PMID- 28500647
OWN - NLM
STAT- MEDLINE
DCOM- 20171212
LR  - 20180816
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 57
IP  - 1
DP  - 2018 Jan
TI  - Serum brain-derived neurotrophic factor and interleukin-6 response to high-volume 
      mechanically demanding exercise.
PG  - E46-E51
LID - 10.1002/mus.25687 [doi]
AB  - INTRODUCTION: The aim of this study was to follow circulating brain-derived 
      neurotrophic factor (BDNF) and interleukin-6 (IL-6) levels in response to severe 
      muscle-damaging exercise. METHODS: Young healthy men (N = 10) performed a bout of 
      mechanically demanding stretch-shortening cycle exercise consisting of 200 drop 
      jumps. Voluntary and electrically induced knee extension torque, serum BDNF 
      levels, and IL-6 levels were measured before and for up to 7 days after exercise. 
      RESULTS: Muscle force decreased by up to 40% and did not recover by 24 hours 
      after exercise. Serum BDNF was decreased 1 hour and 24 hours after exercise, 
      whereas IL-6 increased immediately and 1 hour after but recovered to baseline by 
      24 hours after exercise. IL-6 and 100-Hz stimulation torque were correlated (r = 
      -0.64, P < 0.05) 24 hours after exercise. DISCUSSION: In response to acute, 
      severe muscle-damaging exercise, serum BDNF levels decrease, whereas IL-6 levels 
      increase and are associated with peripheral fatigue. Muscle Nerve 57: E46-E51, 
      2018.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Verbickas, Vaidas
AU  - Verbickas V
AD  - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, 
      Lithuania, Sporto 6, LT 44221, Kaunas, Lithuania.
FAU - Kamandulis, Sigitas
AU  - Kamandulis S
AD  - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, 
      Lithuania, Sporto 6, LT 44221, Kaunas, Lithuania.
FAU - Snieckus, Audrius
AU  - Snieckus A
AD  - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, 
      Lithuania, Sporto 6, LT 44221, Kaunas, Lithuania.
FAU - Venckunas, Tomas
AU  - Venckunas T
AD  - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, 
      Lithuania, Sporto 6, LT 44221, Kaunas, Lithuania.
FAU - Baranauskiene, Neringa
AU  - Baranauskiene N
AD  - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, 
      Lithuania, Sporto 6, LT 44221, Kaunas, Lithuania.
FAU - Brazaitis, Marius
AU  - Brazaitis M
AD  - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, 
      Lithuania, Sporto 6, LT 44221, Kaunas, Lithuania.
FAU - Satkunskiene, Danguole
AU  - Satkunskiene D
AD  - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, 
      Lithuania, Sporto 6, LT 44221, Kaunas, Lithuania.
FAU - Unikauskas, Alvydas
AU  - Unikauskas A
AD  - Department of Laboratory Medicine, Medical Academy, Lithuanian University of 
      Health Sciences, Mickeviciaus 9, Kaunas, Lithuania.
FAU - Skurvydas, Albertas
AU  - Skurvydas A
AD  - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, 
      Lithuania, Sporto 6, LT 44221, Kaunas, Lithuania.
LA  - eng
PT  - Journal Article
DEP - 20170530
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 2.7.3.2 (Creatine Kinase)
SB  - IM
MH  - Bicycling/physiology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Creatine Kinase/blood
MH  - Exercise/*physiology
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Knee/physiology
MH  - Male
MH  - Muscle Contraction/physiology
MH  - Muscle Fatigue/physiology
MH  - Muscle, Skeletal/physiology
MH  - Myalgia/physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - central motor fatigue
OT  - cytokines
OT  - muscle soreness
OT  - muscle torque
OT  - peripheral fatigue
OT  - stretch-shortening cycle exercise
EDAT- 2017/05/14 06:00
MHDA- 2017/12/13 06:00
CRDT- 2017/05/14 06:00
PHST- 2016/10/31 00:00 [received]
PHST- 2017/04/21 00:00 [revised]
PHST- 2017/05/07 00:00 [accepted]
PHST- 2017/05/14 06:00 [pubmed]
PHST- 2017/12/13 06:00 [medline]
PHST- 2017/05/14 06:00 [entrez]
AID - 10.1002/mus.25687 [doi]
PST - ppublish
SO  - Muscle Nerve. 2018 Jan;57(1):E46-E51. doi: 10.1002/mus.25687. Epub 2017 May 30.