PMID- 28509461 OWN - NLM STAT- MEDLINE DCOM- 20180208 LR - 20180208 IS - 1561-9125 (Print) IS - 1561-9125 (Linking) VI - 28 IP - 4 DP - 2015 TI - [Age and gender aspects of the status of lipid profile and stress-realizing systems of the human body in the aging process]. PG - 718-724 AB - In the course of inspection 1136 persons of different age and sex data on dynamics of the main components of lipid profile, the concentration of brain-derived neurotrophic factor (BDNF) in blood plasma and indicators of levels of free cortisol, melatonin sulfate, metanephrine and normetanephrine in urine daily were obtained. Clear age and gender differences related both to the content of atherogenic fractions of lipids in the blood, and types of dyslipidemia were revealed. Fundamental differences in the age dynamics of indicators of stress-realizing systems in men and women and the correlation of these indicators with the level of low density lipoproteins and atherogenic coefficient were identified. The data obtained may indicate different mechanisms of development of atherosclerosis and its associated pathological aging in people of different sex and age, which enables the practical use of research results for the earliest diagnosis and prognosis of a number of associated with age and pathological conditions. FAU - Myakotnykh, V S AU - Myakotnykh VS AD - Ural State Medical University, Ekaterinburg, 620036, Russian Federation; vmaykotnykh@yandex.ru. FAU - Emelyanov, V V AU - Emelyanov VV AD - B. N. Yeltsin Ural Federal University, Ekaterinburg, 620002, Russian Federation. FAU - Gavrilov, V I AU - Gavrilov VI AD - Ural State Medical University, Ekaterinburg, 620036, Russian Federation; vmaykotnykh@yandex.ru. FAU - Ermakova, E Y AU - Ermakova EY AD - Sverdlovsk regional clinical psychoneurogical hospital for veterans of wars, Ekaterinburg, 620036, Russian Federation. FAU - Soloviev, R V AU - Soloviev RV AD - Sverdlovsk regional clinical psychoneurogical hospital for veterans of wars, Ekaterinburg, 620036, Russian Federation. FAU - Borovkova, T A AU - Borovkova TA AD - Ural State Medical University, Ekaterinburg, 620036, Russian Federation; vmaykotnykh@yandex.ru. FAU - Kutyreva, Y E AU - Kutyreva YE AD - Sverdlovsk regional clinical psychoneurogical hospital for veterans of wars, Ekaterinburg, 620036, Russian Federation. FAU - Berezina, D A AU - Berezina DA AD - Ural State Medical University, Ekaterinburg, 620036, Russian Federation; vmaykotnykh@yandex.ru. FAU - Torgashov, M N AU - Torgashov MN AD - Ural State Medical University, Ekaterinburg, 620036, Russian Federation; vmaykotnykh@yandex.ru. FAU - Myakotnykh, K V AU - Myakotnykh KV AD - Ural State Medical University, Ekaterinburg, 620036, Russian Federation; vmaykotnykh@yandex.ru. LA - rus PT - Journal Article PL - Russia (Federation) TA - Adv Gerontol JT - Advances in gerontology = Uspekhi gerontologii JID - 100971443 RN - 0 (Lipoproteins, HDL) RN - 0 (Lipoproteins, LDL) RN - 0 (Triglycerides) SB - IM MH - Adult MH - Age Factors MH - Aged MH - Aging/metabolism MH - *Atherosclerosis/blood/epidemiology MH - *Dyslipidemias/blood/diagnosis/epidemiology MH - Female MH - Humans MH - Lipid Metabolism/physiology MH - Lipoproteins, HDL/*blood MH - Lipoproteins, LDL/*blood MH - Male MH - Middle Aged MH - Risk Factors MH - Russia/epidemiology MH - Sex Factors MH - Statistics as Topic MH - Stress, Physiological/physiology MH - Triglycerides/*blood OTO - NOTNLM OT - aging OT - atherosclerosis OT - lipids OT - stress-realizing system EDAT- 2015/01/01 00:00 MHDA- 2015/01/01 00:01 CRDT- 2017/05/17 06:00 PHST- 2017/05/17 06:00 [entrez] PHST- 2015/01/01 00:00 [pubmed] PHST- 2015/01/01 00:01 [medline] PST - ppublish SO - Adv Gerontol. 2015;28(4):718-724.