PMID- 28511848
OWN - NLM
STAT- MEDLINE
DCOM- 20180328
LR  - 20220409
IS  - 1878-1861 (Electronic)
IS  - 1878-1861 (Linking)
VI  - 20
IP  - 10
DP  - 2017 Oct
TI  - Intense resistance exercise increases peripheral brain-derived neurotrophic 
      factor.
PG  - 899-903
LID - S1440-2440(17)30347-X [pii]
LID - 10.1016/j.jsams.2017.03.015 [doi]
AB  - OBJECTIVES: Brain-derived neurotrophic factor (BDNF) has been shown to increase 
      in an intensity dependent manner in response to aerobic exercise. However, 
      previous research investigating the use of resistance exercise to increase BDNF 
      levels has been less conclusive, likely due to the low intensity nature of 
      traditional resistance exercise programs. This study examined the influence of 
      acute resistance exercise to-fatigue on serum BDNF levels and blood lactate. 
      DESIGN: Acute crossover study. METHODS: Eleven untrained to intermediately 
      trained males (age: 25.0+/-1.3 year) and five untrained females (age: 23.2+/-1.1 
      year) were recruited to undertake two bouts of resistance exercise. Strength 
      (five sets of five repetitions, 180s recovery) and hypertrophy (three sets of ten 
      repetitions, 60s recovery) based resistance exercise was implemented to-fatigue 
      to examine the effect on serum BDNF and blood lactate levels immediately post-, 
      and 30min post-exercise. RESULTS: An interaction (p<0.01; ES=0.52) was observed 
      between conditions immediately post-exercise, with hypertrophy resulting in 
      significantly greater BDNF levels when compared with strength exercise. Changes 
      in lactate and BDNF from baseline to post- exercise were positively correlated 
      following hypertrophy exercise (r=0.70; p<0.01), but not correlated following 
      strength exercise (r=0.18; p=0.56). CONCLUSIONS: The use of a to-fatigue 
      hypertrophy based resistance exercise protocol provides the necessary stimulus to 
      increase peripheral serum BDNF. Mechanistically, the presence of lactate does not 
      appear to drive the BDNF response during resistance exercise.
CI  - Copyright (c) 2017 Sports Medicine Australia. Published by Elsevier Ltd. All rights 
      reserved.
FAU - Marston, Kieran J
AU  - Marston KJ
AD  - School of Psychology and Exercise Science, Murdoch University, Australia. 
      Electronic address: K.Marston@murdoch.edu.au.
FAU - Newton, Michael J
AU  - Newton MJ
AD  - School of Psychology and Exercise Science, Murdoch University, Australia.
FAU - Brown, Belinda M
AU  - Brown BM
AD  - School of Psychology and Exercise Science, Murdoch University, Australia; Centre 
      of Excellence for Alzheimer's Disease Research & Care, School of Medical and 
      Health Sciences, Edith Cowan University, Australia; Sir James McCusker 
      Alzheimer's Disease Research Unit (Hollywood Private Hospital), Australia.
FAU - Rainey-Smith, Stephanie R
AU  - Rainey-Smith SR
AD  - Centre of Excellence for Alzheimer's Disease Research & Care, School of Medical 
      and Health Sciences, Edith Cowan University, Australia; Sir James McCusker 
      Alzheimer's Disease Research Unit (Hollywood Private Hospital), Australia.
FAU - Bird, Sabine
AU  - Bird S
AD  - Centre of Excellence for Alzheimer's Disease Research & Care, School of Medical 
      and Health Sciences, Edith Cowan University, Australia; Sir James McCusker 
      Alzheimer's Disease Research Unit (Hollywood Private Hospital), Australia; School 
      of Psychiatry and Clinical Neurosciences, University of Western Australia, 
      Australia.
FAU - Martins, Ralph N
AU  - Martins RN
AD  - Centre of Excellence for Alzheimer's Disease Research & Care, School of Medical 
      and Health Sciences, Edith Cowan University, Australia; Sir James McCusker 
      Alzheimer's Disease Research Unit (Hollywood Private Hospital), Australia; School 
      of Psychiatry and Clinical Neurosciences, University of Western Australia, 
      Australia.
FAU - Peiffer, Jeremiah J
AU  - Peiffer JJ
AD  - School of Psychology and Exercise Science, Murdoch University, Australia.
LA  - eng
PT  - Journal Article
DEP - 20170321
PL  - Australia
TA  - J Sci Med Sport
JT  - Journal of science and medicine in sport
JID - 9812598
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cross-Over Studies
MH  - Female
MH  - Humans
MH  - Lactic Acid/blood
MH  - Male
MH  - Resistance Training/*methods
MH  - Young Adult
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Lactate
OT  - Muscular fatigue
OT  - Neurotrophin
OT  - Strength training
EDAT- 2017/05/18 06:00
MHDA- 2018/03/29 06:00
CRDT- 2017/05/18 06:00
PHST- 2016/11/03 00:00 [received]
PHST- 2017/01/20 00:00 [revised]
PHST- 2017/03/13 00:00 [accepted]
PHST- 2017/05/18 06:00 [pubmed]
PHST- 2018/03/29 06:00 [medline]
PHST- 2017/05/18 06:00 [entrez]
AID - S1440-2440(17)30347-X [pii]
AID - 10.1016/j.jsams.2017.03.015 [doi]
PST - ppublish
SO  - J Sci Med Sport. 2017 Oct;20(10):899-903. doi: 10.1016/j.jsams.2017.03.015. Epub 
      2017 Mar 21.