PMID- 28502041 OWN - NLM STAT- MEDLINE DCOM- 20190204 LR - 20190215 IS - 1559-1182 (Electronic) IS - 0893-7648 (Linking) VI - 55 IP - 4 DP - 2018 Apr TI - Glucose Can Epigenetically Alter the Gene Expression of Neurotrophic Factors in the Murine Brain Cells. PG - 3408-3425 LID - 10.1007/s12035-017-0578-3 [doi] AB - Glucose is believed to improve the memory in both human and mice, but the detailed insights were mostly elusive. In this study, we focused on two major neurotrophic factors, brain-derived neurotrophic factor (BDNF) and fibroblast growth factor 1 (FGF1), which are believed to be associated with the memory enhancement and assessed their expressional regulation among the murine neuronal and glial cells. Our findings showed that the glucose administration increased phosphorylated Akt, phosphorylated CREB, exon 1- and exon 4-specific BDNF transcripts, and FGF1 transcripts that are associated with the epigenetic changes expected to open the chromatin and a reduction in histone deacetylase 2 (HDAC2) in neurons and astrocytes of the murine hippocampus. The glucose administration enhanced the long-term potentiation and the number of dendritic spines in the CA1 and CA3 subfields of hippocampus. The intrahippocampal injection of short hairpin RNA against TrkB canceled the glucose-mediated memory enhancement. Like the glucose, we also report that the HDAC inhibitor can enhance the memory through the BDNF-TrkB pathway but it targeted different brain cell populations to enhance the BDNF and FGF1 transcripts. In addition, the soluble FGF1 treatments significantly increased the BDNF expression in astrocytes and neurons, suggesting that the glucose-mediated induction of the neurotrophic factors could contribute to the memory. Our study provides the valuable insights, explaining the distinctive neuronal and glial cell regulation of the neurotrophic factors by glucose and HDAC inhibitor, which could likely explain how our brain cells can control the release of neurotrophic factors. FAU - Hossain, Md Shamim AU - Hossain MS AD - Department of Neuroinflammation and Brain Fatigue Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. shamim@physiol.med.kyushu-u.ac.jp. FAU - Oomura, Yutaka AU - Oomura Y AD - Department of Neuroinflammation and Brain Fatigue Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. FAU - Katafuchi, Toshihiko AU - Katafuchi T AD - Department of Neuroinflammation and Brain Fatigue Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. LA - eng GR - 16K19007/Japan Society for the Promotion of Science/ GR - 22590225/Japan Society for the Promotion of Science/ PT - Journal Article DEP - 20170513 PL - United States TA - Mol Neurobiol JT - Molecular neurobiology JID - 8900963 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Cyclic AMP Response Element-Binding Protein) RN - 0 (Histone Deacetylase Inhibitors) RN - 0 (Histones) RN - 104781-85-3 (Fibroblast Growth Factor 1) RN - 58IFB293JI (Vorinostat) RN - EC 2.7.10.1 (Receptor, trkB) RN - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt) RN - IY9XDZ35W2 (Glucose) SB - IM MH - Acetylation MH - Animals MH - Brain/*cytology MH - Brain-Derived Neurotrophic Factor/*genetics/metabolism MH - Cyclic AMP Response Element-Binding Protein/metabolism MH - Dendritic Spines/drug effects/metabolism MH - Epigenesis, Genetic/*drug effects MH - Feedback, Physiological MH - Fibroblast Growth Factor 1/*genetics/metabolism MH - Glucose/*pharmacology MH - Hippocampus/cytology MH - Histone Deacetylase Inhibitors/pharmacology MH - Histones/metabolism MH - Long-Term Potentiation/drug effects MH - Memory/drug effects MH - Mice, Inbred C57BL MH - Phosphorylation/drug effects MH - Promoter Regions, Genetic/genetics MH - Proto-Oncogene Proteins c-akt/metabolism MH - Receptor, trkB/metabolism MH - Vorinostat/pharmacology OTO - NOTNLM OT - BDNF OT - FGF1 OT - Glucose OT - Memory OT - SAHA OT - TrkB EDAT- 2017/05/16 06:00 MHDA- 2019/02/05 06:00 CRDT- 2017/05/15 06:00 PHST- 2016/12/09 00:00 [received] PHST- 2017/04/26 00:00 [accepted] PHST- 2017/05/16 06:00 [pubmed] PHST- 2019/02/05 06:00 [medline] PHST- 2017/05/15 06:00 [entrez] AID - 10.1007/s12035-017-0578-3 [pii] AID - 10.1007/s12035-017-0578-3 [doi] PST - ppublish SO - Mol Neurobiol. 2018 Apr;55(4):3408-3425. doi: 10.1007/s12035-017-0578-3. Epub 2017 May 13.