PMID- 28501181
OWN - NLM
STAT- MEDLINE
DCOM- 20180830
LR  - 20180830
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 170
DP  - 2017 Aug 1
TI  - A voltammetry sensor platform for baicalein and baicalin simultaneous detection 
      in vivo based on Ta(2)O(5)-Nb(2)O(5)@CTS composite.
PG  - 358-368
LID - S0039-9140(17)30444-7 [pii]
LID - 10.1016/j.talanta.2017.04.022 [doi]
AB  - Baicalein and baicalin are the major flavonoids found in Scutellariae Radix, an 
      essential herb which has had a presence in traditional Chinese medicine (TCMs) 
      for more than two thousands of years. Owing to their similar characteristics and 
      physiochemical properties, sensitive, it is a great challenge to detect both of 
      them simultaneously. In this work, a novel, facile and sensitive electrochemical 
      method was proposed based on tantalum oxide (Ta(2)O(5)), niobium oxide 
      (Nb(2)O(5)) particles and antiseptic chitosan modified carbon paste electrode 
      (Ta(2)O(5)-Nb(2)O(5)@CTS-CPE). Scanning electron microscope (SEM), X-ray 
      diffraction spectroscopy (XRD), Fourier transform infrared spectroscopy (FTIR), 
      cyclic voltammetry (CV) and electrochemical impedance spectrum (EIS) were used to 
      characterize the properties and investigate the electrochemical response of the 
      sensor. The electrochemical behaviors and redox mechanisms of two analytes were 
      investigated at the target electrode. Under the optimum conditions, the highly 
      sensitive and simultaneous determination of baicalein and baicalin was 
      successfully achieved with a linear response range of 0.08-8.0muM for both of 
      them. The obtained detection limits for baicalein and baicalin were of 0.05 and 
      0.03muM (S/N=3), respectively. Furthermore, the proposed sensor displayed high 
      sensitivity, excellent stability and satisfactory results in Scutellariae Radix 
      samples analysis and hydrolysis process analysis of baicalin in vivo.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Xie, Zhengkun
AU  - Xie Z
AD  - College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 
      450001, PR China.
FAU - Lu, Wang
AU  - Lu W
AD  - College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 
      450001, PR China; Department of Environmental Engineering and Chemistry, Luoyang 
      Institute of Science and Technology, Luoyang 471023, PR China.
FAU - Yang, Lingxi
AU  - Yang L
AD  - Zhumadian Hydrology and Water Resource Survey Bureau of Henan Province, Zhumadian 
      463600, PR China.
FAU - Li, Gaiping
AU  - Li G
AD  - College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 
      450001, PR China. Electronic address: lgpingzy@zzu.edu.cn.
FAU - Ye, Baoxian
AU  - Ye B
AD  - College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 
      450001, PR China. Electronic address: yebx@zzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170414
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Flavanones)
RN  - 0 (Flavonoids)
RN  - 0 (Oxides)
RN  - 05175J654G (Niobium)
RN  - 347Q89U4M5 (baicalin)
RN  - 49QAH60606 (baicalein)
RN  - 6424HBN274 (Tantalum)
RN  - 7440-44-0 (Carbon)
RN  - 9012-76-4 (Chitosan)
RN  - K9343U17IN (niobium pentoxide)
RN  - OEZ64Z53M4 (tantalum oxide)
SB  - IM
MH  - Carbon/chemistry
MH  - Chitosan/chemistry
MH  - Drugs, Chinese Herbal/*chemistry
MH  - Electrochemical Techniques/methods
MH  - Electrodes
MH  - Flavanones/*analysis
MH  - Flavonoids/*analysis
MH  - Niobium/*chemistry
MH  - Oxides/*chemistry
MH  - Scutellaria baicalensis/*chemistry
MH  - Tantalum/*chemistry
OTO - NOTNLM
OT  - Baicalein
OT  - Baicalin
OT  - Bimetallic oxide particles
OT  - Chitosan
OT  - Escherichia coli
OT  - Voltammetry sensor
EDAT- 2017/05/16 06:00
MHDA- 2018/08/31 06:00
CRDT- 2017/05/15 06:00
PHST- 2017/02/21 00:00 [received]
PHST- 2017/03/29 00:00 [revised]
PHST- 2017/04/09 00:00 [accepted]
PHST- 2017/05/15 06:00 [entrez]
PHST- 2017/05/16 06:00 [pubmed]
PHST- 2018/08/31 06:00 [medline]
AID - S0039-9140(17)30444-7 [pii]
AID - 10.1016/j.talanta.2017.04.022 [doi]
PST - ppublish
SO  - Talanta. 2017 Aug 1;170:358-368. doi: 10.1016/j.talanta.2017.04.022. Epub 2017 
      Apr 14.