PMID- 28503322
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2058-6124 (Print)
IS  - 2058-6124 (Electronic)
IS  - 2058-6124 (Linking)
VI  - 3
DP  - 2017
TI  - Changes in oxidized LDL during a half marathon in athletes with spinal cord 
      injuries.
PG  - 17015
LID - 10.1038/scsandc.2017.15 [doi]
AB  - INTRODUCTION: We reported previously that exercise significantly increases plasma 
      adrenaline and oxidized low-density lipoprotein (oxLDL) in healthy subjects but 
      not in persons with spinal cord injury (SCI). Since oxLDL and adrenaline levels 
      are associated with oxidant/antioxidant balance, and exercise training elicits 
      production of reactive oxygen species, we elucidated the effects of exercise on 
      adrenaline, oxidant/antioxidant balance and oxLDL in individuals with SCI. CASE 
      PRESENTATION: Eight subjects with cervical spinal cord injury (CSCI) and nine 
      subjects with lower lesion of SCI (lower SCI (LSCI)) participated in a wheelchair 
      half marathon race, and blood samples were collected before (pre), immediately 
      after (post) and 1 h after the race (post 1 h). The blood samples were used to 
      determine adrenaline, derivatives of reactive oxygen metabolites (d-ROMs) and 
      biological antioxidant potential (BAP), both as markers for oxidant/antioxidant 
      balance. DISCUSSION: Pre-serum oxLDL levels were 147.2+/-8.1 and 97.0+/-10.4 U l(-1) 
      (mean+/-s.e.m.) in LCSI and CSCI subjects, respectively, and remained stable 
      throughout the study. Adrenaline levels were higher in LSCI athletes than in CSCI 
      athletes, especially post half marathon. Serum d-ROMs level did not change 
      between pre and post in both groups. The mean BAP was significantly higher in 
      LSCI than in CSCI subjects (2574+/-94.6 vs 2118+/-94.6 mumol l(-1)) at post, whereas 
      the oxidative stress index (d-ROMs/BAP) was similar in the two groups throughout 
      the study. In conclusion, exercise did not increase the d-ROMs or d-ROMs/BAP 
      ratio in CSCI and LSCI subjects. The lack of increase in the plasma oxLDL level 
      in SCI subjects was not due to the lack of response of adrenaline to exercise.
FAU - Mitsui, Toshihito
AU  - Mitsui T
AD  - Department of Rehabilitation Medicine and Sports Medical Center, Wakayama Medical 
      University School of Medicine, Wakayama City, Japan.
AD  - Faculty of Sports Science, Nihon Fukushi University, Mihama, Aichi, Japan.
FAU - Ito, Tomoyuki
AU  - Ito T
AD  - Department of Rehabilitation Medicine and Sports Medical Center, Wakayama Medical 
      University School of Medicine, Wakayama City, Japan.
FAU - Sasaki, Yusuke
AU  - Sasaki Y
AD  - Department of Rehabilitation Medicine and Sports Medical Center, Wakayama Medical 
      University School of Medicine, Wakayama City, Japan.
FAU - Kawasaki, Takashi
AU  - Kawasaki T
AD  - Department of Rehabilitation Medicine and Sports Medical Center, Wakayama Medical 
      University School of Medicine, Wakayama City, Japan.
FAU - Nakamura, Takeshi
AU  - Nakamura T
AD  - Department of Rehabilitation Medicine and Sports Medical Center, Wakayama Medical 
      University School of Medicine, Wakayama City, Japan.
FAU - Nishimura, Yukihide
AU  - Nishimura Y
AD  - Department of Rehabilitation Medicine and Sports Medical Center, Wakayama Medical 
      University School of Medicine, Wakayama City, Japan.
FAU - Ibusuki, Tatsuru
AU  - Ibusuki T
AD  - Department of Rehabilitation Medicine and Sports Medical Center, Wakayama Medical 
      University School of Medicine, Wakayama City, Japan.
FAU - Higuchi, Yukiharu
AU  - Higuchi Y
AD  - Department of Rehabilitation Medicine and Sports Medical Center, Wakayama Medical 
      University School of Medicine, Wakayama City, Japan.
FAU - Hosoe, Sayoko
AU  - Hosoe S
AD  - Department of Rehabilitation Medicine and Sports Medical Center, Wakayama Medical 
      University School of Medicine, Wakayama City, Japan.
FAU - Ito, Fumiaki
AU  - Ito F
AD  - Institute of Health Sciences, Sunstar Inc., Osaka, Japan.
FAU - Tajima, Fumihiro
AU  - Tajima F
AD  - Department of Rehabilitation Medicine and Sports Medical Center, Wakayama Medical 
      University School of Medicine, Wakayama City, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170511
PL  - England
TA  - Spinal Cord Ser Cases
JT  - Spinal cord series and cases
JID - 101680856
PMC - PMC5425958
OTO - NOTNLM
OT  - Fat metabolism
OT  - Nutrition
COIS- The authors declare no conflict of interest.
EDAT- 2017/05/16 06:00
MHDA- 2017/05/16 06:01
PMCR- 2018/05/11
CRDT- 2017/05/16 06:00
PHST- 2016/08/08 00:00 [received]
PHST- 2017/03/17 00:00 [revised]
PHST- 2017/03/27 00:00 [accepted]
PHST- 2017/05/16 06:00 [entrez]
PHST- 2017/05/16 06:00 [pubmed]
PHST- 2017/05/16 06:01 [medline]
PHST- 2018/05/11 00:00 [pmc-release]
AID - scsandc201715 [pii]
AID - 10.1038/scsandc.2017.15 [doi]
PST - epublish
SO  - Spinal Cord Ser Cases. 2017 May 11;3:17015. doi: 10.1038/scsandc.2017.15. 
      eCollection 2017.