PMID- 28501772
OWN - NLM
STAT- MEDLINE
DCOM- 20180319
LR  - 20180319
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 91
DP  - 2017 Jul
TI  - Hyperoside protects against chronic mild stress-induced learning and memory 
      deficits.
PG  - 831-840
LID - S0753-3322(17)30743-6 [pii]
LID - 10.1016/j.biopha.2017.05.019 [doi]
AB  - Hyperoside (quercetin-3-O-b-d-galactosidepyranose) is a plant-derived flavonoid 
      mainly found in fruits, fruit juices (most notably flavanols, flavanones, and 
      anthocyanins) and Chinese traditional medicines. It has been applied to relieve 
      pain and improve cardiovascular functions in clinic. However, the effects of 
      hyperoside on cognitive impairment induced by chronic stress and the underlying 
      molecular mechanisms remain unclear. In the current study, we used chronic mild 
      stress (CMS) rats to investigate the effects of hyperoside on learning and memory 
      and further explore the possible mechanisms. Our results demonstrated that 
      hyperoside reduced the escape latency and the swimming distance of CMS rats in 
      Morris water maze test and reversed depressive symptoms in forced swim test (FST) 
      and sucrose preference test. In addition, hyperoside increased the expression of 
      brain-derived neurotrophic factor (BDNF) in hippocampus of CMS rats without 
      influencing the corticosterone (CORT) level in blood plasma. Furthermore, K252a, 
      an inhibitor of the BDNF receptor TrkB, prevented the protective effects of 
      hyperoside on learning and memory in CMS rats. Taken together, these results 
      indicate that hyperoside reverses the cognitive impairment induced by CMS, which 
      is associated with the regulation of BDNF signaling pathway.
CI  - Copyright (c) 2017 Elsevier Masson SAS. All rights reserved.
FAU - Gong, Yeli
AU  - Gong Y
AD  - Department of Immunology, Medical College, Jianghan University, Wuhan 430056, 
      China.
FAU - Yang, Youhua
AU  - Yang Y
AD  - Department of Physiology, Medical College, Jianghan University, Wuhan 430056, 
      China.
FAU - Chen, Xiaoqing
AU  - Chen X
AD  - Experimental Centre, Medical College, Jianghan University, Wuhan 430056, China.
FAU - Yang, Min
AU  - Yang M
AD  - Department of Physiology, Medical College, Jianghan University, Wuhan 430056, 
      China.
FAU - Huang, Dan
AU  - Huang D
AD  - Department of Physiology, Medical College, Jianghan University, Wuhan 430056, 
      China.
FAU - Yang, Rong
AU  - Yang R
AD  - Department of Physiology, Medical College, Jianghan University, Wuhan 430056, 
      China.
FAU - Zhou, Lianying
AU  - Zhou L
AD  - Department of Physiology, Medical College, Jianghan University, Wuhan 430056, 
      China.
FAU - Li, Changlei
AU  - Li C
AD  - Experimental Centre, Medical College, Jianghan University, Wuhan 430056, China.
FAU - Xiong, Qiuju
AU  - Xiong Q
AD  - Department of Pain Management, Wuhan Pu-Ai Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan 430033, China.
FAU - Xiong, Zhe
AU  - Xiong Z
AD  - Department of Physiology, Medical College, Jianghan University, Wuhan 430056, 
      China. Electronic address: Panda0211089@163.com.
LA  - eng
PT  - Journal Article
DEP - 20170511
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbazoles)
RN  - 0 (Indole Alkaloids)
RN  - 0 (Neuroprotective Agents)
RN  - 8O1CR18L82 (hyperoside)
RN  - 97161-97-2 (staurosporine aglycone)
RN  - 9IKM0I5T1E (Quercetin)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Carbazoles/pharmacology
MH  - Chronic Disease
MH  - Cognition/drug effects
MH  - Corticosterone/blood
MH  - Depression/blood/complications/drug therapy/physiopathology
MH  - Hippocampus/metabolism
MH  - Indole Alkaloids/pharmacology
MH  - *Learning/drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/blood/*drug therapy/*etiology/physiopathology
MH  - Neuroprotective Agents/chemistry/pharmacology/*therapeutic use
MH  - Quercetin/*analogs & derivatives/chemistry/pharmacology/therapeutic use
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/metabolism
MH  - Stress, Psychological/blood/*complications/physiopathology
OTO - NOTNLM
OT  - BDNF
OT  - Chronic mild stress
OT  - Hyperoside
OT  - Learning and memory
EDAT- 2017/05/16 06:00
MHDA- 2018/03/20 06:00
CRDT- 2017/05/15 06:00
PHST- 2017/02/17 00:00 [received]
PHST- 2017/05/01 00:00 [revised]
PHST- 2017/05/04 00:00 [accepted]
PHST- 2017/05/16 06:00 [pubmed]
PHST- 2018/03/20 06:00 [medline]
PHST- 2017/05/15 06:00 [entrez]
AID - S0753-3322(17)30743-6 [pii]
AID - 10.1016/j.biopha.2017.05.019 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2017 Jul;91:831-840. doi: 10.1016/j.biopha.2017.05.019. Epub 
      2017 May 11.