PMID- 28509588
OWN - NLM
STAT- MEDLINE
DCOM- 20171212
LR  - 20210709
IS  - 1521-0464 (Electronic)
IS  - 1071-7544 (Print)
IS  - 1071-7544 (Linking)
VI  - 24
IP  - 1
DP  - 2017 Nov
TI  - PEG-lipid-PLGA hybrid nanoparticles loaded with berberine-phospholipid complex to 
      facilitate the oral delivery efficiency.
PG  - 825-833
LID - 10.1080/10717544.2017.1321062 [doi]
AB  - The natural product berberine (BBR), present in various plants, arouses great 
      interests because of its numerous pharmacological effects. However, the further 
      development and application of BBR had been hampered by its poor oral 
      bioavailability. In this work, we report on polymer-lipid hybrid nanoparticles 
      (PEG-lipid-PLGA NPs) loaded with BBR phospholipid complex using a solvent 
      evaporation method for enhancing the oral BBR efficiency. The advantage of this 
      new drug delivery system is that the BBR-soybean phosphatidylcholine complex 
      (BBR-SPC) could be used to enhance the liposolubility of BBR and improve the 
      affinity with the biodegradable polymer to increase the drug-loading capacity and 
      controlled/sustained release. The entrapment efficiency of the PEG-lipid-PLGA 
      NPs/BBR-SPC was observed to approach approximately 89% which is more than 2.4 
      times compared with that of the PEG-lipid-PLGA NPs/BBR. To the best of our 
      knowledge, this is the first report on using polymer material for effective 
      encapsulation of BBR to improve its oral bioavailability. The prepared BBR 
      delivery systems demonstrated a uniform spherical shape, a well-dispersed 
      core-shell structure and a small particle size (149.6 +/- 5.1 nm). The 
      crystallographic and thermal analysis has indicated that the BBR dispersed in the 
      PEG-lipid-PLGA NPs matrix is in an amorphous form. More importantly, the 
      enhancement in the oral relative bioavailability of the PEG-lipid-PLGA 
      NPs/BBR-SPC was  approximately 343% compared with that of BBR. These positive results 
      demonstrated that PEG-lipid-PLGA NPs/BBR-SPC may have the potential for 
      facilitating the oral drug delivery of BBR.
FAU - Yu, Fei
AU  - Yu F
AD  - a Fujian Key Laboratory of Organ and Tissue Regeneration, Organ Transplantation 
      Institute, Medical College, Xiamen University, Xiamen, China.
FAU - Ao, Mingtao
AU  - Ao M
AD  - b School of Pharmaceutical Sciences, Xiamen University , Xiamen , China.
FAU - Zheng, Xiao
AU  - Zheng X
AD  - c Cancer Research Center, Medical College, Xiamen University , Xiamen , China.
FAU - Li, Nini
AU  - Li N
AD  - d School of Basic Medical Sciences, Fujian Medical University , Fuzhou , China.
FAU - Xia, Junjie
AU  - Xia J
AD  - a Fujian Key Laboratory of Organ and Tissue Regeneration, Organ Transplantation 
      Institute, Medical College, Xiamen University, Xiamen, China.
FAU - Li, Yang
AU  - Li Y
AD  - e Department of Biomaterials , College of Materials , and.
FAU - Li, Donghui
AU  - Li D
AD  - c Cancer Research Center, Medical College, Xiamen University , Xiamen , China.
FAU - Hou, Zhenqing
AU  - Hou Z
AD  - e Department of Biomaterials , College of Materials , and.
FAU - Qi, Zhongquan
AU  - Qi Z
AD  - a Fujian Key Laboratory of Organ and Tissue Regeneration, Organ Transplantation 
      Institute, Medical College, Xiamen University, Xiamen, China.
FAU - Chen, Xiao Dong
AU  - Chen XD
AD  - f Department of Chemical and Biochemical Engineering , College of Chemistry and 
      Chemical Engineering, Xiamen University , Xiamen , China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Drug Deliv
JT  - Drug delivery
JID - 9417471
RN  - 0 (Phospholipids)
RN  - 0I8Y3P32UF (Berberine)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Berberine/*chemistry
MH  - Lactic Acid
MH  - Nanoparticles
MH  - Particle Size
MH  - Phospholipids/*chemistry
MH  - Polyglycolic Acid
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
PMC - PMC8241132
OTO - NOTNLM
OT  - Nanoparticles
OT  - PLGA
OT  - berberine
OT  - oral
EDAT- 2017/05/17 06:00
MHDA- 2017/12/13 06:00
PMCR- 2017/05/16
CRDT- 2017/05/17 06:00
PHST- 2017/05/17 06:00 [entrez]
PHST- 2017/05/17 06:00 [pubmed]
PHST- 2017/12/13 06:00 [medline]
PHST- 2017/05/16 00:00 [pmc-release]
AID - 1321062 [pii]
AID - 10.1080/10717544.2017.1321062 [doi]
PST - ppublish
SO  - Drug Deliv. 2017 Nov;24(1):825-833. doi: 10.1080/10717544.2017.1321062.