PMID- 28506809
OWN - NLM
STAT- MEDLINE
DCOM- 20180430
LR  - 20180430
IS  - 1879-0828 (Electronic)
IS  - 0953-6205 (Linking)
VI  - 42
DP  - 2017 Jul
TI  - Women with atrial fibrillation and type 2 diabetes have a higher incidence of 
      hospitalization and undergo ablation or pacemaker implantation less frequently 
      than men.
PG  - 67-73
LID - S0953-6205(17)30184-X [pii]
LID - 10.1016/j.ejim.2017.05.008 [doi]
AB  - BACKGROUND: We reviewed trends from 2004 to 2013 in the incidence and outcomes 
      for atrial fibrillation (AF) in Spanish patients with type 2 diabetes mellitus 
      (T2DM) comparing women and men. METHODS: We used national hospital discharge data 
      including all T2DM patients discharged from the hospital after AF. Patients with 
      AF in the primary diagnosis field were selected. Discharges were grouped by sex. 
      Incidence was calculated overall and stratified by sex. We analyzed diagnostic 
      and therapeutic procedures, patient comorbidities, CHA2DS2-VASc score, length of 
      hospital stay, readmission rates and in-hospital mortality (IHM). RESULTS: We 
      identified a total of 214,457 admissions for AF. Patients with T2DM accounted for 
      21.1% (19,505 men and 25,954 women). Women with T2DM had a significantly higher 
      incidence of AF compared to men over the study period (IRR 1.33;95%CI 1.31-1.35). 
      Women were significantly older (77.24+/-8.69years) than men (72.62+/-10.28years), had 
      higher prevalences of obesity and hypertension, and higher CHA2DS2-VASc score. 
      Women less frequently underwent ablation (3.21% vs. 1.54%; p<0.001) and received 
      an implanted pacemaker (14.3% vs. 8.16%; p<0.001) than men. Crude IHM was 2.81% 
      for women and 2.48% for men (p=0.030). Sex was not associated with a higher IHM 
      after multivariable adjustment. CONCLUSIONS: Our study demonstrates an increase 
      in hospitalization for AF in diabetic women. Women were older, had a higher 
      comorbidity index and had CHAD2DS2-VASc score than men. Women with AF and T2DM 
      undergo ablation or pacemaker implantation less frequently than their male 
      counterparts. After multivariable adjustment sex did not predict mortality during 
      admissions for AF.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Mendez-Bailon, Manuel
AU  - Mendez-Bailon M
AD  - Medicine Department, Hospital Clinico San Carlos, Madrid, Comunidad de Madrid, 
      Spain. Electronic address: manuel.mendez@salud.madrid.org.
FAU - Munoz-Rivas, Nuria
AU  - Munoz-Rivas N
AD  - Medicine Department, Hospital Universitario Infanta Leonor, Madrid, Spain.
FAU - Jimenez-Garcia, Rodrigo
AU  - Jimenez-Garcia R
AD  - Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences 
      Faculty, Rey Juan Carlos University, Alcorcon, Comunidad de Madrid, Spain.
FAU - Hernandez-Barrera, Valentin
AU  - Hernandez-Barrera V
AD  - Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences 
      Faculty, Rey Juan Carlos University, Alcorcon, Comunidad de Madrid, Spain.
FAU - de Miguel-Yanes, Jose M feminine
AU  - de Miguel-Yanes JM
AD  - Medicine Department, Hospital Gregorio Maranon, Comunidad de Madrid, Spain.
FAU - Villalba, Noel Lorenzo
AU  - Villalba NL
AD  - Medicine Department, Centre Hospitalaire Saint Cyr, Toulouse, France.
FAU - de Miguel Diez, Javier
AU  - de Miguel Diez J
AD  - Pneumology Department, Hospital Gregorio Maranon, Madrid, Spain.
FAU - Lopez-de-Andres, Ana
AU  - Lopez-de-Andres A
AD  - Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences 
      Faculty, Rey Juan Carlos University, Alcorcon, Comunidad de Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170512
PL  - Netherlands
TA  - Eur J Intern Med
JT  - European journal of internal medicine
JID - 9003220
SB  - IM
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrial Fibrillation/*mortality/therapy
MH  - Catheter Ablation
MH  - Databases, Factual
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Hospital Mortality/*trends
MH  - *Hospitalization
MH  - Humans
MH  - Hypertension/complications
MH  - Incidence
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Obesity/complications
MH  - Pacemaker, Artificial
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Sex Distribution
MH  - Spain/epidemiology
OTO - NOTNLM
OT  - Ablation
OT  - Atrial fibrillation
OT  - Gender differences
OT  - Implanted pacemaker
OT  - Mortality
OT  - Type 2 diabetes mellitus (T2DM)
EDAT- 2017/05/17 06:00
MHDA- 2018/05/01 06:00
CRDT- 2017/05/17 06:00
PHST- 2016/10/21 00:00 [received]
PHST- 2017/02/20 00:00 [revised]
PHST- 2017/05/08 00:00 [accepted]
PHST- 2017/05/17 06:00 [pubmed]
PHST- 2018/05/01 06:00 [medline]
PHST- 2017/05/17 06:00 [entrez]
AID - S0953-6205(17)30184-X [pii]
AID - 10.1016/j.ejim.2017.05.008 [doi]
PST - ppublish
SO  - Eur J Intern Med. 2017 Jul;42:67-73. doi: 10.1016/j.ejim.2017.05.008. Epub 2017 
      May 12.