PMID- 28502652
OWN - NLM
STAT- MEDLINE
DCOM- 20180131
LR  - 20180426
IS  - 1879-0089 (Electronic)
IS  - 0145-305X (Linking)
VI  - 76
DP  - 2017 Nov
TI  - Comparative and evolutionary analysis of an adapter molecule MyD88 in 
      invertebrate metazoans.
PG  - 18-24
LID - S0145-305X(17)30200-8 [pii]
LID - 10.1016/j.dci.2017.05.007 [doi]
AB  - The myeloid differentiation factor 88 (MyD88) is an essential adapter in 
      Toll-like receptor (TLR) signalling pathways, with TLR the first 
      pattern-recognition receptor (PRR) that was discovered in Drosophila. In the 
      present study, a MyD88 gene was identified and characterized from a commercially 
      important shellfish, Scapharca subcrenata, including a DEATH domain and TIR 
      domain conserved within other molluscs. Furthermore, comparative genomic evidence 
      revealed that MyD88 was of different lengths and contained quantitative exon and 
      intron regions, which might be involved in specific mechanisms. To further 
      explore the phylogenetic relationships of invertebrate metazoan MyD88, we applied 
      MrBayes and PhyML software to construct phylogenetic trees using Bayesian and 
      maximum likelihood approaches, respectively, which suggested that the MyD88 of 
      Arthropoda was closely related to lower invertebrates, in contrast to 
      morphological taxonomy. Finally, we investigated the evolutionary patterns and 
      location of positive selection sites (PSSs) in the MyD88 gene from Arthropoda, 
      Mollusca and Insecta using PAML software with the maximum likelihood method. The 
      data showed that positive selection sites were detected in these groups, and 
      partial sites were located in the TIR domain but were not found in the DEATH 
      domain. To summarize, in this study, we report on the diversification of MyD88 in 
      invertebrate metazoans, the specific evolutionary position of Arthropoda MyD88, 
      and the positive selection pressures on MyD88 of Arthropoda, Mollusca and 
      Insecta. These results are a valuable contribution to understand and clarify the 
      evolutionary pattern of TLR/MyD88 signalling pathways in invertebrate and 
      vertebrate taxa.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Ren, Yipeng
AU  - Ren Y
AD  - Institute of Entomology, College of Life Sciences, Nankai University, Weijin Road 
      No. 94, Tianjin, 300071, PR China.
FAU - Xue, Junli
AU  - Xue J
AD  - Institute of Entomology, College of Life Sciences, Nankai University, Weijin Road 
      No. 94, Tianjin, 300071, PR China.
FAU - Yang, Huanhuan
AU  - Yang H
AD  - Institute of Entomology, College of Life Sciences, Nankai University, Weijin Road 
      No. 94, Tianjin, 300071, PR China.
FAU - Pan, Baoping
AU  - Pan B
AD  - Tianjin Key Laboratory of Animal and Plant Resistance, School of Life Sciences, 
      Tianjin Normal University, Tianjin, 300387, PR China.
FAU - Bu, Wenjun
AU  - Bu W
AD  - Institute of Entomology, College of Life Sciences, Nankai University, Weijin Road 
      No. 94, Tianjin, 300071, PR China. Electronic address: wenjunbu@nankai.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170511
PL  - United States
TA  - Dev Comp Immunol
JT  - Developmental and comparative immunology
JID - 7708205
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Bayes Theorem
MH  - Biological Evolution
MH  - Invertebrates/*genetics
MH  - Likelihood Functions
MH  - Myeloid Differentiation Factor 88/*genetics
MH  - Phylogeny
MH  - Signal Transduction/genetics
MH  - Toll-Like Receptors/genetics
OTO - NOTNLM
OT  - Evolutionary patterns
OT  - Invertebrate metazoans
OT  - Myeloid differentiation factor 88
OT  - Positive selection pressures
EDAT- 2017/05/16 06:00
MHDA- 2018/02/01 06:00
CRDT- 2017/05/16 06:00
PHST- 2017/04/10 00:00 [received]
PHST- 2017/05/10 00:00 [revised]
PHST- 2017/05/10 00:00 [accepted]
PHST- 2017/05/16 06:00 [pubmed]
PHST- 2018/02/01 06:00 [medline]
PHST- 2017/05/16 06:00 [entrez]
AID - S0145-305X(17)30200-8 [pii]
AID - 10.1016/j.dci.2017.05.007 [doi]
PST - ppublish
SO  - Dev Comp Immunol. 2017 Nov;76:18-24. doi: 10.1016/j.dci.2017.05.007. Epub 2017 
      May 11.