PMID- 28502193
OWN - NLM
STAT- MEDLINE
DCOM- 20171010
LR  - 20171010
IS  - 1744-4160 (Electronic)
IS  - 1381-3455 (Linking)
VI  - 123
IP  - 5
DP  - 2017 Dec
TI  - Early-onset obesity and food restriction alter hepatocyte metabolism in adult 
      Wistar rats.
PG  - 297-305
LID - 10.1080/13813455.2017.1326942 [doi]
AB  - CONTEXT: Caloric restriction (CR) is suggested for overweight control. OBJECTIVE: 
      Systemic and liver glucose metabolism in the reduced-litter (RL) rat model under 
      30% CR was investigated. MATERIALS AND METHODS: Newborn litters were organised in 
      control (G9); RL with free diet (G3L); and RL with CR (G3R). Assessments were 
      made at the age of 90 d. RESULTS: Higher liver glycogen content and changes in 
      systemic glucose handling were found in the RL groups. Hepatocyte glucose 
      metabolism was similar in groups G9 and G3L, but basal glucose production and 
      glycogenolysis were higher, while gluconeogenesis and basal glycolysis were lower 
      in the G3R. Urea production was lower in the RL groups. DISCUSSION: The altered 
      glucose handling of the RL adult rats was not reversed by moderate (30%) CR. 
      Hepatocyte glucose and nitrogen metabolism were changed by both early overfeeding 
      and current feeding conditions. CONCLUSIONS: RL and CR alter systemic and liver 
      glucose metabolism.
FAU - Branquinho, Nayra Thais D
AU  - Branquinho NTD
AD  - a Program of Graduate Studies in Biological Sciences , State University of 
      Maringa , Maringa, Brazil.
FAU - Cruz, Gabriel Henrique P
AU  - Cruz GHP
AD  - b Department of Biological Sciences , State University of Maringa , Maringa, 
      Brazil.
FAU - Borrasca, Cristian L
AU  - Borrasca CL
AD  - b Department of Biological Sciences , State University of Maringa , Maringa, 
      Brazil.
FAU - Alves, Lucas de Paula S
AU  - Alves LPS
AD  - c Department of Medicine , State University of Maringa , Maringa, Brazil.
FAU - de Godoy Gomes, Celia Regina
AU  - de Godoy Gomes CR
AD  - d Department of Morphological Sciences , State University of Maringa , Maringa, 
      Brazil.
FAU - Ferreira de Godoi, Vilma Aparecida
AU  - Ferreira de Godoi VA
AD  - e Department of Physiological Sciences , State University of Maringa , Maringa, 
      Brazil.
FAU - Pedrosa, Maria Montserrat Diaz
AU  - Pedrosa MMD
AUID- ORCID: 0000-0002-0596-3557
AD  - e Department of Physiological Sciences , State University of Maringa , Maringa, 
      Brazil.
LA  - eng
PT  - Journal Article
DEP - 20170513
PL  - England
TA  - Arch Physiol Biochem
JT  - Archives of physiology and biochemistry
JID - 9510153
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Blood Glucose/metabolism
MH  - *Caloric Restriction
MH  - Female
MH  - Hepatocytes/*metabolism
MH  - Lactation
MH  - Litter Size
MH  - Male
MH  - Obesity/blood/*metabolism/*pathology
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Caloric restriction
OT  - glucose
OT  - liver metabolism
OT  - obesity
OT  - reduced litter
EDAT- 2017/05/16 06:00
MHDA- 2017/10/11 06:00
CRDT- 2017/05/16 06:00
PHST- 2017/05/16 06:00 [pubmed]
PHST- 2017/10/11 06:00 [medline]
PHST- 2017/05/16 06:00 [entrez]
AID - 10.1080/13813455.2017.1326942 [doi]
PST - ppublish
SO  - Arch Physiol Biochem. 2017 Dec;123(5):297-305. doi: 
      10.1080/13813455.2017.1326942. Epub 2017 May 13.