PMID- 28503579
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2329-048X (Print)
IS  - 2329-048X (Electronic)
IS  - 2329-048X (Linking)
VI  - 1
IP  - 1
DP  - 2014 Jul-Sep
TI  - Anterior Commissure Involvement in Humanherpes Virus 6 Encephalitis.
PG  - 2329048X14544473
LID - 10.1177/2329048X14544473 [doi]
LID - 2329048X14544473
AB  - The anterior commissure is an evolutionarily conserved nerve bundle that connects 
      the right and left hemispheres, playing pivotal neurological roles in visual, 
      linguistic, and olfactory functions. The authors herein describe a 16-month-old 
      boy with high fever, lethargy, and recurrent seizures. Polymerase chain reaction 
      (PCR) examination detected human herpesvirus 6 (HHV-6) in both the cerebrospinal 
      fluid and the pharyngeal swabs, leading to the diagnosis of HHV-6 encephalitis. 
      Brain magnetic resonance imaging (MRI) 4 days after disease onset distinctly 
      revealed anterior commissure involvement on diffusion-weighted images and 
      apparent diffusion coefficient maps, suggesting that this lesion was cytotoxic 
      edema. After treatment with 30 mg/kg/d methylprednisolone for 3 days, the 
      anterior commissure involvement on MRI was completely diminished. This is the 
      first MRI report rarely showing anterior commissure involvement in encephalitis, 
      suggesting that this lesion might be caused by direct invasion of HHV-6 or 
      transient axonal swelling associated with inferior temporal lobe damage.
FAU - Fujii, Katsunori
AU  - Fujii K
AD  - Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, 
      Japan.
FAU - Ikehara, Hajime
AU  - Ikehara H
AD  - Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, 
      Japan.
FAU - Nagasawa, Koo
AU  - Nagasawa K
AD  - Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, 
      Japan.
FAU - Hishiki, Haruka
AU  - Hishiki H
AD  - Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, 
      Japan.
FAU - Uchikawa, Hideki
AU  - Uchikawa H
AD  - Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, 
      Japan.
FAU - Shimojo, Naoki
AU  - Shimojo N
AD  - Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20140826
PL  - United States
TA  - Child Neurol Open
JT  - Child neurology open
JID - 101691975
PMC - PMC5417093
OTO - NOTNLM
OT  - connecting fiber
OT  - cytotoxic edema
OT  - human herpesvirus 6
OT  - magnetic resonance imaging
COIS- Declaration of Conflicting Interests: The authors declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2014/08/26 00:00
MHDA- 2014/08/26 00:01
PMCR- 2014/08/26
CRDT- 2017/05/16 06:00
PHST- 2014/04/21 00:00 [received]
PHST- 2014/04/21 00:00 [revised]
PHST- 2014/06/01 00:00 [accepted]
PHST- 2017/05/16 06:00 [entrez]
PHST- 2014/08/26 00:00 [pubmed]
PHST- 2014/08/26 00:01 [medline]
PHST- 2014/08/26 00:00 [pmc-release]
AID - 10.1177_2329048X14544473 [pii]
AID - 10.1177/2329048X14544473 [doi]
PST - epublish
SO  - Child Neurol Open. 2014 Aug 26;1(1):2329048X14544473. doi: 
      10.1177/2329048X14544473. eCollection 2014 Jul-Sep.