PMID- 28508312
OWN - NLM
STAT- MEDLINE
DCOM- 20170922
LR  - 20170922
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 976
DP  - 2017
TI  - TRPC Channels and Programmed Cell Death.
PG  - 47-60
LID - 10.1007/978-94-024-1088-4_5 [doi]
AB  - Neurotrophins, including nerve growth factor (NGF) and brain-derived neurotrophic 
      factor (BDNF), bind to their high-affinity receptors to promote neuronal survival 
      during brain development. One of the key downstream pathways is the phospholipase 
      C (PLC) pathway, which not only plays a central role in calcium release from 
      internal store but also in activation of TRPC channels coupled with neurotrophin 
      receptors. TRPC channels are required for the neurotrophin-mediated neuronal 
      protective effects. In addition, activation of TRPC channels is able to protect 
      neurons in the absence of neurotrophin. In some circumstances, TRPC channels 
      coupled with metabotropic glutamate receptor may mediate the excitotoxicity by 
      calcium overload. One of the key questions in the field is the channel gating 
      mechanisms; understanding of which would help design compounds to modulate the 
      channel properties. The development and identification of TRPC channel agonists 
      or blockers are promising and may unveil new therapeutic drugs for the treatment 
      of neurodegenerative diseases and epilepsy.
FAU - Zhou, Jian
AU  - Zhou J
AD  - Laboratory of Neural Signal Transduction, Institute of Neuroscience, Shanghai 
      Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang 
      Road, Shanghai, 200031, China.
FAU - Jia, Yichang
AU  - Jia Y
AD  - School of Medicine, Tsinghua University, Medical Science Building, Room D204, 
      Beijing, 100084, China. yichangjia@tsinghua.edu.cn.
AD  - Peking-Tsinghua Joint Center for Life Sciences, Beijing, 100084, China. 
      yichangjia@tsinghua.edu.cn.
AD  - IDG/McGovern Institute for Brain Research at Tsinghua, Beijing, 100084, China. 
      yichangjia@tsinghua.edu.cn.
LA  - eng
GR  - NS079476/NH/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (TRPC Cation Channels)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Calcium/*metabolism
MH  - Cell Death/*physiology
MH  - Humans
MH  - Nerve Growth Factor/*metabolism
MH  - Neurons/*metabolism
MH  - Signal Transduction/physiology
MH  - TRPC Cation Channels/*metabolism
OTO - NOTNLM
OT  - Neurotrophins
OT  - Programmed cell death
OT  - TRPC channels
EDAT- 2017/05/17 06:00
MHDA- 2017/09/25 06:00
CRDT- 2017/05/17 06:00
PHST- 2017/05/17 06:00 [entrez]
PHST- 2017/05/17 06:00 [pubmed]
PHST- 2017/09/25 06:00 [medline]
AID - 10.1007/978-94-024-1088-4_5 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2017;976:47-60. doi: 10.1007/978-94-024-1088-4_5.