PMID- 28507483
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1611-2156 (Print)
IS  - 1611-2156 (Electronic)
IS  - 1611-2156 (Linking)
VI  - 16
DP  - 2017
TI  - Effects of hesperidin on formaldehyde-induced toxicity in pregnant rats.
PG  - 400-413
LID - 10.17179/excli2017-142 [doi]
AB  - This experimental study aimed to investigate the protective effect of a 
      bioflavonoid, hesperidin (HP), on formaldehyde (FA)-related pathophysiological 
      and behavioral outcomes in pregnant rats and developmental aspects in their 
      offspring. Female Wistar rats were subjected to perigestational exposure to FA (2 
      mg/kg/day per os) with a concomitant treatment with HP (50 mg/kg/day per os). 
      Pregnant rats were weighed throughout gestation and tested in two behavioral 
      paradigms (elevated plus-maze and open field) at gestational days (GD) 1, 10 and 
      19 to evaluate the anxiety-like behavior and locomotive alterations. Another 
      subset of rats was decapitated at GD19 to determine the hematological profile 
      along with cortisol, 17beta-estradiol, and progesterone plasma levels. Reproductive 
      and fetal measures and observations were also performed to check for 
      developmental deformities. Significant body weight loss, hemato-immune decline, 
      hormonal changes, anxiety and lethargy signs, locomotor disabilities, 
      reproductive failure and fetal weight decrease were observed in FA-exposed rats. 
      Treatment with HP alleviated the reproductive and fetal weight defects. Its 
      behavioral benefits were only seen at GD1 and 10. This flavanone ameliorated some 
      hematological parameters, decreased cortisol levels and increased 17beta-estradiol 
      rates. A potential preventive impact of HP was found against FA toxicity in 
      pregnant rats.
FAU - Merzoug, Sameha
AU  - Merzoug S
AD  - Department of Biology, Faculty of Natural and Life Sciences, University of Chadli 
      Bendjedid - El-Tarf, BP 73, 36000, El-Tarf, Algeria.
FAU - Toumi, Mohamed Lamine
AU  - Toumi ML
AD  - Department of Biology, Faculty of Natural and Life Sciences, University of Chadli 
      Bendjedid - El-Tarf, BP 73, 36000, El-Tarf, Algeria.
LA  - eng
PT  - Journal Article
DEP - 20170330
PL  - Germany
TA  - EXCLI J
JT  - EXCLI journal
JID - 101299402
PMC - PMC5427472
OTO - NOTNLM
OT  - behavior
OT  - fetal development
OT  - formaldehyde
OT  - gestation
OT  - hesperidin
OT  - pathophysiology
EDAT- 2017/05/17 06:00
MHDA- 2017/05/17 06:01
PMCR- 2017/03/30
CRDT- 2017/05/17 06:00
PHST- 2017/01/14 00:00 [received]
PHST- 2017/03/14 00:00 [accepted]
PHST- 2017/05/17 06:00 [entrez]
PHST- 2017/05/17 06:00 [pubmed]
PHST- 2017/05/17 06:01 [medline]
PHST- 2017/03/30 00:00 [pmc-release]
AID - 2017-142 [pii]
AID - Doc400 [pii]
AID - 10.17179/excli2017-142 [doi]
PST - epublish
SO  - EXCLI J. 2017 Mar 30;16:400-413. doi: 10.17179/excli2017-142. eCollection 2017.