PMID- 28507530 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 1664-2295 (Print) IS - 1664-2295 (Electronic) IS - 1664-2295 (Linking) VI - 8 DP - 2017 TI - Brain-Derived Neurotrophic Factor Val66Met Gene Polymorphism Impacts on Migraine Susceptibility: A Meta-analysis of Case-Control Studies. PG - 159 LID - 10.3389/fneur.2017.00159 [doi] LID - 159 AB - Inconclusive results have been reported in studies investigating the association between the brain-derived neurotrophic factor (BDNF) rs6265 polymorphism and migraine. In the present study, we conducted a systematic review and meta-analysis on the published data in order to quantitatively estimate the relationship between rs6265 and migraine susceptibility. A comprehensive search was performed through PubMed, Web of Knowledge, and Cochrane databases up to October 2016. The pooled odds ratio (OR) with the corresponding 95% confidence interval (CI) was calculated to estimate the strength of the association with rs6265 under an additive, dominant, or recessive model of inheritance. A total of five studies including 1,442 cases and 1,880 controls were identified for the meta-analysis. The pooled data showed an increased risk of migraine for the allelic (OR: 1.17, 95% CI: 1.03-1.34, p = 0.014) or the dominant model of rs6265 (OR: 1.22, 95% CI: 1.05-1.41, p = 0.011). Statistical significance of rs6265 was lost when one single study was excluded from the analysis (dominant OR: 1.17, 95% CI: 1.00-1.38, p = 0.054; allelic OR: 1.14, 95% CI: 0.99-1.31, p = 0.067), suggesting lack of robustness of pooled estimates. When stratified by migraine type, a similar trend of association was detected with both MA and MO, but a statistically significant association of rs6265 was reached only with the MA subtype in the dominant model (OR: 1.22, 95% CI: 1.00-1.47, p = 0.047). The present meta-analysis supports that BDNF rs6265 may act as a genetic susceptibility factor for migraine. Nevertheless, large-scale studies are required to confirm our findings and to assess potential modifiers of the relationship between rs6265 and migraine. FAU - Terrazzino, Salvatore AU - Terrazzino S AD - Department of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF), University of Piemonte Orientale "A. Avogadro", Novara, Italy. FAU - Cargnin, Sarah AU - Cargnin S AD - Department of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF), University of Piemonte Orientale "A. Avogadro", Novara, Italy. FAU - Viana, Michele AU - Viana M AD - Headache Science Center, C. Mondino National Neurological Institute, Pavia, Italy. AD - Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. FAU - Sances, Grazia AU - Sances G AD - Headache Science Center, C. Mondino National Neurological Institute, Pavia, Italy. FAU - Tassorelli, Cristina AU - Tassorelli C AD - Headache Science Center, C. Mondino National Neurological Institute, Pavia, Italy. AD - Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. LA - eng PT - Journal Article PT - Review DEP - 20170501 PL - Switzerland TA - Front Neurol JT - Frontiers in neurology JID - 101546899 PMC - PMC5410590 OTO - NOTNLM OT - brain-derived neurotrophic factor OT - meta-analysis OT - migraine OT - single-nucleotide polymorphism OT - susceptibility EDAT- 2017/05/17 06:00 MHDA- 2017/05/17 06:01 PMCR- 2017/05/01 CRDT- 2017/05/17 06:00 PHST- 2017/02/19 00:00 [received] PHST- 2017/04/04 00:00 [accepted] PHST- 2017/05/17 06:00 [entrez] PHST- 2017/05/17 06:00 [pubmed] PHST- 2017/05/17 06:01 [medline] PHST- 2017/05/01 00:00 [pmc-release] AID - 10.3389/fneur.2017.00159 [doi] PST - epublish SO - Front Neurol. 2017 May 1;8:159. doi: 10.3389/fneur.2017.00159. eCollection 2017.