PMID- 28501519
OWN - NLM
STAT- MEDLINE
DCOM- 20180529
LR  - 20180529
IS  - 1444-2892 (Electronic)
IS  - 1443-9506 (Linking)
VI  - 26
IP  - 11
DP  - 2017 Nov
TI  - The Utility of Cardiac Magnetic Resonance Imaging in the Diagnosis of Cardiac 
      Sarcoidosis.
PG  - 1191-1199
LID - S1443-9506(17)30280-9 [pii]
LID - 10.1016/j.hlc.2017.02.021 [doi]
AB  - BACKGROUND: Autopsy reports suggest that cardiac sarcoidosis occurs in 20 to 25% 
      of patients with pulmonary sarcoidosis, yet the clinical ante-mortem diagnosis is 
      made in only 5% of cases. Current diagnostic algorithms are complex and lack 
      sensitivity. Cardiac Magnetic Resonance imaging (CMR) provides an opportunity to 
      detect myocardial involvement in sarcoidosis. The aim of this study is to 
      determine the prevalence and clinical significance of late gadolinium enhancement 
      (LGE) on CMR in patients with sarcoidosis. METHODS: Consecutive patients with 
      biopsy-proven sarcoidosis undergoing CMR were retrospectively evaluated for 
      cardiac sarcoidosis. Medical records were correlated with CMR. RESULTS: Forty-six 
      patients were evaluated. Late gadolinium enhancement was present in 22%, 
      indicating myocardial involvement, and 70% had corresponding hyper-intense T2 
      signal indicating active inflammation. Late gadolinium enhancement was 18%+/-9.7% 
      of overall left ventricular (LV) mass and most commonly located in the basal to 
      mid septum. There was no association between LGE and cardiovascular symptoms or 
      pulmonary stage. Eighty per cent of patients with LGE did not fulfill 
      conventional diagnostic criteria for cardiac sarcoidosis. However, LGE was 
      associated with clinically significant arrhythmia (p<0.01) and a lower LVEF 
      (p=0.04). CONCLUSIONS: Using CMR, we identified a higher prevalence of cardiac 
      sarcoidosis than previously reported clinical studies, a prevalence which is more 
      consistent with autopsy data. The presence of LGE was highly correlated with 
      clinically significant arrhythmias and lower LVEF.
CI  - Copyright (c) 2017 Australian and New Zealand Society of Cardiac and Thoracic 
      Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). 
      All rights reserved.
FAU - Stanton, Kelly M
AU  - Stanton KM
AD  - Cardiology Department, Royal Prince Alfred Hospital, Sydney, NSW, Australia; The 
      Heart Research Institute, Sydney, NSW, Australia; Sydney Medical School, the 
      University of Sydney, Sydney, NSW, Australia. Electronic address: 
      kelly.m.stanton@gmail.com.
FAU - Ganigara, Madhusudan
AU  - Ganigara M
AD  - Department of Cardiology, Faculty of Pediatrics, the University of Sydney, 
      Sydney, NSW, Australia; The Children's Hospital at Westmead, Sydney, NSW, 
      Australia.
FAU - Corte, Peter
AU  - Corte P
AD  - Respiratory Department, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
FAU - Celermajer, David S
AU  - Celermajer DS
AD  - Cardiology Department, Royal Prince Alfred Hospital, Sydney, NSW, Australia; 
      Sydney Medical School, the University of Sydney, Sydney, NSW, Australia.
FAU - McGuire, Mark A
AU  - McGuire MA
AD  - Cardiology Department, Royal Prince Alfred Hospital, Sydney, NSW, Australia; 
      Sydney Medical School, the University of Sydney, Sydney, NSW, Australia.
FAU - Torzillo, Paul J
AU  - Torzillo PJ
AD  - Sydney Medical School, the University of Sydney, Sydney, NSW, Australia; 
      Respiratory Department, Royal Prince Alfred Hospital, Sydney, NSW, Australia; The 
      Intensive Care Service, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, 
      Australia.
FAU - Corte, Tamera J
AU  - Corte TJ
AD  - Sydney Medical School, the University of Sydney, Sydney, NSW, Australia; 
      Respiratory Department, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
FAU - Puranik, Rajesh
AU  - Puranik R
AD  - Cardiology Department, Royal Prince Alfred Hospital, Sydney, NSW, Australia; 
      Sydney Medical School, the University of Sydney, Sydney, NSW, Australia.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20170404
PL  - Australia
TA  - Heart Lung Circ
JT  - Heart, lung & circulation
JID - 100963739
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Algorithms
MH  - Biopsy
MH  - Cardiomyopathies/*diagnosis/pathology
MH  - Gadolinium/*administration & dosage
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sarcoidosis/*diagnostic imaging/pathology
OTO - NOTNLM
OT  - Arrhythmia
OT  - Cardiac magnetic resonance imaging
OT  - Cardiac sarcoidosis
OT  - Late gadolinium enhancement
EDAT- 2017/05/16 06:00
MHDA- 2018/05/31 06:00
CRDT- 2017/05/15 06:00
PHST- 2016/05/28 00:00 [received]
PHST- 2016/08/20 00:00 [revised]
PHST- 2017/02/18 00:00 [accepted]
PHST- 2017/05/16 06:00 [pubmed]
PHST- 2018/05/31 06:00 [medline]
PHST- 2017/05/15 06:00 [entrez]
AID - S1443-9506(17)30280-9 [pii]
AID - 10.1016/j.hlc.2017.02.021 [doi]
PST - ppublish
SO  - Heart Lung Circ. 2017 Nov;26(11):1191-1199. doi: 10.1016/j.hlc.2017.02.021. Epub 
      2017 Apr 4.