
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20200330
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Print)
IS  - 0938-7994 (Linking)
VI  - 27
IP  - 11
DP  - 2017 Nov
TI  - Advanced myocardial tissue characterisation by a multi-component CMR protocol in 
      patients with rheumatoid arthritis.
PG  - 4639-4649
LID - 10.1007/s00330-017-4838-4 [doi]
AB  - OBJECTIVES: Rheumatoid arthritis (RA) patients are at increased risk of suffering 
      from adverse cardiovascular events. Cardiovascular magnetic resonance (CMR) 
      mapping techniques might be appropriate tools to complement late gadolinium 
      enhancement (LGE) for the assessment of myocardial involvement. This study aimed 
      to perform advanced myocardial tissue characterisation in RA patients by a 
      multicomponent CMR protocol. METHODS: 22 RA patients were prospectively enrolled 
      and underwent CMR, including LGE and T1/T2 mapping sequences; 20 volunteers 
      served as controls. RESULTS: Mean LV-EF was 66%; prevalence of LGE was 18%. RA 
      patients had increased native T1 (985 vs. 959 ms, p = 0.03), expanded 
      extracellular volume (ECV) (27 vs. 25%, p = 0.02) and higher T2 values (52 vs. 49 
      ms, p < 0.001) compared to controls irrespective of the presence of LGE. T2 
      mapping showed the highest prevalence of values beyond the 95% percentile of 
      controls. CONCLUSION: RA patients demonstrated higher T1, ECV and T2 values 
      compared to controls, with most significant differences for T2. Since these 
      results seem to be independent of the presence of LGE, advanced myocardial tissue 
      characterisation including CMR mapping techniques in addition to LGE-CMR might be 
      useful in the evaluation of myocardial involvement in RA patients. KEY POINTS: * 
      RA patients had higher T1, ECV and T2 values compared to controls. * Most 
      significant differences were observed for T2. * Our results seem to be 
      independent of the presence of LGE. * Mapping might be useful in the evaluation 
      of myocardial involvement in RA.
FAU - Greulich, Simon
AU  - Greulich S
AD  - Division of Cardiology, Robert-Bosch-Medical Center Stuttgart, Stuttgart, 
      Germany.
FAU - Mayr, Agnes
AU  - Mayr A
AD  - Division of Radiology, University Hospital Innsbruck, Anichstrasse 35, 6020, 
      Innsbruck, Austria. A.Mayr@i-med.ac.at.
FAU - Kitterer, Daniel
AU  - Kitterer D
AD  - Division of Nephrology, Department of Internal Medicine, Robert-Bosch-Medical 
      Center Stuttgart, Stuttgart, Germany.
FAU - Latus, Joerg
AU  - Latus J
AD  - Division of Nephrology, Department of Internal Medicine, Robert-Bosch-Medical 
      Center Stuttgart, Stuttgart, Germany.
FAU - Henes, Joerg
AU  - Henes J
AD  - Centre for Interdisciplinary Clinical Immunology, Rheumatology and 
      Auto-inflammatory Diseases and Department of Internal Medicine II (Oncology, 
      Haematology, Immunology, Rheumatology, Pulmology), University Hospital Tuebingen, 
      Tuebingen, Germany.
FAU - Vecchio, Francesco
AU  - Vecchio F
AD  - Division of Cardiology, Robert-Bosch-Medical Center Stuttgart, Stuttgart, 
      Germany.
AD  - Division of Cardiology, Universita degli Studi di Roma "Tor Vergata", Rome, 
      Italy.
FAU - Kaesemann, Philipp
AU  - Kaesemann P
AD  - Division of Cardiology, Robert-Bosch-Medical Center Stuttgart, Stuttgart, 
      Germany.
FAU - Patrascu, Alexandru
AU  - Patrascu A
AD  - Division of Cardiology, Robert-Bosch-Medical Center Stuttgart, Stuttgart, 
      Germany.
FAU - Greiser, Andreas
AU  - Greiser A
AD  - Siemens Healthcare GmbH, Erlangen, Germany.
FAU - Groeninger, Stefan
AU  - Groeninger S
AD  - Siemens Healthcare GmbH, Erlangen, Germany.
FAU - Romeo, Francesco
AU  - Romeo F
AD  - Division of Cardiology, Universita degli Studi di Roma "Tor Vergata", Rome, 
      Italy.
FAU - Braun, Niko
AU  - Braun N
AD  - Division of Nephrology, Department of Internal Medicine, Robert-Bosch-Medical 
      Center Stuttgart, Stuttgart, Germany.
FAU - Alscher, M Dominik
AU  - Alscher MD
AD  - Division of Nephrology, Department of Internal Medicine, Robert-Bosch-Medical 
      Center Stuttgart, Stuttgart, Germany.
FAU - Sechtem, Udo
AU  - Sechtem U
AD  - Division of Cardiology, Robert-Bosch-Medical Center Stuttgart, Stuttgart, 
      Germany.
FAU - Mahrholdt, Heiko
AU  - Mahrholdt H
AD  - Division of Cardiology, Robert-Bosch-Medical Center Stuttgart, Stuttgart, 
      Germany.
LA  - eng
GR  - KKF 13-2, KKF 15-5/Robert Bosch Stiftung/
PT  - Journal Article
DEP - 20170512
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/*complications/*diagnostic imaging/physiopathology
MH  - Cardiomyopathies/*diagnostic imaging/*etiology/physiopathology
MH  - Case-Control Studies
MH  - Contrast Media
MH  - Electrocardiography
MH  - Female
MH  - Gadolinium DTPA
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Magnetic Resonance Imaging, Cine/methods
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Stroke Volume/physiology
PMC - PMC5635099
OTO - NOTNLM
OT  - Cardiovascular magnetic resonance
OT  - Late gadolinium enhancement
OT  - Mapping
OT  - Myocardial involvement
OT  - Rheumatoid arthritis
COIS- A.G. and S.G. are employees of Siemens Healthcare GmbH. No non-financial 
      conflicts of interest exist for any of the authors.
EDAT- 2017/05/14 06:00
MHDA- 2018/06/05 06:00
PMCR- 2017/05/12
CRDT- 2017/05/14 06:00
PHST- 2016/11/04 00:00 [received]
PHST- 2017/04/03 00:00 [accepted]
PHST- 2017/03/21 00:00 [revised]
PHST- 2017/05/14 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
PHST- 2017/05/14 06:00 [entrez]
PHST- 2017/05/12 00:00 [pmc-release]
AID - 10.1007/s00330-017-4838-4 [pii]
AID - 4838 [pii]
AID - 10.1007/s00330-017-4838-4 [doi]
PST - ppublish
SO  - Eur Radiol. 2017 Nov;27(11):4639-4649. doi: 10.1007/s00330-017-4838-4. Epub 2017 
      May 12.