PMID- 28505080
OWN - NLM
STAT- MEDLINE
DCOM- 20180302
LR  - 20181202
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 18
IP  - 5
DP  - 2017 May 13
TI  - First Insights into Human Fingertip Regeneration by Echo-Doppler Imaging and 
      Wound Microenvironment Assessment.
LID - 10.3390/ijms18051054 [doi]
LID - 1054
AB  - Fingertip response to trauma represents a fascinating example of tissue 
      regeneration. Regeneration derives from proliferative mesenchymal cells 
      (blastema) that subsequently differentiate into soft and skeletal tissues. 
      Clinically, conservative treatment of the amputated fingertip under occlusive 
      dressing can shift the response to tissue loss from a wound repair process 
      towards regeneration. When analyzing by Immunoassay the wound exudate from 
      occlusive dressings, the concentrations of brain-derived neurotrophic factor 
      (BDNF) and leukemia inhibitory factor (LIF) were higher in fingertip exudates 
      than in burn wounds (used as controls for wound repair versus regeneration). 
      Vascular endothelial growth factor A (VEGF-A) and platelet-derived growth factor 
      (PDGF) were highly expressed in both samples in comparable levels. In our study, 
      pro-inflammatory cytokines were relatively higher expressed in regenerative 
      fingertips than in the burn wound exudates while chemokines were present in lower 
      levels. Functional, vascular and mechanical properties of the regenerated 
      fingertips were analyzed three months after trauma and the data were compared to 
      the corresponding fingertip on the collateral uninjured side. While sensory 
      recovery and morphology (pulp thickness and texture) were similar to uninjured 
      sides, mechanical parameters (elasticity, vascularization) were increased in the 
      regenerated fingertips. Further studies should be done to clarify the importance 
      of inflammatory cells, immunity and growth factors in determining the outcome of 
      the regenerative process and its influence on the clinical outcome.
FAU - Jafari, Paris
AU  - Jafari P
AD  - Plastic and Hand Surgery Department, Lausanne University Hospital, 1011 Lausanne, 
      Switzerland. Paris.Jafari@chuv.ch.
FAU - Muller, Camillo
AU  - Muller C
AD  - Plastic and Hand Surgery Department, Lausanne University Hospital, 1011 Lausanne, 
      Switzerland. Camillo.Muller@chuv.ch.
FAU - Grognuz, Anthony
AU  - Grognuz A
AD  - Plastic and Hand Surgery Department, Lausanne University Hospital, 1011 Lausanne, 
      Switzerland. Anthony.Grognuz@chuv.ch.
FAU - Applegate, Lee Ann
AU  - Applegate LA
AD  - Plastic and Hand Surgery Department, Lausanne University Hospital, 1011 Lausanne, 
      Switzerland. Lee.Laurent-Applegate@chuv.ch.
FAU - Raffoul, Wassim
AU  - Raffoul W
AD  - Plastic and Hand Surgery Department, Lausanne University Hospital, 1011 Lausanne, 
      Switzerland. Wassim.Raffoul@chuv.ch.
FAU - di Summa, Pietro G
AU  - di Summa PG
AD  - Plastic and Hand Surgery Department, Lausanne University Hospital, 1011 Lausanne, 
      Switzerland. Pietro.Di-Summa@chuv.ch.
FAU - Durand, Sebastien
AU  - Durand S
AD  - Plastic and Hand Surgery Department, Lausanne University Hospital, 1011 Lausanne, 
      Switzerland. Sebastien.Durand@chuv.ch.
LA  - eng
PT  - Journal Article
DEP - 20170513
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (LIF protein, human)
RN  - 0 (Leukemia Inhibitory Factor)
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (platelet-derived growth factor A)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Burns/*genetics/physiopathology
MH  - Cell Differentiation/*genetics
MH  - Exudates and Transudates/immunology/metabolism/physiology
MH  - Finger Injuries/*genetics/physiopathology
MH  - Humans
MH  - Leukemia Inhibitory Factor/genetics
MH  - Male
MH  - Mesenchymal Stem Cells/metabolism/physiology
MH  - Middle Aged
MH  - Occlusive Dressings
MH  - Platelet-Derived Growth Factor/genetics
MH  - Regeneration/*genetics
MH  - Vascular Endothelial Growth Factor A/genetics
MH  - Wound Healing/genetics/physiology
PMC - PMC5454966
OTO - NOTNLM
OT  - Doppler imaging
OT  - angiogenesis
OT  - clinical assessment
OT  - fingertip regeneration
COIS- The authors declare no conflict of interest.
EDAT- 2017/05/16 06:00
MHDA- 2018/03/03 06:00
PMCR- 2017/05/01
CRDT- 2017/05/16 06:00
PHST- 2017/04/09 00:00 [received]
PHST- 2017/05/03 00:00 [revised]
PHST- 2017/05/06 00:00 [accepted]
PHST- 2017/05/16 06:00 [entrez]
PHST- 2017/05/16 06:00 [pubmed]
PHST- 2018/03/03 06:00 [medline]
PHST- 2017/05/01 00:00 [pmc-release]
AID - ijms18051054 [pii]
AID - ijms-18-01054 [pii]
AID - 10.3390/ijms18051054 [doi]
PST - epublish
SO  - Int J Mol Sci. 2017 May 13;18(5):1054. doi: 10.3390/ijms18051054.