PMID- 28504198
OWN - NLM
STAT- MEDLINE
DCOM- 20180328
LR  - 20180919
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 355
DP  - 2017 Jul 4
TI  - Rapamycin suppresses Abeta(25-35)- or LPS-induced neuronal inflammation via 
      modulation of NF-kappaB signaling.
PG  - 188-199
LID - S0306-4522(17)30321-4 [pii]
LID - 10.1016/j.neuroscience.2017.05.005 [doi]
AB  - Rapamycin (RAPA), an inhibitor of mammalian target of rapamycin (mTOR), exhibits 
      a high neuroprotective action against neurodegenerative diseases in mouse models. 
      Since neuroinflammation has been shown to be involved in Alzheimer's disease (AD) 
      development and progression, the aim of this study was to examine the 
      anti-inflammatory role of RAPA in AD in vivo and in vitro, and investigate the 
      underlying mechanisms. We found that amyloid-beta (Abeta) induced neuronal inflammation 
      and a remarkable increase in mTOR activity in in-vivo and in-vitro models of 
      inflammation, suggesting the critical role of mTOR signaling in neuronal 
      inflammation. In addition, administration of RAPA was found to down-regulate 
      mTOR, p-mTOR, Nuclear factor kappa B (NF-kappaB) p65, p-p65, TNF-alpha, IL-1beta and Bax 
      protein expression in Abeta(25-35)- or lipopolysaccharides (LPS)-treated mice and 
      cultured Neuro-2a (N2a) cells. Moreover, RAPA disrupted Abeta(25-35)-induced nuclear 
      translocation of mTOR and NF-kappaB. Our findings indicate that RAPA inhibits 
      Abeta(25-35)- or LPS-induced neuronal inflammation through suppressing mTOR 
      signaling and reducing nuclear import of NF-kappaB.
CI  - Copyright (c) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Liu, Ying-Chun
AU  - Liu YC
AD  - Department of Cell Biology and Genetics, School of Basic Medical Sciences, Fujian 
      Medical University, No. 1 Xueyuan Road, Shangjie Town, Minhou County, Fuzhou 
      City, Fujian Province 350108, China.
FAU - Gao, Xiao-Xiao
AU  - Gao XX
AD  - Department of Cell Biology and Genetics, School of Basic Medical Sciences, Fujian 
      Medical University, No. 1 Xueyuan Road, Shangjie Town, Minhou County, Fuzhou 
      City, Fujian Province 350108, China.
FAU - Chen, Ling
AU  - Chen L
AD  - Department of Cell Biology and Genetics, School of Basic Medical Sciences, Fujian 
      Medical University, No. 1 Xueyuan Road, Shangjie Town, Minhou County, Fuzhou 
      City, Fujian Province 350108, China.
FAU - You, Xiao-Qing
AU  - You XQ
AD  - Department of Cell Biology and Genetics, School of Basic Medical Sciences, Fujian 
      Medical University, No. 1 Xueyuan Road, Shangjie Town, Minhou County, Fuzhou 
      City, Fujian Province 350108, China. Electronic address: yxqtr@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170511
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (25-35))
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Amyloid beta-Peptides/*toxicity
MH  - Animals
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Brain/drug effects/pathology
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Inflammation/chemically induced/*drug therapy
MH  - Lipopolysaccharides/*toxicity
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - NF-kappa B/genetics/*metabolism
MH  - Neuroblastoma/pathology
MH  - Neuroglia/drug effects
MH  - Peptide Fragments/*toxicity
MH  - Signal Transduction/*drug effects
MH  - Sirolimus/*therapeutic use
MH  - Transfection
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Abeta(25-35)
OT  - NF-kappaB signaling
OT  - mTOR
OT  - neuronal inflammation
OT  - rapamycin
EDAT- 2017/05/16 06:00
MHDA- 2018/03/29 06:00
CRDT- 2017/05/16 06:00
PHST- 2016/08/30 00:00 [received]
PHST- 2017/04/25 00:00 [revised]
PHST- 2017/05/03 00:00 [accepted]
PHST- 2017/05/16 06:00 [pubmed]
PHST- 2018/03/29 06:00 [medline]
PHST- 2017/05/16 06:00 [entrez]
AID - S0306-4522(17)30321-4 [pii]
AID - 10.1016/j.neuroscience.2017.05.005 [doi]
PST - ppublish
SO  - Neuroscience. 2017 Jul 4;355:188-199. doi: 10.1016/j.neuroscience.2017.05.005. 
      Epub 2017 May 11.