PMID- 28508156
OWN - NLM
STAT- MEDLINE
DCOM- 20180404
LR  - 20181113
IS  - 1432-1076 (Electronic)
IS  - 0340-6199 (Linking)
VI  - 176
IP  - 7
DP  - 2017 Jul
TI  - Pulse wave velocity measurement as a marker of arterial stiffness in pediatric 
      inflammatory bowel disease: a pilot study.
PG  - 983-987
LID - 10.1007/s00431-017-2927-7 [doi]
AB  - In adults with inflammatory bowel disease (IBD), the incidence of cardiovascular 
      events is increased, leading to long-term morbidity. Arterial stiffness (AS) 
      measured by pulse wave velocity (PWV) is a validated early precursor of 
      cardiovascular disease (CVD), and measurement of PWV was shown to be a feasible 
      test in children. The aim of this study was to assess AS in children with IBD. In 
      this prospective study, we determined PWV between the carotid and femoral artery 
      (PWV(cf)) in 25 children and adolescents with IBD (11 females, median age 
      14.1 years, median disease duration 2.8 years). The majority (68%) of the 
      subjects were in clinical remission, and 48% received anti-tumor necrosis factor 
      alpha (TNFalpha) treatment. AS was not increased in this cohort of children and 
      adolescents with IBD, who did not have signs of cardiovascular disease, such as 
      arterial hypertension. CONCLUSION: PWV seems to be normal in children with IBD in 
      remission or with mild disease activity. Larger studies should assess its 
      potential role as a valid and non-invasive follow-up marker in children with IBD, 
      to avoid cardiovascular complications. What is Known : * Inflammatory bowel 
      disease (IBD) is a risk factor of cardiovascular disease (CVD). * Pulse wave 
      velocity (PWV) measurement is the current gold standard to assess arterial 
      stiffness (AS), which is an early predictor of CVD. What is New: * This is the 
      first study using PWV measurements to determine AS in children with IBD. * In 
      children with IBD in remission or only mild disease activity AS is not increased.
FAU - Lurz, Eberhard
AU  - Lurz E
AD  - Division of Pediatric Gastroenterology, Hepatology and Nutrition, University 
      Children's Hospital, Inselspital, University of Bern, Bern, Switzerland.
AD  - Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Hospital for 
      Sick Children, Toronto, ON, Canada.
FAU - Aeschbacher, Eliane
AU  - Aeschbacher E
AD  - Division of Pediatric Gastroenterology, Hepatology and Nutrition, University 
      Children's Hospital, Inselspital, University of Bern, Bern, Switzerland.
AD  - Division of Pediatric Nephrology, University Children's Hospital, Inselspital, 
      University of Bern, Bern, Switzerland.
FAU - Carman, Nicholas
AU  - Carman N
AD  - Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Hospital for 
      Sick Children, Toronto, ON, Canada.
FAU - Schibli, Susanne
AU  - Schibli S
AD  - Division of Pediatric Gastroenterology, Hepatology and Nutrition, University 
      Children's Hospital, Inselspital, University of Bern, Bern, Switzerland.
FAU - Sokollik, Christiane
AU  - Sokollik C
AD  - Division of Pediatric Gastroenterology, Hepatology and Nutrition, University 
      Children's Hospital, Inselspital, University of Bern, Bern, Switzerland.
FAU - Simonetti, Giacomo D
AU  - Simonetti GD
AD  - Division of Pediatric Nephrology, University Children's Hospital, Inselspital, 
      University of Bern, Bern, Switzerland. giacomo.simonetti@eoc.ch.
AD  - Pediatric Department of Southern Switzerland, 6500, Bellinzona, Switzerland. 
      giacomo.simonetti@eoc.ch.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20170515
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
SB  - IM
MH  - Adolescent
MH  - Cardiovascular Diseases/diagnosis/etiology
MH  - Carotid Arteries/*physiopathology
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Femoral Artery/*physiopathology
MH  - Humans
MH  - Inflammatory Bowel Diseases/complications/*physiopathology
MH  - Linear Models
MH  - Male
MH  - Pilot Projects
MH  - Prospective Studies
MH  - *Pulse Wave Analysis
MH  - *Vascular Stiffness
OTO - NOTNLM
OT  - Arterial stiffness
OT  - Cardiovascular disease
OT  - IBD
OT  - Inflammation
OT  - PWV
OT  - Pulse wave velocity
EDAT- 2017/05/17 06:00
MHDA- 2018/04/05 06:00
CRDT- 2017/05/17 06:00
PHST- 2016/12/09 00:00 [received]
PHST- 2017/05/08 00:00 [accepted]
PHST- 2017/05/03 00:00 [revised]
PHST- 2017/05/17 06:00 [pubmed]
PHST- 2018/04/05 06:00 [medline]
PHST- 2017/05/17 06:00 [entrez]
AID - 10.1007/s00431-017-2927-7 [pii]
AID - 10.1007/s00431-017-2927-7 [doi]
PST - ppublish
SO  - Eur J Pediatr. 2017 Jul;176(7):983-987. doi: 10.1007/s00431-017-2927-7. Epub 2017 
      May 15.