PMID- 28501167
OWN - NLM
STAT- MEDLINE
DCOM- 20180830
LR  - 20191210
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 170
DP  - 2017 Aug 1
TI  - Polyoxometalate incorporated polymer monolith microextraction for highly 
      selective extraction of antidepressants in undiluted urine.
PG  - 252-259
LID - S0039-9140(17)30447-2 [pii]
LID - 10.1016/j.talanta.2017.04.020 [doi]
AB  - In this work, a polyoxometalate (POM) incorporated polymer monolith 
      microextraction (PMME) was successfully proposed and employed in the selective 
      extraction of basic antidepressants in undiluted urine sample. This hybrid 
      monolith exhibited strong cation-exchange interaction (SCX) with positively 
      charged antidepressants when pH was 3.0, because of the multiple ionizable 
      moieties on polyanionic POM. As such, antidepressants in complex sample matrices 
      were efficiently extracted by the monolith, and the matrix effect was 
      significantly reduced. In addition, due to the high amount of anionic POM, the 
      monolith exhibited remarkable extraction capacities for target antidepressants 
      ranging from 4.7 to 5.8mg/g. Further, the POM incorporated PMME was coupled with 
      high-performance liquid chromatography-ultraviolet (HPLC-UV). Thus, 
      antidepressants in undiluted urine sample was efficiently extracted under 
      optimized extraction conditions online. The limits of detection (LODs) for the 
      target antidepressants ranged from 0.7 to 1.4ng/mL, and the linear range was 
      5-1000ng/mL with determination coefficients (R(2)) higher than 0.9960. The 
      recoveries ranged from 86.8% to 104.0% with relative standard deviations (RSDs) 
      of 0.4-10.1%. The proposed procedure was successfully applied to determine 
      antidepressant in human urine. Taken together, the developed method presented a 
      new strategy for the analysis of basic drugs in undiluted urine sample, which 
      could be used for monitoring medicines in pharmacokinetic analysis.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Cai, Jiao
AU  - Cai J
AD  - Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of 
      Education), Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
FAU - Zhu, Gang-Tian
AU  - Zhu GT
AD  - Key Laboratory of Tectonics and Petroleum Resources (Ministry of Education), 
      China University of Geosciences, Wuhan 430075, PR China.
FAU - He, Xiao-Mei
AU  - He XM
AD  - Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of 
      Education), Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
FAU - Zhang, Zheng
AU  - Zhang Z
AD  - Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of 
      Education), Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
FAU - Wang, Ren-Qi
AU  - Wang RQ
AD  - Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of 
      Education), Department of Chemistry, Wuhan University, Wuhan 430072, PR China; 
      College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 
      730000, PR China.
FAU - Feng, Yu-Qi
AU  - Feng YQ
AD  - Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of 
      Education), Department of Chemistry, Wuhan University, Wuhan 430072, PR China. 
      Electronic address: yqfeng@whu.edu.cn.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20170412
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Antidepressive Agents)
RN  - 0 (Tungsten Compounds)
RN  - 0 (polyoxometalate I)
SB  - IM
MH  - Adsorption
MH  - Antidepressive Agents/isolation & purification/*urine
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Humans
MH  - Limit of Detection
MH  - Solid Phase Microextraction/*methods
MH  - Tungsten Compounds/*chemistry
OTO - NOTNLM
OT  - Antidepressants
OT  - Polymer monolith microextraction
OT  - Polyoxometalates
OT  - Strong cation-exchange interaction
OT  - Urine sample
EDAT- 2017/05/16 06:00
MHDA- 2018/08/31 06:00
CRDT- 2017/05/15 06:00
PHST- 2017/01/05 00:00 [received]
PHST- 2017/04/07 00:00 [revised]
PHST- 2017/04/09 00:00 [accepted]
PHST- 2017/05/15 06:00 [entrez]
PHST- 2017/05/16 06:00 [pubmed]
PHST- 2018/08/31 06:00 [medline]
AID - S0039-9140(17)30447-2 [pii]
AID - 10.1016/j.talanta.2017.04.020 [doi]
PST - ppublish
SO  - Talanta. 2017 Aug 1;170:252-259. doi: 10.1016/j.talanta.2017.04.020. Epub 2017 
      Apr 12.